SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ws6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 PHE A  46
ALA A  73
PHE A  59
PHE A 129
 None
 1.24A 1lqtA-1ws6A:
3.3		 1lqtA-1ws6A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 PHE A  46
ALA A  73
PHE A  59
PHE A 129
 None
 1.23A 1lquA-1ws6A:
3.3		 1lquA-1ws6A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A  65
ALA A  89
GLU A  84
PHE A  63
ALA A 131
 None
 1.19A 3nvkF-1ws6A:
undetectable
3nvkJ-1ws6A:
12.6		 3nvkF-1ws6A:
20.42
3nvkJ-1ws6A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  25
ALA A  23
LEU A 102
LEU A  19
 None
 1.15A 3p5nA-1ws6A:
undetectable		 3p5nA-1ws6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  28
GLY A  25
ALA A  23
LEU A 102
LEU A  19
 None
 1.15A 3p5nB-1ws6A:
undetectable		 3p5nB-1ws6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A  65
SER A  66
ASP A  86
VAL A 111
LEU A 141
 None
 1.10A 3v8vA-1ws6A:
13.0		 3v8vA-1ws6A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A  65
SER A  66
ASP A  86
VAL A 111
PRO A 133
 None
 0.91A 3v8vA-1ws6A:
13.0		 3v8vA-1ws6A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 PRO A 133
PHE A  63
GLY A  65
SER A  66
GLU A  84
 None
 1.11A 5hfjD-1ws6A:
3.3		 5hfjD-1ws6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 PRO A 133
PHE A  63
GLY A  65
SER A  66
GLU A  84
 None
 1.08A 5hfjF-1ws6A:
3.5		 5hfjF-1ws6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 PHE A  63
GLY A  65
GLU A  84
VAL A 111
PRO A 133
 None
 0.80A 5hjiA-1ws6A:
undetectable		 5hjiA-1ws6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 GLU A  76
ARG A  50
LEU A  49
ARG A  56
 None
 1.16A 5l6eA-1ws6A:
2.5
5l6eB-1ws6A:
undetectable		 5l6eA-1ws6A:
20.80
5l6eB-1ws6A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 GLY A  70
ALA A 131
PHE A  59
PHE A  46
 None
 0.94A 5mvsB-1ws6A:
12.3		 5mvsB-1ws6A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1S_B_SAMB604_0
(RADICAL SAM)		 1ws6 METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 9 LEU A  19
THR A 100
ASN A  96
VAL A  30
SER A  37
 None
 1.25A 5v1sB-1ws6A:
1.3		 5v1sB-1ws6A:
18.47