SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wuu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 4 GLY A  71
LEU A  72
GLY A 124
ARG A  68
 None
 1.27A 1j7kA-1wuuA:
undetectable		 1j7kA-1wuuA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 5 HIS A 311
ARG A 312
ILE A 285
HIS A  44
 None
None
None
GLA  A 393 (-3.6A)
 1.48A 1osvB-1wuuA:
0.0		 1osvB-1wuuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 6 LEU A 380
ALA A 219
LEU A 221
SER A 341
 None
 0.81A 1tz8C-1wuuA:
undetectable
1tz8D-1wuuA:
undetectable		 1tz8C-1wuuA:
17.66
1tz8D-1wuuA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 LEU A 139
SER A 140
LEU A 135
GLY A 136
GLY A 137
 None
ANP  A 395 ( 3.1A)
ANP  A 395 (-4.3A)
ANP  A 395 (-3.4A)
ANP  A 395 (-4.6A)
 0.91A 1uakA-1wuuA:
undetectable		 1uakA-1wuuA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 THR A 344
GLY A 138
GLY A 137
SER A 140
MET A 185
 None
ANP  A 395 (-2.9A)
ANP  A 395 (-4.6A)
ANP  A 395 ( 3.1A)
None
 1.15A 1wg8A-1wuuA:
undetectable		 1wg8A-1wuuA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 5 SER A 132
VAL A 130
SER A 144
VAL A 133
 None
 1.34A 2j9cA-1wuuA:
4.3
2j9cB-1wuuA:
4.2
2j9cC-1wuuA:
3.6		 2j9cA-1wuuA:
15.87
2j9cB-1wuuA:
15.87
2j9cC-1wuuA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 8 LEU A 206
ARG A 166
PRO A  54
GLY A 193
 None
 0.97A 2po5A-1wuuA:
undetectable		 2po5A-1wuuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 GLY A 349
GLY A 347
CYH A 351
ASP A 326
THR A 344
 None
 1.14A 2vdvE-1wuuA:
undetectable		 2vdvE-1wuuA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 GLY A  36
ILE A 222
ALA A  34
ALA A 143
VAL A  38
 None
 0.94A 2yqzB-1wuuA:
undetectable		 2yqzB-1wuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 8 VAL A 320
ASP A 326
GLY A 349
HIS A 311
 None
 1.01A 3af0A-1wuuA:
0.0		 3af0A-1wuuA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 11 GLY A 350
THR A 223
ILE A 222
LEU A 139
THR A 344
 None
 1.33A 3bexC-1wuuA:
undetectable
3bexD-1wuuA:
undetectable		 3bexC-1wuuA:
20.49
3bexD-1wuuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 10 LEU A 139
THR A 344
GLY A 350
THR A 223
ILE A 222
 None
 1.33A 3bexC-1wuuA:
undetectable
3bexD-1wuuA:
undetectable		 3bexC-1wuuA:
20.49
3bexD-1wuuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 10 GLY A 350
THR A 223
ILE A 222
LEU A 139
THR A 344
 None
 1.33A 3bexE-1wuuA:
undetectable
3bexF-1wuuA:
undetectable		 3bexE-1wuuA:
20.49
3bexF-1wuuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 11 LEU A 139
THR A 344
GLY A 350
THR A 223
ILE A 222
 None
 1.33A 3bexE-1wuuA:
undetectable
3bexF-1wuuA:
undetectable		 3bexE-1wuuA:
20.49
3bexF-1wuuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 11 GLY A 350
THR A 223
ILE A 222
LEU A 139
THR A 344
 None
 1.32A 3bf1A-1wuuA:
undetectable
3bf1B-1wuuA:
undetectable		 3bf1A-1wuuA:
20.49
3bf1B-1wuuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 11 GLY A 350
THR A 223
ILE A 222
LEU A 139
THR A 344
 None
 1.34A 3bf1C-1wuuA:
undetectable
3bf1D-1wuuA:
undetectable		 3bf1C-1wuuA:
20.49
3bf1D-1wuuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 11 LEU A 139
THR A 344
GLY A 350
THR A 223
ILE A 222
 None
 1.34A 3bf1C-1wuuA:
undetectable
3bf1D-1wuuA:
undetectable		 3bf1C-1wuuA:
20.49
3bf1D-1wuuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 11 GLY A 350
THR A 223
ILE A 222
LEU A 139
THR A 344
 None
 1.36A 3bf1E-1wuuA:
undetectable
3bf1F-1wuuA:
undetectable		 3bf1E-1wuuA:
20.49
3bf1F-1wuuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 11 LEU A 139
THR A 344
GLY A 350
THR A 223
ILE A 222
 None
 1.32A 3bf1E-1wuuA:
