SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 1wwr TRNA ADENOSINE
DEAMINASE TADA
(Aquifex
aeolicus) 		5 / 11 LEU A  89
ALA A  57
GLY A  26
VAL A  25
VAL A  97
 None
 0.96A 3oxxD-1wwrA:
undetectable		 3oxxD-1wwrA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1wwr TRNA ADENOSINE
DEAMINASE TADA
(Aquifex
aeolicus) 		4 / 6 LEU A 139
SER A 100
PRO A 131
PHE A  99
 None
 1.30A 5b8iA-1wwrA:
undetectable		 5b8iA-1wwrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1wwr TRNA ADENOSINE
DEAMINASE TADA
(Aquifex
aeolicus) 		3 / 3 TYR A 130
ALA A  10
LEU A  11
 None
 0.58A 6ag0C-1wwrA:
undetectable		 6ag0C-1wwrA:
16.95