SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 ILE A1204
LEU A1183
GLY A1239
VAL A1213
ALA A1212
 None
 1.12A 1tlsA-1wv2A:
0.0		 1tlsA-1wv2A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 ILE A1204
LEU A1183
GLY A1239
VAL A1213
ALA A1212
 None
 1.06A 1tlsB-1wv2A:
undetectable		 1tlsB-1wv2A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 8 ARG A1016
PHE A1011
LEU A1191
LEU A1077
LEU A1105
 None
 1.49A 2bfpC-1wv2A:
undetectable		 2bfpC-1wv2A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		3 / 3 LEU A1163
LEU A1152
PHE A1118
 None
 0.73A 2pgrA-1wv2A:
6.1		 2pgrA-1wv2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 GLY A1195
GLY A1168
ALA A1218
LEU A1214
VAL A1213
 None
 0.91A 2yqzB-1wv2A:
undetectable		 2yqzB-1wv2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		4 / 4 GLY A1168
GLY A1195
GLY A1165
GLY A1170
 None
 0.58A 3bogC-1wv2A:
0.0		 3bogC-1wv2A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		4 / 4 GLY A1168
GLY A1195
GLY A1165
GLY A1170
 None
 0.63A 3bogD-1wv2A:
0.0		 3bogD-1wv2A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 ALA A1044
SER A1042
ASP A1193
LEU A1214
TYR A1141
 None
 0.97A 3k2hA-1wv2A:
undetectable		 3k2hA-1wv2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 ALA A1044
SER A1042
ASP A1193
LEU A1214
TYR A1141
 None
 0.97A 3k2hB-1wv2A:
undetectable		 3k2hB-1wv2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 ALA A1044
SER A1042
ASP A1193
LEU A1214
TYR A1141
 None
 1.01A 3nrrA-1wv2A:
undetectable		 3nrrA-1wv2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 ALA A1044
SER A1042
ASP A1193
LEU A1214
TYR A1141
 None
 1.00A 3nrrB-1wv2A:
undetectable		 3nrrB-1wv2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1208
ALA A1164
ASP A1193
VAL A1213
GLY A1197
 None
 0.81A 3so9B-1wv2A:
undetectable		 3so9B-1wv2A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 10 ALA A1096
LEU A1100
LEU A1105
ASN A1104
ILE A1076
 None
 1.16A 3wdmD-1wv2A:
undetectable		 3wdmD-1wv2A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1131
PHE A1136
VAL A1106
ALA A1096
GLU A1088
 None
 1.25A 4fiaA-1wv2A:
undetectable		 4fiaA-1wv2A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1131
PHE A1136
VAL A1106
ALA A1096
GLU A1088
 None
 1.25A 4fiaA-1wv2A:
undetectable		 4fiaA-1wv2A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 SER A1042
ILE A1219
ASP A1193
LEU A1214
TYR A1141
 None
 1.33A 4foxE-1wv2A:
0.0		 4foxE-1wv2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 VAL A1160
LEU A1108
VAL A1138
ALA A1127
LEU A1152
 None
 1.17A 4i1rA-1wv2A:
undetectable		 4i1rA-1wv2A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		6 / 12 GLY A1172
GLY A1197
ASP A1201
ILE A1204
ALA A1164
LEU A1179
 None
 1.46A 4iv8A-1wv2A:
undetectable		 4iv8A-1wv2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		6 / 12 GLY A1172
GLY A1197
ASP A1201
ILE A1204
ALA A1164
LEU A1179
 None
 1.44A 4iv8B-1wv2A:
undetectable		 4iv8B-1wv2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		4 / 6 LEU A1244
GLU A1207
VAL A1213
ALA A1212
 None
 1.16A 4nkvC-1wv2A:
undetectable		 4nkvC-1wv2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		5 / 12 ALA A1231
MET A1228
ALA A1038
ALA A1044
GLY A1043
 None
 0.97A 4oaeA-1wv2A:
undetectable		 4oaeA-1wv2A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		3 / 3 LEU A1152
THR A1080
ASN A1079
 None
 0.70A 6baaE-1wv2A:
undetectable		 6baaE-1wv2A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		3 / 3 LEU A1152
THR A1080
ASN A1079
 None
 0.70A 6baaF-1wv2A:
undetectable		 6baaF-1wv2A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		3 / 3 LEU A1152
THR A1080
ASN A1079
 None
 0.71A 6baaG-1wv2A:
undetectable		 6baaG-1wv2A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG
(Pseudomonas
aeruginosa) 		3 / 3 LEU A1152
THR A1080
ASN A1079
 None
 0.71A 6baaH-1wv2A:
undetectable		 6baaH-1wv2A:
10.44