SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1wsc HYPOTHETICAL PROTEIN
ST0229
(Sulfurisphaera
tokodaii) 		5 / 12 TYR A  77
ALA A  94
ILE A  93
ILE A  75
ALA A  57
 None
 1.06A 1uduB-1wscA:
undetectable		 1uduB-1wscA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1wsc HYPOTHETICAL PROTEIN
ST0229
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 157
VAL A 140
TYR A 165
GLY A 141
TRP A 167
 None
 1.26A 3mecA-1wscA:
undetectable		 3mecA-1wscA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1wsc HYPOTHETICAL PROTEIN
ST0229
(Sulfurisphaera
tokodaii) 		3 / 3 TYR A  64
LEU A  20
ARG A 203
 None
 0.73A 3sufB-1wscA:
0.0		 3sufB-1wscA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 1wsc HYPOTHETICAL PROTEIN
ST0229
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 101
PHE A 102
PRO A 103
 None
 0.58A 3zoaB-1wscA:
undetectable		 3zoaB-1wscA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 1wsc HYPOTHETICAL PROTEIN
ST0229
(Sulfurisphaera
tokodaii) 		3 / 3 LYS A 216
PRO A 217
SER A 218
 None
 0.32A 4k50I-1wscA:
undetectable		 4k50I-1wscA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1wsc HYPOTHETICAL PROTEIN
ST0229
(Sulfurisphaera
tokodaii) 		5 / 9 VAL A 161
LEU A 173
GLY A 144
LEU A 145
VAL A 140
 None
 1.24A 6czmA-1wscA:
undetectable
6czmB-1wscA:
undetectable		 6czmA-1wscA:
23.27
6czmB-1wscA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1wsc HYPOTHETICAL PROTEIN
ST0229
(Sulfurisphaera
tokodaii) 		5 / 9 VAL A 161
LEU A 173
GLY A 144
LEU A 145
VAL A 140
 None
 1.26A 6czmD-1wscA:
undetectable
6czmE-1wscA:
undetectable		 6czmD-1wscA:
23.27
6czmE-1wscA:
23.27