SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		5 / 12 ASP A 112
ARG A 150
ILE A 109
ASP A  90
ILE A 131
 None
 1.35A 1kijA-1wu8A:
undetectable		 1kijA-1wu8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		4 / 7 ASP A 179
PHE A 181
ASN A 183
SER A 226
 None
 1.09A 1rqpB-1wu8A:
26.5		 1rqpB-1wu8A:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		5 / 8 ASP A 179
PHE A 181
ASN A 183
SER A 226
ALA A 233
 None
 1.12A 1rqpC-1wu8A:
26.9		 1rqpC-1wu8A:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		5 / 8 ASP A 179
PHE A 181
ASN A 183
SER A 226
ALA A 233
 None
 1.11A 1rqpA-1wu8A:
26.8		 1rqpA-1wu8A:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		3 / 3 ASP A 228
GLU A 210
TYR A 212
 None
 0.78A 1wsvA-1wu8A:
undetectable		 1wsvA-1wu8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		5 / 9 ALA A  29
GLY A 142
ILE A 143
VAL A  64
ILE A   2
 None
 0.94A 2q5kA-1wu8A:
undetectable		 2q5kA-1wu8A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		5 / 8 ASP A 179
PHE A 181
ASN A 183
SER A 226
ALA A 233
 None
 1.10A 2v7uA-1wu8A:
26.7		 2v7uA-1wu8A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		4 / 7 ASP A 179
PHE A 181
ASN A 183
SER A 226
 None
 1.09A 2v7uB-1wu8A:
26.6		 2v7uB-1wu8A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1300_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		6 / 9 ASP A 179
PHE A 181
ASN A 183
SER A 226
ALA A 233
ASN A 235
 None
 1.09A 2v7uC-1wu8A:
26.8		 2v7uC-1wu8A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ0_A_ACRA801_1
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		5 / 12 ILE A 176
GLU A  51
HIS A 100
LYS A  99
GLU A 163
 None
 1.38A 2zq0A-1wu8A:
0.0		 2zq0A-1wu8A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		5 / 10 ILE A 152
ILE A  78
GLY A  92
PRO A  97
VAL A 103
 None
 1.20A 3elzC-1wu8A:
undetectable		 3elzC-1wu8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		5 / 10 ALA A  29
GLY A 142
ILE A 143
VAL A  64
ILE A   2
 None
 0.94A 3nu6A-1wu8A:
undetectable		 3nu6A-1wu8A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		4 / 8 TYR A  85
VAL A  87
ILE A 109
GLU A 140
 None
 1.09A 4a97D-1wu8A:
undetectable		 4a97D-1wu8A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		4 / 8 TYR A  85
VAL A  87
ILE A 109
GLU A 140
 None
 1.10A 4a97G-1wu8A:
undetectable		 4a97G-1wu8A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		4 / 7 TYR A  85
VAL A  87
ILE A 109
GLU A 140
 None
 1.11A 4a97H-1wu8A:
undetectable		 4a97H-1wu8A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA305_0
(THAUMATIN-1)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		4 / 5 LYS A  99
GLU A  51
ILE A 176
PHE A  48
 None
 1.14A 4tvtA-1wu8A:
0.0		 4tvtA-1wu8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		5 / 11 GLU A 146
GLU A 147
GLY A 136
ALA A 135
VAL A  62
 None
 1.14A 5yk2A-1wu8A:
undetectable		 5yk2A-1wu8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 1wu8 HYPOTHETICAL PROTEIN
PH0463
(Pyrococcus
horikoshii) 		4 / 5 HIS A 227
GLU A 189
LEU A 160
VAL A 162
 None
 1.19A 6bc9A-1wu8A:
undetectable		 6bc9A-1wu8A:
13.67