SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wta'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		5 / 10 GLY A  98
PHE A 175
GLY A 194
MET A 195
THR A 218
 ADE  A1300 (-3.5A)
ADE  A1300 (-4.7A)
ADE  A1300 (-3.5A)
ADE  A1300 (-4.4A)
ADE  A1300 (-4.3A)
 0.38A 1pwyE-1wtaA:
24.4		 1pwyE-1wtaA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		5 / 12 GLY A  50
ASN A  79
ILE A  74
GLY A  18
ILE A  17
 None
 0.98A 1q8jB-1wtaA:
undetectable		 1q8jB-1wtaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		5 / 12 GLY A  50
ASN A  79
SER A  44
GLY A  18
ILE A  17
 None
 1.19A 1q8jB-1wtaA:
undetectable		 1q8jB-1wtaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		5 / 10 GLY A  98
PHE A 175
GLY A 194
MET A 195
THR A 218
 ADE  A1300 (-3.5A)
ADE  A1300 (-4.7A)
ADE  A1300 (-3.5A)
ADE  A1300 (-4.4A)
ADE  A1300 (-4.3A)
 0.33A 1v3qE-1wtaA:
24.9		 1v3qE-1wtaA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		4 / 8 VAL A  91
THR A 213
SER A  95
ARG A  62
 None
None
PO4  A 400 (-2.8A)
PO4  A 400 (-3.8A)
 0.80A 2v32C-1wtaA:
undetectable
2v32D-1wtaA:
undetectable		 2v32C-1wtaA:
23.21
2v32D-1wtaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		5 / 8 GLY A  15
ALA A  58
VAL A  34
GLY A  87
ILE A  47
 None
 1.12A 3ekpA-1wtaA:
undetectable		 3ekpA-1wtaA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		5 / 12 ALA A  96
GLY A  98
GLY A 194
MET A 195
VAL A 233
 PO4  A 400 (-3.7A)
ADE  A1300 (-3.5A)
ADE  A1300 (-3.5A)
ADE  A1300 (-4.4A)
ADE  A1300 ( 4.7A)
 0.41A 3f8wA-1wtaA:
26.1		 3f8wA-1wtaA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		5 / 12 ALA A  96
GLY A  98
GLY A 194
MET A 195
VAL A 233
 PO4  A 400 (-3.7A)
ADE  A1300 (-3.5A)
ADE  A1300 (-3.5A)
ADE  A1300 (-4.4A)
ADE  A1300 ( 4.7A)
 0.36A 3f8wC-1wtaA:
26.3		 3f8wC-1wtaA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		5 / 12 HIS A  63
ALA A  96
GLY A  98
GLY A 194
VAL A 233
 PO4  A 400 (-3.8A)
PO4  A 400 (-3.7A)
ADE  A1300 (-3.5A)
ADE  A1300 (-3.5A)
ADE  A1300 ( 4.7A)
 1.08A 3f8wC-1wtaA:
26.3		 3f8wC-1wtaA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		3 / 3 ASP A 152
ARG A 156
ARG A 263
 None
 0.90A 3k37A-1wtaA:
undetectable		 3k37A-1wtaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		4 / 6 VAL A  88
LEU A 197
ILE A  74
LEU A 209
 None
 0.95A 3kk6A-1wtaA:
undetectable		 3kk6A-1wtaA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		4 / 7 TYR A 249
LEU A 146
LEU A 248
PHE A  59
 None
 1.21A 3nk2X-1wtaA:
undetectable		 3nk2X-1wtaA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		4 / 4 MET A 247
SER A 153
LEU A 150
VAL A 251
 None
 1.26A 3vlnA-1wtaA:
0.4		 3vlnA-1wtaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		4 / 6 ALA A  82
GLY A  15
LEU A  86
VAL A  88
 None
 0.93A 4dubA-1wtaA:
undetectable		 4dubA-1wtaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		4 / 6 ALA A  82
GLY A  15
LEU A  86
VAL A  88
 None
 0.93A 4dubB-1wtaA:
undetectable		 4dubB-1wtaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		5 / 12 PRO A 141
GLY A 165
ILE A 192
PHE A 115
LEU A 197
 None
 1.49A 4kovA-1wtaA:
undetectable		 4kovA-1wtaA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		4 / 8 SER A  95
SER A  93
TYR A 167
ILE A 201
 PO4  A 400 (-2.8A)
None
None
None
 1.09A 4ms4A-1wtaA:
2.4		 4ms4A-1wtaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		3 / 3 ARG A  62
TYR A 211
GLU A 200
 PO4  A 400 (-3.8A)
None
None
 0.50A 4zzbE-1wtaA:
undetectable		 4zzbE-1wtaA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		5 / 11 SER A  95
ARG A  62
ALA A 215
THR A 213
ALA A 204
 PO4  A 400 (-2.8A)
PO4  A 400 (-3.8A)
None
None
None
 1.40A 6efnA-1wtaA:
undetectable		 6efnA-1wtaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Aeropyrum
pernix) 		3 / 3 LYS A  56
VAL A  49
ASP A  51
 None
 0.48A 6fgdA-1wtaA:
2.2		 6fgdA-1wtaA:
22.04