SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wwk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 THR A 268
LEU A 267
VAL A 240
 None
 0.68A 1mz9E-1wwkA:
undetectable		 1mz9E-1wwkA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 187
GLY A 151
GLY A 148
ILE A 145
THR A 141
 None
None
NAD  A1001 (-3.2A)
None
None
 1.08A 1p91B-1wwkA:
6.2		 1p91B-1wwkA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 8 ALA A 160
LEU A 161
LEU A 137
VAL A 196
ILE A 226
 None
 1.43A 2uxpA-1wwkA:
undetectable		 2uxpA-1wwkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 ALA A 281
GLY A 291
SER A  96
ALA A  95
 NAD  A1001 (-4.1A)
None
NAD  A1001 ( 3.9A)
None
 0.85A 2vh3B-1wwkA:
undetectable		 2vh3B-1wwkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A 107
THR A 276
THR A 198
HIS A 200
 None
 1.36A 2zj0C-1wwkA:
14.6		 2zj0C-1wwkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 8 LEU A 275
THR A 276
GLY A 106
ALA A 104
THR A 198
 None
 1.35A 3jusB-1wwkA:
undetectable		 3jusB-1wwkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 275
THR A 276
GLY A 106
ALA A 104
THR A 198
 None
 1.35A 3jusB-1wwkA:
undetectable		 3jusB-1wwkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 8 LEU A  64
VAL A 298
LEU A 302
ILE A  46
VAL A   3
 None
 1.42A 3kp6A-1wwkA:
undetectable
3kp6B-1wwkA:
undetectable		 3kp6A-1wwkA:
18.61
3kp6B-1wwkA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		6 / 12 GLY A 252
VAL A 273
GLY A 250
ALA A 104
GLY A 106
ILE A 224
 None
 1.49A 3ku1A-1wwkA:
6.9		 3ku1A-1wwkA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 11 ALA A 223
VAL A 196
ILE A 248
GLY A 250
SER A 194
 None
 1.01A 3kw2B-1wwkA:
3.0		 3kw2B-1wwkA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 253
THR A 276
LEU A 103
HIS A 200
LEU A 107
 None
 1.18A 3q1eB-1wwkA:
undetectable
3q1eD-1wwkA:
0.0		 3q1eB-1wwkA:
15.59
3q1eD-1wwkA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  68
ILE A  14
LEU A  17
VAL A  39
VAL A   3
 None
 1.08A 3rukA-1wwkA:
undetectable		 3rukA-1wwkA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 302
GLY A  21
ALA A  20
ILE A  14
VAL A 299
 None
 0.89A 3u7sA-1wwkA:
undetectable		 3u7sA-1wwkA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 11 VAL A 154
ALA A 101
GLY A 146
ILE A 165
GLY A 148
 None
None
NAD  A1001 (-3.5A)
None
NAD  A1001 (-3.2A)
 1.08A 3zosA-1wwkA:
undetectable
3zosB-1wwkA:
undetectable		 3zosA-1wwkA:
23.71
3zosB-1wwkA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 302
GLY A  21
ALA A  20
ILE A  14
VAL A 298
 None
 0.87A 4dqbB-1wwkA:
undetectable		 4dqbB-1wwkA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 302
GLY A  21
ALA A  20
ILE A  14
VAL A 298
 None
 0.87A 4dqeB-1wwkA:
undetectable		 4dqeB-1wwkA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 302
GLY A  21
ALA A  20
ILE A  14
VAL A 298
 None
 0.91A 4dqhB-1wwkA:
undetectable		 4dqhB-1wwkA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 MET A 219
LEU A 191
LEU A 166
ILE A 211
ILE A 199
 None
 1.21A 4j24B-1wwkA:
undetectable		 4j24B-1wwkA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A   7
ARG A  69
ALA A  68
ALA A 290
GLY A 291
 None
 0.94A 4oaeA-1wwkA:
undetectable		 4oaeA-1wwkA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 143
ILE A 165
ALA A 155
PHE A 147
HIS A 200
 None
 1.22A 4wh5A-1wwkA:
undetectable		 4wh5A-1wwkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 275
THR A 236
LEU A 239
LEU A 267
 None
 0.76A 4z90F-1wwkA:
0.0
4z90G-1wwkA:
0.0
4z90H-1wwkA:
0.0
4z90I-1wwkA:
0.0
4z90J-1wwkA:
0.0		 4z90F-1wwkA:
17.70
4z90G-1wwkA:
17.70
4z90H-1wwkA:
17.70
4z90I-1wwkA:
17.70
4z90J-1wwkA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A  67
ALA A   6
VAL A  47
VAL A  57
 None
 0.72A 5eclD-1wwkA:
undetectable		 5eclD-1wwkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 137
ALA A 112
LEU A 253
PHE A 109
LEU A 239
 None
 1.12A 5ljeA-1wwkA:
undetectable		 5ljeA-1wwkA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A 252
LEU A 253
LEU A 210
VAL A 234
GLY A 250
 None
 1.01A 5vkqB-1wwkA:
undetectable
5vkqC-1wwkA:
undetectable		 5vkqB-1wwkA:
10.65
5vkqC-1wwkA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 1wwk PHOSPHOGLYCERATE
DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 302
GLY A  21
ALA A  20
ILE A  14
VAL A 299
 None
 0.89A 6dh0A-1wwkA:
undetectable		 6dh0A-1wwkA:
15.49