SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus)
3 / 3 GLU A   9
LYS A   4
VAL A   5
None
0.92A 1l2iA-1wwsA:
undetectable
1l2iA-1wwsA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus)
4 / 6 LEU A  40
GLU A  57
ILE A  62
PRO A  61
None
1.07A 2fcnA-1wwsA:
undetectable
2fcnB-1wwsA:
undetectable
2fcnA-1wwsA:
19.44
2fcnB-1wwsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus)
6 / 12 VAL A 121
ALA A  16
ALA A  15
LEU A  11
PHE A  12
LEU A  18
None
1.12A 3fc6C-1wwsA:
undetectable
3fc6C-1wwsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus)
3 / 3 ARG A  75
GLU A 109
ASP A 102
None
0.81A 3g2oA-1wwsA:
undetectable
3g2oA-1wwsA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus)
5 / 12 LEU A  39
LEU A  36
LEU A   2
ILE A  62
GLN A  67
None
1.12A 4f4dA-1wwsA:
undetectable
4f4dA-1wwsA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus)
4 / 5 VAL A 103
ARG A 104
GLU A 101
LEU A  54
None
1.49A 4hojA-1wwsA:
undetectable
4hojA-1wwsA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus)
4 / 6 LEU A  89
ARG A  33
VAL A  85
LEU A   2
None
0.93A 5x7zA-1wwsA:
undetectable
5x7zA-1wwsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus)
4 / 6 VAL A  85
LEU A  36
LEU A  40
LEU A 106
None
1.04A 6f6sA-1wwsA:
undetectable
6f6sB-1wwsA:
undetectable
6f6sA-1wwsA:
24.65
6f6sB-1wwsA:
19.21