SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		3 / 3 ALA A 196
VAL A 347
TRP A 336
 None
 1.01A 1gmkA-1wstA:
undetectable
1gmkB-1wstA:
undetectable		 1gmkA-1wstA:
5.08
1gmkB-1wstA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		5 / 9 LEU A 119
LEU A 127
ILE A 185
VAL A 135
PHE A 154
 None
 1.31A 1gx8A-1wstA:
undetectable		 1gx8A-1wstA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 6 TRP A 265
ASP A 222
ASN A 194
SER A 226
 None
PLP  A 418 (-2.9A)
PLP  A 418 (-3.7A)
None
 1.08A 1kiaC-1wstA:
undetectable		 1kiaC-1wstA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 6 TRP A 265
GLU A 227
ILE A 219
GLY A 245
 None
 1.10A 1maaB-1wstA:
undetectable
1maaD-1wstA:
undetectable		 1maaB-1wstA:
22.93
1maaD-1wstA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 5 TRP A 265
ASP A 222
ASN A 194
SER A 226
 None
PLP  A 418 (-2.9A)
PLP  A 418 (-3.7A)
None
 1.07A 1nbhB-1wstA:
0.5		 1nbhB-1wstA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 5 TYR A 249
PRO A 103
THR A 191
THR A 235
 None
 1.34A 1ymxB-1wstA:
undetectable		 1ymxB-1wstA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 8 TYR A 187
VAL A 220
GLY A 264
THR A 252
 None
None
None
PLP  A 418 (-3.0A)
 0.85A 2a1hA-1wstA:
undetectable
2a1hB-1wstA:
undetectable		 2a1hA-1wstA:
24.94
2a1hB-1wstA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 6 ILE A 256
TRP A 265
LEU A  88
ILE A 263
 None
 0.89A 2q83B-1wstA:
0.0		 2q83B-1wstA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 5 GLU A 351
PRO A 350
ILE A 353
GLY A 352
 None
 1.10A 2qeuA-1wstA:
undetectable
2qeuC-1wstA:
undetectable		 2qeuA-1wstA:
16.59
2qeuC-1wstA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 7 PHE A 147
GLU A 136
VAL A 189
VAL A 220
 None
None
PLP  A 418 (-4.5A)
None
 1.31A 3dqrA-1wstA:
undetectable
3dqrB-1wstA:
undetectable		 3dqrA-1wstA:
21.75
3dqrB-1wstA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 7 PHE A 147
GLU A 136
VAL A 189
VAL A 220
 None
None
PLP  A 418 (-4.5A)
None
 1.31A 3jx5A-1wstA:
undetectable
3jx5B-1wstA:
undetectable		 3jx5A-1wstA:
21.75
3jx5B-1wstA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		3 / 3 GLU A  67
GLU A 300
ASN A 301
 None
 0.86A 3lp9B-1wstA:
0.0
3lp9D-1wstA:
0.0		 3lp9B-1wstA:
18.14
3lp9D-1wstA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 5 GLU A 221
GLY A 223
TYR A 100
GLU A 227
 None
 1.43A 3w9tA-1wstA:
undetectable		 3w9tA-1wstA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 5 GLU A 221
GLY A 223
TYR A 100
GLU A 227
 None
 1.43A 3w9tC-1wstA:
undetectable		 3w9tC-1wstA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 5 GLU A 221
GLY A 223
TYR A 100
GLU A 227
 None
 1.44A 3w9tD-1wstA:
undetectable		 3w9tD-1wstA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 5 GLU A 221
GLY A 223
TYR A 100
GLU A 227
 None
 1.43A 3w9tG-1wstA:
undetectable		 3w9tG-1wstA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 7 LEU A 218
ALA A 268
VAL A 112
ILE A 248
 None
 0.83A 3wsjB-1wstA:
undetectable		 3wsjB-1wstA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 7 GLU A 227
TYR A 100
HIS A 240
VAL A 107
 None
 1.11A 4a97A-1wstA:
undetectable		 4a97A-1wstA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 7 GLU A 227
TYR A 100
HIS A 240
VAL A 247
 None
 1.05A 4a97A-1wstA:
