SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 VAL A 319
VAL A 254
VAL A 185
ASN A 308
LEU A 315
 None
 1.18A 1fe2A-1wu2A:
undetectable		 1fe2A-1wu2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 TYR A 375
LEU A 369
LEU A 370
SER A 372
LEU A 219
 None
 1.14A 1fmlA-1wu2A:
undetectable		 1fmlA-1wu2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 LEU A 376
ALA A 374
VAL A 328
VAL A 391
ILE A 393
 None
 0.97A 1hsgA-1wu2A:
undetectable		 1hsgA-1wu2A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A 369
LEU A 219
GLY A 218
ILE A 214
 None
 0.90A 1n13A-1wu2A:
undetectable
1n13F-1wu2A:
undetectable		 1n13A-1wu2A:
10.47
1n13F-1wu2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 LEU A 376
ALA A 374
VAL A 328
VAL A 391
ILE A 393
 None
 0.89A 1t3rB-1wu2A:
undetectable		 1t3rB-1wu2A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 TYR A  10
LEU A  17
ILE A 281
SER A 297
PHE A 287
 None
 1.47A 1xlxA-1wu2A:
undetectable		 1xlxA-1wu2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 TYR A  10
LEU A  17
ILE A 281
SER A 297
PHE A 287
 None
 1.42A 1xomA-1wu2A:
undetectable		 1xomA-1wu2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 TYR A  10
LEU A  17
ILE A 281
SER A 297
PHE A 287
 None
 1.41A 1xomB-1wu2A:
undetectable		 1xomB-1wu2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 PHE A 307
VAL A 220
LEU A  18
ILE A  21
PHE A 294
 None
 1.27A 1yatA-1wu2A:
undetectable		 1yatA-1wu2A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_A_TOPA1290_1
(PTERIDINE REDUCTASE
1)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 PHE A 294
LEU A  14
LEU A  18
HIS A 313
TYR A  10
 None
 1.30A 2bfmA-1wu2A:
1.7
2bfmD-1wu2A:
2.3		 2bfmA-1wu2A:
19.95
2bfmD-1wu2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 LEU A  17
PHE A 307
PHE A 294
ILE A  21
 None
 0.89A 2opxA-1wu2A:
2.2		 2opxA-1wu2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 ILE A 214
LEU A 369
LEU A 219
GLY A 218
 None
 0.91A 2qqdB-1wu2A:
undetectable
2qqdC-1wu2A:
undetectable		 2qqdB-1wu2A:
18.54
2qqdC-1wu2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 LEU A 376
ALA A 374
VAL A 328
VAL A 391
ILE A 393
 None
 0.94A 3em3B-1wu2A:
undetectable		 3em3B-1wu2A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 376
ALA A 374
VAL A 328
VAL A 391
ILE A 393
 None
 0.98A 3em6B-1wu2A:
undetectable		 3em6B-1wu2A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 330
LEU A 332
ILE A 378
PRO A 379
SER A 382
 None
 1.21A 3nrrB-1wu2A:
undetectable		 3nrrB-1wu2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 LEU A 376
ALA A 374
VAL A 328
VAL A 391
ILE A 393
 None
 1.03A 3oxwD-1wu2A:
undetectable		 3oxwD-1wu2A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 LEU A 376
ALA A 374
VAL A 328
VAL A 391
ILE A 393
 None
 0.93A 3oy4A-1wu2A:
undetectable		 3oy4A-1wu2A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_SALA1505_1
(FERROCHELATASE,
MITOCHONDRIAL)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 VAL A 391
SER A 338
LEU A 376
PRO A 379
SER A 382
 None
 1.31A 3w1wA-1wu2A:
2.4
3w1wB-1wu2A:
2.8		 3w1wA-1wu2A:
20.96
3w1wB-1wu2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 376
ALA A 374
VAL A 328
VAL A 391
ILE A 393
 None
 0.90A 4dqbA-1wu2A:
undetectable		 4dqbA-1wu2A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 LEU A 376
ALA A 374
VAL A 328
VAL A 391
ILE A 393
 None
 0.88A 4dqhA-1wu2A:
undetectable		 4dqhA-1wu2A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 HIS A 313
TYR A  10
TYR A 375
GLU A 325
ARG A  11
 None
 1.35A 4jd1A-1wu2A:
undetectable
4jd1B-1wu2A:
undetectable		 4jd1A-1wu2A:
17.63
4jd1B-1wu2A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 PRO A 183
VAL A 319
MET A 318
ALA A 316
 None
 1.05A 4lb2A-1wu2A:
undetectable		 4lb2A-1wu2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 ALA A 374
VAL A 328
VAL A 391
ILE A 393
 None
 0.73A 4ll3A-1wu2A:
undetectable		 4ll3A-1wu2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 LEU A 376
GLU A 389
ARG A 386
ILE A 336
GLY A 384
 None
 1.35A 5ifuB-1wu2A:
2.8		 5ifuB-1wu2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 ALA A 305
PHE A 294
GLY A 288
PHE A 287
GLY A 284
 None
 1.26A 6awoA-1wu2A:
undetectable		 6awoA-1wu2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 ALA A 305
PHE A 294
GLY A 288
PHE A 287
GLY A 284
 None
 1.26A 6awqA-1wu2A:
undetectable		 6awqA-1wu2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ILE A 188
ASN A 249
CYH A 251
 None
 0.92A 6bp4A-1wu2A:
undetectable		 6bp4A-1wu2A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 HIS A 277
VAL A 272
LEU A 274
ALA A 268
 None
 1.24A 6d8pB-1wu2A:
3.3		 6d8pB-1wu2A:
19.60