SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		4 / 6 LEU A 104
TRP A 135
LEU A 145
PHE A  88
 None
 1.47A 1ru9H-1wwlA:
undetectable
1ru9L-1wwlA:
undetectable		 1ru9H-1wwlA:
22.15
1ru9L-1wwlA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		3 / 3 LEU A  91
LEU A  94
SER A  97
 None
 0.56A 1tlmA-1wwlA:
undetectable		 1tlmA-1wwlA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		4 / 5 LEU A 128
LEU A 142
LEU A 164
LEU A 145
 None
 1.11A 1yajD-1wwlA:
undetectable		 1yajD-1wwlA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		4 / 8 LEU A 267
LEU A 260
VAL A 221
GLY A 220
 None
 0.78A 2po5A-1wwlA:
undetectable		 2po5A-1wwlA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		4 / 8 LEU A 267
LEU A 260
VAL A 221
GLY A 220
 None
 0.81A 2po5B-1wwlA:
undetectable		 2po5B-1wwlA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		4 / 8 LEU A  40
PRO A 123
SER A  97
GLY A  89
 None
 1.11A 2qd5B-1wwlA:
undetectable		 2qd5B-1wwlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		5 / 12 LEU A 130
ALA A 161
LEU A 182
LEU A 164
LEU A 142
 None
 1.23A 3erdA-1wwlA:
undetectable		 3erdA-1wwlA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		4 / 7 LEU A  40
PRO A 123
SER A  97
GLY A  89
 None
 1.07A 3hcrB-1wwlA:
undetectable		 3hcrB-1wwlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		4 / 4 LEU A 180
ALA A 196
PHE A 166
ASN A 185
 None
 1.28A 3vasA-1wwlA:
undetectable		 3vasA-1wwlA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		5 / 12 PRO A 298
LEU A 281
LEU A 262
LEU A 267
GLN A 269
 None
 1.05A 4a7aB-1wwlA:
undetectable		 4a7aB-1wwlA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		5 / 11 LEU A 260
VAL A 221
LEU A 225
LEU A 274
LEU A 257
 None
 1.28A 4or0B-1wwlA:
undetectable		 4or0B-1wwlA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		4 / 7 LEU A 232
ALA A 228
ALA A 224
LEU A 235
 None
 0.67A 4z90F-1wwlA:
undetectable
4z90G-1wwlA:
undetectable
4z90H-1wwlA:
undetectable
4z90J-1wwlA:
undetectable		 4z90F-1wwlA:
22.82
4z90G-1wwlA:
22.82
4z90H-1wwlA:
22.82
4z90J-1wwlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		5 / 12 LEU A 130
ALA A 161
LEU A 182
LEU A 164
LEU A 142
 None
 1.23A 4zn7A-1wwlA:
undetectable		 4zn7A-1wwlA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		5 / 9 LEU A  94
GLY A  98
VAL A  38
LEU A  75
ARG A  74
 None
 1.41A 5o96E-1wwlA:
undetectable
5o96F-1wwlA:
0.0		 5o96E-1wwlA:
20.90
5o96F-1wwlA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		5 / 12 ALA A  80
LEU A  40
PHE A  30
LEU A  87
ALA A  90
 None
 1.07A 6djzC-1wwlA:
undetectable		 6djzC-1wwlA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		4 / 5 LEU A 128
LEU A  91
THR A  76
ARG A  81
 None
 1.03A 6ew0F-1wwlA:
undetectable		 6ew0F-1wwlA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Mus
musculus) 		4 / 6 LEU A 128
LEU A  91
THR A  76
ARG A  81
 None
 1.03A 6ew0G-1wwlA:
undetectable		 6ew0G-1wwlA:
12.70