SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 11 THR A  32
LEU A 241
GLY A  24
VAL A  14
VAL A  38
 None
 1.19A 1akdA-1wvgA:
undetectable		 1akdA-1wvgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 11 THR A  32
LEU A 241
GLY A  24
VAL A  14
VAL A  38
 None
 1.13A 1phgA-1wvgA:
undetectable		 1phgA-1wvgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 7 LEU A  51
GLY A 341
VAL A  55
ILE A  54
 None
 0.75A 2aojB-1wvgA:
undetectable		 2aojB-1wvgA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 LYS A 136
ASP A 203
ASN A 197
 CXY  A 401 (-2.8A)
None
CXY  A 401 (-2.9A)
 1.18A 2bm9A-1wvgA:
4.8		 2bm9A-1wvgA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 11 MET A  89
LEU A  27
ALA A 195
SER A 242
LEU A 241
 APR  A 400 (-4.9A)
None
None
None
None
 1.31A 2c12F-1wvgA:
undetectable		 2c12F-1wvgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 12 GLY A  18
GLY A  21
LEU A  43
GLY A  66
ALA A  90
 APR  A 400 (-3.2A)
APR  A 400 (-3.2A)
APR  A 400 (-4.1A)
None
APR  A 400 (-3.4A)
 0.82A 2fk8A-1wvgA:
5.1		 2fk8A-1wvgA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 11 GLY A  35
ALA A  36
ILE A   4
PHE A  87
VAL A  14
 None
 1.06A 2fxdA-1wvgA:
undetectable		 2fxdA-1wvgA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 8 LEU A  74
ALA A  79
GLY A 124
ILE A 126
 None
 0.73A 2o4nB-1wvgA:
undetectable		 2o4nB-1wvgA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 4 SER A  28
GLY A  24
HIS A  64
ASP A  70
 None
 1.24A 2oxtC-1wvgA:
5.0		 2oxtC-1wvgA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 ASN A 197
ARG A 232
ASP A 157
 CXY  A 401 (-2.9A)
CXY  A 401 (-3.5A)
None
 0.87A 2qe6A-1wvgA:
undetectable		 2qe6A-1wvgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 ASN A 197
ARG A 232
ASP A 157
 CXY  A 401 (-2.9A)
CXY  A 401 (-3.5A)
None
 0.92A 2qe6B-1wvgA:
undetectable		 2qe6B-1wvgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 6 ASN A 140
ALA A 302
HIS A 300
ASP A 157
 None
 1.06A 3aruA-1wvgA:
3.9		 3aruA-1wvgA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 5 VAL A 130
VAL A 129
PHE A 258
ARG A  13
 None
 1.39A 3bjwB-1wvgA:
undetectable		 3bjwB-1wvgA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 4 GLU A 269
GLY A 323
THR A 325
GLU A 326
 None
 1.22A 3e9xA-1wvgA:
undetectable		 3e9xA-1wvgA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		6 / 12 VAL A  14
ALA A  36
LEU A  57
THR A  32
LEU A  27
PHE A  87
 None
 1.17A 3gp0A-1wvgA:
undetectable		 3gp0A-1wvgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 ASN A 131
LEU A  74
PHE A  87
 None
 0.77A 4dajB-1wvgA:
undetectable		 4dajB-1wvgA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 7 HIS A  19
GLY A  40
ALA A  90
TYR A  41
 None
None
APR  A 400 (-3.4A)
None
 0.85A 4hyfA-1wvgA:
undetectable		 4hyfA-1wvgA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 8 HIS A  19
GLY A  40
ALA A  90
TYR A  41
 None
None
APR  A 400 (-3.4A)
None
 0.88A 4hyfB-1wvgA:
undetectable		 4hyfB-1wvgA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 8 HIS A  19
GLY A  40
ALA A  90
TYR A  41
 None
None
APR  A 400 (-3.4A)
None
 0.84A 4hyfC-1wvgA:
undetectable		 4hyfC-1wvgA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 4 HIS A 335
GLU A 351
HIS A 236
LEU A 324
 None
 0.97A 4m2rA-1wvgA:
undetectable		 4m2rA-1wvgA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 5 GLY A 202
ASP A 203
GLU A 218
VAL A 223
 None
 1.06A 4nkvD-1wvgA:
undetectable		 4nkvD-1wvgA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 9 SER A  28
GLU A  33
LEU A 241
LEU A 238
 None
 0.72A 4xtaA-1wvgA:
undetectable		 4xtaA-1wvgA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 12 VAL A  55
GLY A 201
SER A 348
ILE A 210
HIS A 335
 None
 1.48A 4xueB-1wvgA:
5.4		 4xueB-1wvgA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 4 GLY A 124
VAL A 188
PHE A  87
ILE A  85
 None
 1.14A 4xv2B-1wvgA:
undetectable		 4xv2B-1wvgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 9 THR A  32
LEU A 241
GLY A  24
VAL A  14
VAL A  38
 None
 1.20A 5cp4A-1wvgA:
undetectable		 5cp4A-1wvgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 ARG A 148
VAL A 144
TRP A 143
 None
 1.25A 5fvoA-1wvgA:
undetectable		 5fvoA-1wvgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 7 ASP A 268
ALA A 271
LEU A 324
TRP A 234
 None
 1.04A 5nwvA-1wvgA:
0.0		 5nwvA-1wvgA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 THR A 133
MET A  89
HIS A  88
 None
APR  A 400 (-4.9A)
None
 0.80A 5uunA-1wvgA:
undetectable		 5uunA-1wvgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		3 / 3 ARG A 208
ARG A 232
ARG A  96
 APR  A 400 ( 2.6A)
CXY  A 401 (-3.5A)
None
 0.96A 5vcgA-1wvgA:
undetectable		 5vcgA-1wvgA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 5 HIS A 335
GLU A 351
HIS A 236
LEU A 324
 None
 0.97A 6bc9A-1wvgA:
undetectable		 6bc9A-1wvgA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		5 / 10 THR A 325
ILE A 277
PHE A 276
ILE A 199
ILE A 331
 None
 1.12A 6ebpD-1wvgA:
undetectable		 6ebpD-1wvgA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 1wvg CDP-GLUCOSE
4,6-DEHYDRATASE
(Salmonella
enterica) 		4 / 4 MET A  89
GLY A  18
HIS A  19
GLY A  24
 APR  A 400 (-4.9A)
APR  A 400 (-3.2A)
None
None
 1.23A 6fgdA-1wvgA:
1.6		 6fgdA-1wvgA:
21.43