SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wu7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 ARG A 110
TYR A 269
TYR A 270
TYR A 293
GLY A 309
 None
 1.07A 1httB-1wu7A:
32.5		 1httB-1wu7A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 GLU A  81
THR A  83
ARG A 110
TYR A 293
GLY A 309
 None
 0.91A 1httB-1wu7A:
32.5		 1httB-1wu7A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		6 / 12 GLU A  81
THR A  83
GLN A 124
GLY A 290
TYR A 293
GLY A 309
 None
 1.01A 1httB-1wu7A:
32.5		 1httB-1wu7A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 THR A  83
ARG A 110
TYR A 270
TYR A 293
GLY A 309
 None
 0.93A 1httB-1wu7A:
32.5		 1httB-1wu7A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		6 / 12 THR A  83
GLN A 124
TYR A 270
GLY A 290
TYR A 293
GLY A 309
 None
 0.91A 1httB-1wu7A:
32.5		 1httB-1wu7A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 TYR A 269
TYR A 270
GLY A 290
TYR A 293
GLY A 309
 None
 0.80A 1httB-1wu7A:
32.5		 1httB-1wu7A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		6 / 12 GLU A  81
THR A  83
GLN A 124
GLY A 290
TYR A 293
GLY A 309
 None
 1.04A 1httC-1wu7A:
32.8		 1httC-1wu7A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		6 / 12 THR A  83
GLN A 124
TYR A 270
GLY A 290
TYR A 293
GLY A 309
 None
 1.03A 1httC-1wu7A:
32.8		 1httC-1wu7A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 TYR A 269
TYR A 270
GLY A 290
TYR A 293
GLY A 309
 None
 0.87A 1httC-1wu7A:
32.8		 1httC-1wu7A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 GLU A  81
THR A  83
GLN A 124
GLY A 290
GLY A 309
 None
 1.03A 1httD-1wu7A:
32.6		 1httD-1wu7A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 THR A  83
GLN A 124
TYR A 270
GLY A 290
GLY A 309
 None
 0.96A 1httD-1wu7A:
32.6		 1httD-1wu7A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A  19
ASP A  21
LYS A 322
 None
 1.11A 1lqtB-1wu7A:
4.3		 1lqtB-1wu7A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A  19
ASP A  21
LYS A 322
 None
 1.10A 1lquB-1wu7A:
undetectable		 1lquB-1wu7A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 7 PHE A  39
PHE A 310
SER A 147
ARG A 151
 None
 1.04A 1rqpB-1wu7A:
undetectable		 1rqpB-1wu7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 8 PHE A  39
PHE A 310
SER A 147
ARG A 151
 None
 1.09A 1rqpC-1wu7A:
undetectable		 1rqpC-1wu7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 8 PHE A  39
PHE A 310
SER A 147
ARG A 151
 None
 1.10A 1rqpA-1wu7A:
undetectable		 1rqpA-1wu7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 7 LEU A 202
GLY A 174
ILE A 171
VAL A 212
ILE A 207
 None
 1.27A 2aojB-1wu7A:
undetectable		 2aojB-1wu7A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 317
ALA A 127
GLY A 311
GLY A 313
PHE A  39
 None
 1.16A 2okcB-1wu7A:
undetectable		 2okcB-1wu7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 8 PHE A  39
PHE A 310
SER A 147
ARG A 151
 None
 1.06A 2v7uA-1wu7A:
undetectable		 2v7uA-1wu7A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 7 PHE A  39
PHE A 310
SER A 147
ARG A 151
 None
 1.03A 2v7uB-1wu7A:
undetectable		 2v7uB-1wu7A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 8 ASP A 260
SER A 262
ILE A 263
HIS A 191
 None
 1.10A 2xadA-1wu7A:
undetectable		 2xadA-1wu7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 8 ASP A 260
SER A 262
ILE A 263
HIS A 191
 None
 1.10A 2xadB-1wu7A:
undetectable		 2xadB-1wu7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 8 ASP A 260
SER A 262
ILE A 263
HIS A 191
 None
 1.09A 2xadD-1wu7A:
undetectable		 2xadD-1wu7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 5 ARG A 323
ASP A 279
ILE A 287
GLU A 324
 None
 1.46A 2xrzA-1wu7A:
undetectable
2xrzB-1wu7A:
undetectable		 2xrzA-1wu7A:
23.23
