SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wwz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RMT_A_ADNA1501_1 (CLASS B ACID PHOSPHATASE)	1wwz	HYPOTHETICAL PROTEIN PH1933 (Pyrococcus horikoshii)	5 / 10	PHE A 139 LEU A 111 GLY A 103 ARG A 104 TYR A 136	None None ACO A1001 (-3.4A) ACO A1001 (-4.2A) None	1.02A	1rmtA-1wwzA: 0.3	1rmtA-1wwzA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	1wwz	HYPOTHETICAL PROTEIN PH1933 (Pyrococcus horikoshii)	5 / 12	LEU A 107 ILE A 121 GLU A 90 CYH A 49 GLY A 56	None None ACO A1001 (-3.9A) None None	1.28A	4hfpB-1wwzA: undetectable	4hfpB-1wwzA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PUO_C_NVPC901_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	1wwz	HYPOTHETICAL PROTEIN PH1933 (Pyrococcus horikoshii)	4 / 8	LEU A 20 VAL A 71 VAL A 92 LEU A 9	None None ACO A1001 (-3.5A) None	1.04A	4puoC-1wwzA: undetectable	4puoC-1wwzA: 16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FCT_B_C2FB402_1 (THYMIDYLATE SYNTHASE)	1wwz	HYPOTHETICAL PROTEIN PH1933 (Pyrococcus horikoshii)	3 / 3	ASN A 118 ASP A 55 GLY A 56	None	0.55A	5fctB-1wwzA: undetectable	5fctB-1wwzA: 20.26

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RMT_A_ADNA1501_1","CLASS B ACID PHOSPHATASE","1wwz","HYPOTHETICAL PROTEIN PH1933","Pyrococcus horikoshii",5,"PHE A 139;LEU A 111;GLY A 103;ARG A 104;TYR A 136","None;None;ACO A1001 (-3.4A);ACO A1001 (-4.2A);None","1.02A","1rmtA-1wwzA:0.3","1rmtA-1wwzA:22.12"],["4HFP_B_15UB402_1","PROTHROMBIN","1wwz","HYPOTHETICAL PROTEIN PH1933","Pyrococcus horikoshii",5,"LEU A 107;ILE A 121;GLU A  90;CYH A  49;GLY A  56","None;None;ACO A1001 (-3.9A);None;None","1.28A","4hfpB-1wwzA:undetectable","4hfpB-1wwzA:21.32"],["4PUO_C_NVPC901_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","1wwz","HYPOTHETICAL PROTEIN PH1933","Pyrococcus horikoshii",4,"LEU A  20;VAL A  71;VAL A  92;LEU A   9","None;None;ACO A1001 (-3.5A);None","1.04A","4puoC-1wwzA:undetectable","4puoC-1wwzA:16.04"],["5FCT_B_C2FB402_1","THYMIDYLATE SYNTHASE","1wwz","HYPOTHETICAL PROTEIN PH1933","Pyrococcus horikoshii",3,"ASN A 118;ASP A  55;GLY A  56","None","0.55A","5fctB-1wwzA:undetectable","5fctB-1wwzA:20.26"]]