SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wue'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		3 / 3 GLN A1149
TYR A1169
ARG A1166
 None
 0.73A 1gtbA-1wueA:
undetectable		 1gtbA-1wueA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 8 GLY A1349
GLY A1046
PHE A1045
GLY A1298
 None
 0.76A 1jhqA-1wueA:
undetectable		 1jhqA-1wueA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 8 GLY A1349
GLY A1046
PHE A1045
GLY A1298
 None
 0.77A 1jhvA-1wueA:
undetectable		 1jhvA-1wueA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 7 ASP A1110
GLY A1298
ALA A1273
ILE A1270
 None
 0.77A 1n49A-1wueA:
undetectable		 1n49A-1wueA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 11 TYR A1360
GLU A1294
LEU A1033
ILE A1328
ASP A1327
 None
 1.32A 1t6zB-1wueA:
undetectable		 1t6zB-1wueA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 GLN A1304
LEU A1301
ILE A1036
GLY A1347
LEU A1076
 None
 1.05A 1vptA-1wueA:
undetectable		 1vptA-1wueA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 11 LEU A1076
LEU A1077
ILE A1068
MET A1367
LEU A1111
 None
 1.20A 2ft9A-1wueA:
undetectable		 2ft9A-1wueA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A1128
GLN A1159
PRO A1132
 None
 0.96A 2qhfA-1wueA:
undetectable		 2qhfA-1wueA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		3 / 3 ASN A1191
ASP A1239
ARG A1299
 None
 0.93A 3k13A-1wueA:
5.8		 3k13A-1wueA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 LEU A1210
ALA A1211
ARG A1178
ILE A1135
GLY A1134
 None
 1.05A 3q95B-1wueA:
undetectable		 3q95B-1wueA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 10 ARG A1266
VAL A1267
ALA A1277
VAL A1287
ILE A1242
 None
 1.45A 3retA-1wueA:
undetectable
3retB-1wueA:
undetectable		 3retA-1wueA:
15.49
3retB-1wueA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 PRO A1173
LEU A1202
ILE A1165
TYR A1194
PHE A1217
 None
 1.42A 4a79A-1wueA:
undetectable		 4a79A-1wueA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 5 THR A1106
GLY A1269
VAL A1267
PRO A1265
 None
 1.14A 4grkA-1wueA:
undetectable		 4grkA-1wueA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 8 SER A1119
LEU A1120
PHE A1124
PRO A1343
 None
 1.09A 4j7uD-1wueA:
undetectable		 4j7uD-1wueA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 7 MET A1099
VAL A1057
PHE A1051
GLU A1064
 None
 1.35A 4jseA-1wueA:
undetectable
4jseB-1wueA:
undetectable		 4jseA-1wueA:
24.31
4jseB-1wueA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 7 PHE A1051
GLU A1064
MET A1099
VAL A1057
 None
 1.37A 4jseA-1wueA:
0.0
4jseB-1wueA:
0.0		 4jseA-1wueA:
24.31
4jseB-1wueA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 11 GLY A1168
ARG A1166
ALA A1193
ILE A1260
LEU A1285
 None
 1.13A 4kt0A-1wueA:
undetectable
4kt0J-1wueA:
undetectable		 4kt0A-1wueA:
18.44
4kt0J-1wueA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 11 LEU A1210
ALA A1211
ARG A1178
ILE A1135
GLY A1134
 None
 1.08A 4pxmB-1wueA:
undetectable		 4pxmB-1wueA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 ALA A1107
ALA A1300
ILE A1348
ILE A1328
LEU A1352
 None
 1.21A 4r3aA-1wueA:
undetectable		 4r3aA-1wueA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 GLU A1122
ILE A1348
ALA A1300
VAL A1297
PHE A1045
 None
 1.13A 4u95B-1wueA:
undetectable		 4u95B-1wueA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 5 GLY A1269
THR A1106
GLY A1100
GLU A1105
 None
 1.17A 4v20A-1wueA:
undetectable		 4v20A-1wueA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 5 VAL A1154
ILE A1264
PRO A1314
THR A1127
 None
 1.14A 4ze1A-1wueA:
undetectable		 4ze1A-1wueA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 12 LEU A1210
ALA A1211
ARG A1178
ILE A1135
GLY A1134
 None
 1.13A 5gs4A-1wueA:
undetectable		 5gs4A-1wueA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 7 LEU A1075
VAL A1087
GLU A1105
ILE A1366
 None
 1.13A 5jh7C-1wueA:
3.2		 5jh7C-1wueA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		3 / 3 LYS A1148
LEU A1184
ILE A1135
 None
 0.77A 5kc0A-1wueA:
undetectable		 5kc0A-1wueA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		3 / 3 ASP A1239
ASN A1261
ASP A1316
 None
 0.87A 5vopB-1wueA:
5.2		 5vopB-1wueA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 4 GLY A1046
LEU A1033
VAL A1297
GLU A1047
 None
 1.45A 5yw0A-1wueA:
0.0		 5yw0A-1wueA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		3 / 3 MET A1187
ASP A1316
ARG A1266
 None
 1.12A 5z6jA-1wueA:
undetectable		 5z6jA-1wueA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		3 / 3 MET A1187
ASP A1316
ARG A1266
 None
 1.07A 5z6kA-1wueA:
undetectable		 5z6kA-1wueA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 10 VAL A1267
LEU A1301
ASN A1302
ILE A1270
THR A1106
 None
 1.35A 6d9hR-1wueA:
undetectable		 6d9hR-1wueA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 6 PRO A1309
GLN A1308
ARG A1128
ILE A1131
 None
 1.48A 6ef6A-1wueA:
0.0		 6ef6A-1wueA:
25.62