2xrzB-1wu7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 11 PRO A 135
SER A 134
VAL A 308
VAL A 141
ILE A 273
 None
 1.28A 3rf4A-1wu7A:
0.9
3rf4C-1wu7A:
undetectable		 3rf4A-1wu7A:
15.06
3rf4C-1wu7A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 11 ILE A 273
PRO A 135
SER A 134
VAL A 308
VAL A 141
 None
 1.31A 3rf4A-1wu7A:
0.9
3rf4B-1wu7A:
0.7		 3rf4A-1wu7A:
15.06
3rf4B-1wu7A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 11 ILE A 273
PRO A 135
SER A 134
VAL A 308
VAL A 141
 None
 1.30A 3rf4B-1wu7A:
0.7
3rf4C-1wu7A:
undetectable		 3rf4B-1wu7A:
15.06
3rf4C-1wu7A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 8 ILE A 337
ILE A 343
LEU A 414
VAL A 417
 None
 0.69A 3ua5A-1wu7A:
undetectable		 3ua5A-1wu7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 7 ILE A 337
ILE A 343
LEU A 414
VAL A 417
 None
 0.74A 3ua5B-1wu7A:
undetectable		 3ua5B-1wu7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 142
GLY A 290
TYR A 293
VAL A 308
ALA A 307
 None
 1.12A 4fqsA-1wu7A:
0.0		 4fqsA-1wu7A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 142
GLY A 290
TYR A 293
VAL A 308
ALA A 307
 None
 1.12A 4fqsB-1wu7A:
0.0		 4fqsB-1wu7A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 317
VAL A 316
LEU A 320
ALA A 286
LEU A 288
 None
 1.01A 4m11B-1wu7A:
undetectable		 4m11B-1wu7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 317
ALA A 145
LEU A 149
LEU A 152
LEU A 154
 None
 0.90A 4o1zA-1wu7A:
undetectable		 4o1zA-1wu7A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 317
VAL A 316
LEU A 320
ALA A 286
LEU A 288
 None
 1.05A 4o1zB-1wu7A:
0.0		 4o1zB-1wu7A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 6 ASN A 163
MET A 168
TYR A 270
GLU A 276
 None
 1.37A 4r87H-1wu7A:
undetectable		 4r87H-1wu7A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 5 SER A 182
ARG A 203
GLY A 208
GLU A 209
 None
 1.18A 5cdqA-1wu7A:
undetectable
5cdqB-1wu7A:
undetectable
5cdqC-1wu7A:
undetectable		 5cdqA-1wu7A:
22.65
5cdqB-1wu7A:
20.65
5cdqC-1wu7A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 5 SER A 182
ARG A 203
GLY A 208
GLU A 209
 None
 1.18A 5cdqR-1wu7A:
undetectable
5cdqS-1wu7A:
undetectable
5cdqT-1wu7A:
3.0		 5cdqR-1wu7A:
22.65
5cdqS-1wu7A:
20.65
5cdqT-1wu7A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 GLU A  81
THR A  83
GLY A 290
TYR A 293
GLY A 309
 None
 0.96A 5e3iA-1wu7A:
31.1		 5e3iA-1wu7A:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		6 / 12 THR A  83
GLN A 124
TYR A 270
GLY A 290
TYR A 293
GLY A 309
 None
 1.01A 5e3iA-1wu7A:
31.1		 5e3iA-1wu7A:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 TYR A 269
TYR A 270
GLY A 290
TYR A 293
GLY A 309
 None
 0.87A 5e3iA-1wu7A:
31.1		 5e3iA-1wu7A:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 11 GLU A  81
THR A  83
GLY A 290
TYR A 293
GLY A 309
 None
 0.96A 5e3iB-1wu7A:
30.8		 5e3iB-1wu7A:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		6 / 11 THR A  83
GLN A 124
TYR A 270
GLY A 290
TYR A 293
GLY A 309
 None
 1.02A 5e3iB-1wu7A:
30.8		 5e3iB-1wu7A:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 11 TYR A 269
TYR A 270
GLY A 290
TYR A 293
GLY A 309
 None
 0.88A 5e3iB-1wu7A:
30.8		 5e3iB-1wu7A:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 7 VAL A 212
SER A 213
ALA A 216
VAL A 199
 None
 0.73A 5fpdA-1wu7A:
undetectable		 5fpdA-1wu7A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		4 / 7 VAL A 212
SER A 213
ALA A 216
VAL A 199
 None
 0.73A 5fpdB-1wu7A:
undetectable		 5fpdB-1wu7A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1wu7 HISTIDYL-TRNA
SYNTHETASE
(Thermoplasma
acidophilum) 		5 / 12 TYR A 351
HIS A 420
VAL A 412
VAL A 399
SER A 416
 None
 1.12A 5n0oA-1wu7A:
undetectable		 5n0oA-1wu7A:
21.68