SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		7 / 12 TYR C  41
PHE C 103
TRP A  33
VAL A  37
ASN A  50
ALA A  97
TRP A 108
 None
 0.70A 1h8sA-1wt5C:
20.7		 1h8sA-1wt5C:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		4 / 4 ALA A  92
ARG A  38
GLN A  39
GLU A  46
 None
 1.37A 1lqtB-1wt5A:
undetectable		 1lqtB-1wt5A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		4 / 4 ALA A  92
ARG A  38
GLN A  39
GLU A  46
 None
 1.36A 1lquB-1wt5A:
undetectable		 1lquB-1wt5A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		5 / 7 GLY A  54
PRO A  53
THR A  58
ILE A  51
GLY A  56
 None
 1.13A 1usqA-1wt5A:
undetectable		 1usqA-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		4 / 6 GLY A  54
PRO A  53
ILE A  51
GLY A  56
 None
 0.84A 1usqB-1wt5A:
undetectable		 1usqB-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		4 / 6 GLY A  54
PRO A  53
ILE A  51
GLY A  56
 None
 0.83A 1usqC-1wt5A:
undetectable		 1usqC-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		4 / 6 GLY A  54
PRO A  53
ILE A  51
GLY A  56
 None
 0.85A 1usqD-1wt5A:
undetectable		 1usqD-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		4 / 6 GLY A  54
PRO A  53
ILE A  51
GLY A  56
 None
 0.83A 1usqE-1wt5A:
undetectable		 1usqE-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		5 / 7 GLY A  54
PRO A  53
THR A  58
ILE A  51
GLY A  56
 None
 1.11A 1usqF-1wt5A:
undetectable		 1usqF-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		5 / 7 GLY A  54
PRO A  53
THR A  58
ILE A  51
GLY A  56
 None
 1.15A 2jkjE-1wt5A:
undetectable		 2jkjE-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		5 / 7 GLY A  54
PRO A  53
THR A  58
ILE A  51
GLY A  56
 None
 1.15A 2jklA-1wt5A:
undetectable		 2jklA-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		5 / 7 GLY A  54
PRO A  53
THR A  58
ILE A  51
GLY A  56
 None
 1.16A 2jklC-1wt5A:
undetectable		 2jklC-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		5 / 7 GLY A  54
PRO A  53
THR A  58
ILE A  51
GLY A  56
 None
 1.15A 2jklD-1wt5A:
undetectable		 2jklD-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		5 / 7 GLY A  54
PRO A  53
THR A  58
ILE A  51
GLY A  56
 None
 1.15A 2jklE-1wt5A:
undetectable		 2jklE-1wt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		5 / 7 GLY A  54
PRO A  53
THR A  58
ILE A  51
GLY A  56
 None
 1.15A 2jklF-1wt5A:
undetectable		 2jklF-1wt5A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PCP_B_1PCB227_1
(IMMUNOGLOBULIN)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		5 / 9 TYR C  37
PHE C  94
GLY C  96
HIS A  35
SER A  99
 None
 0.50A 2pcpA-1wt5C:
22.8
2pcpB-1wt5C:
15.0		 2pcpA-1wt5C:
48.77
2pcpB-1wt5C:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PCP_C_1PCC212_1
(IMMUNOGLOBULIN)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		6 / 10 HIS C  31
TYR C  37
PHE C  94
GLY C  96
HIS A  35
SER A  99
 None
 0.48A 2pcpC-1wt5C:
22.8
2pcpD-1wt5C:
15.3		 2pcpC-1wt5C:
48.77
2pcpD-1wt5C:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		5 / 12 GLN C  50
TYR C  91
GLU C  84
PRO C  64
ILE C  80
 None
 1.44A 3b7pB-1wt5C:
undetectable		 3b7pB-1wt5C:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		4 / 4 PHE A 105
TYR C  37
ARG C  59
LEU C  42
 None
 1.47A 3sueA-1wt5A:
undetectable		 3sueA-1wt5A:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens;
Homo
sapiens) 		6 / 12 HIS A  35
GLY A 100
PHE A 105
GLN C  95
GLY C  96
PRO C 101
 None
 1.27A 4uilH-1wt5A:
21.3
4uilL-1wt5A:
6.7		 4uilH-1wt5A:
40.38
4uilL-1wt5A:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens;
Homo
sapiens) 		6 / 12 HIS A  35
GLY A 101
PHE A 105
GLN C  95
GLY C  96
PRO C 101
 None
 0.93A 4uilH-1wt5A:
21.3
4uilL-1wt5A:
6.7		 4uilH-1wt5A:
40.38
4uilL-1wt5A:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens;
Homo
sapiens) 		6 / 12 TRP A  33
HIS A  35
PHE A 105
GLN C  95
GLY C  96
PRO C 101
 None
 0.76A 4uilH-1wt5A:
21.3
4uilL-1wt5A:
6.7		 4uilH-1wt5A:
40.38
4uilL-1wt5A:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens;
Homo
sapiens) 		6 / 12 HIS A  35
TRP A  47
GLY A 100
PHE A 105
GLY C  96
PRO C 101
 None
 1.18A 4uinH-1wt5A:
22.1
4uinL-1wt5A:
14.5		 4uinH-1wt5A:
35.56
4uinL-1wt5A:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens;
Homo
sapiens) 		6 / 12 HIS A  35
TRP A  47
GLY A 101
PHE A 105
GLY C  96
PRO C 101
 None
 1.15A 4uinH-1wt5A:
22.1
4uinL-1wt5A:
14.5		 4uinH-1wt5A:
35.56
4uinL-1wt5A:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens;
Homo
sapiens) 		5 / 12 TRP A  33
HIS A  35
TRP A  47
PHE A 104
PRO C 101
 None
 1.34A 4uinH-1wt5A:
22.1
4uinL-1wt5A:
14.5		 4uinH-1wt5A:
35.56
4uinL-1wt5A:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens;
Homo
sapiens) 		6 / 12 TRP A  33
HIS A  35
TRP A  47
PHE A 105
GLY C  96
PRO C 101
 None
 0.93A 4uinH-1wt5A:
22.1
4uinL-1wt5A:
14.5		 4uinH-1wt5A:
35.56
4uinL-1wt5A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1wt5 ANTI EGFR ANTIBODY
FV REGION
(Homo
sapiens) 		4 / 6 ILE C  80
TYR C  91
LEU C  11
VAL C  83
 None
 1.09A 6f6jA-1wt5C:
undetectable		 6f6jA-1wt5C:
undetectable