undetectable
3bf1F-1wuuA:
undetectable		 3bf1E-1wuuA:
20.49
3bf1F-1wuuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 LEU A 210
GLY A 386
ILE A 189
GLY A  36
ASP A 385
 None
 0.98A 3bwcB-1wuuA:
undetectable		 3bwcB-1wuuA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 7 LEU A 153
GLY A  65
ALA A 127
PHE A  20
 None
 0.83A 3tehB-1wuuA:
3.1		 3tehB-1wuuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 6 GLU A  43
GLY A 346
LEU A 314
TYR A 318
 GLA  A 393 (-3.7A)
GLA  A 393 ( 3.4A)
None
None
 0.82A 3w9tB-1wuuA:
undetectable		 3w9tB-1wuuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 6 GLU A  43
GLY A 346
LEU A 314
TYR A 318
 GLA  A 393 (-3.7A)
GLA  A 393 ( 3.4A)
None
None
 0.82A 3w9tE-1wuuA:
undetectable		 3w9tE-1wuuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 6 GLU A  43
GLY A 346
LEU A 314
TYR A 318
 GLA  A 393 (-3.7A)
GLA  A 393 ( 3.4A)
None
None
 0.80A 3w9tF-1wuuA:
undetectable		 3w9tF-1wuuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 LEU A 295
ALA A 292
LEU A 200
ILE A 201
GLY A  50
 None
 1.04A 4dm8B-1wuuA:
undetectable		 4dm8B-1wuuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 LEU A 333
VAL A 338
PHE A 378
LEU A  40
THR A 352
 None
 1.42A 4iaqA-1wuuA:
2.0		 4iaqA-1wuuA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 11 GLY A 193
ALA A 383
LEU A  57
GLY A  36
ILE A 368
 None
 1.07A 4kt0A-1wuuA:
undetectable
4kt0J-1wuuA:
undetectable		 4kt0A-1wuuA:
20.84
4kt0J-1wuuA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 HIS A  44
THR A  45
ASP A 186
GLY A  42
MET A 185
 GLA  A 393 (-3.6A)
None
GLA  A 393 (-3.2A)
None
None
 1.48A 4pfjA-1wuuA:
undetectable		 4pfjA-1wuuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 ALA A 387
ALA A 164
ILE A 163
ILE A 201
LEU A 199
 None
 1.01A 4r3aB-1wuuA:
undetectable		 4r3aB-1wuuA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 6 ARG A 279
ARG A 277
ASP A 317
VAL A 270
 None
 1.40A 4xqeA-1wuuA:
undetectable		 4xqeA-1wuuA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 6 ARG A 279
ARG A 277
ASP A 317
VAL A 270
 None
 1.41A 4xqeB-1wuuA:
undetectable		 4xqeB-1wuuA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 LEU A 139
SER A 140
LEU A 135
GLY A 136
GLY A 137
 None
ANP  A 395 ( 3.1A)
ANP  A 395 (-4.3A)
ANP  A 395 (-3.4A)
ANP  A 395 (-4.6A)
 0.89A 4yvgA-1wuuA:
undetectable		 4yvgA-1wuuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 7 PHE A 188
ILE A 163
ASP A 385
GLY A 386
 None
 0.91A 5h3aA-1wuuA:
undetectable		 5h3aA-1wuuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 GLY A 350
HIS A 311
GLU A 330
ILE A 368
TYR A 372
 None
 1.21A 5igvA-1wuuA:
undetectable		 5igvA-1wuuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1wuu GALACTOKINASE
(Homo
sapiens) 		3 / 3 VAL A 133
LEU A 325
MET A 343
 None
 0.82A 5ikrA-1wuuA:
0.8		 5ikrA-1wuuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 12 HIS A  44
THR A  45
ASP A 186
GLY A  42
MET A 185
 GLA  A 393 (-3.6A)
None
GLA  A 393 (-3.2A)
None
None
 1.48A 5m66D-1wuuA:
undetectable		 5m66D-1wuuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 8 ALA A 143
SER A  33
THR A 151
GLY A  36
 None
 0.96A 5v0vA-1wuuA:
undetectable		 5v0vA-1wuuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 1wuu GALACTOKINASE
(Homo
sapiens) 		4 / 6 PHE A 188
ILE A 163
ASP A 385
GLY A 386
 None
 0.95A 5x5qE-1wuuA:
undetectable		 5x5qE-1wuuA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1wuu GALACTOKINASE
(Homo
sapiens) 		5 / 11 GLY A 345
GLY A 347
LEU A 314
VAL A 320
ASP A  46
 ANP  A 395 (-3.5A)
None
None
None
GLA  A 393 (-3.0A)
 1.24A 6i5zD-1wuuA:
undetectable		 6i5zD-1wuuA:
20.70