undetectable		 4a97A-1wstA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 6 GLU A 227
TYR A 100
HIS A 240
VAL A 107
 None
 1.13A 4a97E-1wstA:
undetectable		 4a97E-1wstA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 6 GLU A 227
TYR A 100
HIS A 240
VAL A 247
 None
 1.07A 4a97E-1wstA:
undetectable		 4a97E-1wstA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 7 GLU A 227
TYR A 100
HIS A 240
VAL A 107
 None
 1.12A 4a97H-1wstA:
0.0		 4a97H-1wstA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 7 GLU A 227
TYR A 100
HIS A 240
VAL A 247
 None
 1.08A 4a97H-1wstA:
0.0		 4a97H-1wstA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		3 / 3 GLU A 227
TRP A  95
LYS A 255
 None
None
PLP  A 418 (-1.3A)
 1.37A 4k7aA-1wstA:
undetectable		 4k7aA-1wstA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 8 LEU A 326
MET A 412
MET A 358
LEU A 349
 None
 0.99A 4ok1A-1wstA:
undetectable		 4ok1A-1wstA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		5 / 12 TYR A 249
LEU A 304
PHE A 253
LEU A 250
ALA A 268
 None
 1.39A 4rtbA-1wstA:
undetectable		 4rtbA-1wstA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 6 ILE A 278
GLN A 281
ILE A 283
ASP A 284
 None
 1.15A 4w5qA-1wstA:
2.6		 4w5qA-1wstA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 6 ILE A 278
GLN A 281
ILE A 283
ASP A 284
 None
 1.10A 4w5tA-1wstA:
2.6		 4w5tA-1wstA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 6 ILE A 278
GLN A 281
ILE A 283
ASP A 284
 None
 1.09A 4z4cA-1wstA:
undetectable		 4z4cA-1wstA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 6 ILE A 278
GLN A 281
ILE A 283
ASP A 284
 None
 1.20A 4z4dA-1wstA:
2.1		 4z4dA-1wstA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		5 / 12 SER A 115
GLN A 116
ALA A 142
TYR A 225
ASN A 194
 PLP  A 418 (-3.7A)
None
None
PLP  A 418 (-4.3A)
PLP  A 418 (-3.7A)
 1.42A 5cxvA-1wstA:
undetectable		 5cxvA-1wstA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		3 / 3 ASP A 222
ASN A 194
PHE A 253
 PLP  A 418 (-2.9A)
PLP  A 418 (-3.7A)
None
 0.85A 5jglB-1wstA:
2.5		 5jglB-1wstA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		5 / 12 LEU A 387
ILE A 408
LEU A 326
ALA A 362
MET A 358
 None
 1.11A 5og9B-1wstA:
undetectable		 5og9B-1wstA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 4 PHE A 147
LEU A 272
LEU A 250
VAL A 125
 None
 1.16A 5xxiA-1wstA:
undetectable		 5xxiA-1wstA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		3 / 3 ALA A 146
VAL A 220
TYR A 187
 None
 0.63A 5zmqH-1wstA:
undetectable		 5zmqH-1wstA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 4 PHE A 126
ASP A 131
LEU A 218
LYS A 184
 None
 1.31A 6awvA-1wstA:
1.5		 6awvA-1wstA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		5 / 9 ALA A  47
VAL A  43
SER A  45
VAL A 363
GLY A 400
 None
 1.26A 6bklA-1wstA:
undetectable
6bklB-1wstA:
undetectable
6bklC-1wstA:
undetectable
6bklD-1wstA:
undetectable		 6bklA-1wstA:
6.19
6bklB-1wstA:
6.19
6bklC-1wstA:
6.19
6bklD-1wstA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 6 ILE A 278
GLN A 281
ILE A 283
ASP A 284
 None
 1.16A 6cbdA-1wstA:
2.5		 6cbdA-1wstA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE
(Thermococcus
profundus) 		4 / 5 THR A 111
CYH A 286
THR A  81
GLY A  84
 None
 1.26A 6gtqA-1wstA:
undetectable		 6gtqA-1wstA:
16.79