SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wx0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 1wx0 TRANSALDOLASE
(Thermus
thermophilus) 		5 / 9 ILE A 174
LEU A 139
ALA A 184
VAL A 180
MET A   1
 None
 1.32A 1ctrA-1wx0A:
undetectable		 1ctrA-1wx0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1wx0 TRANSALDOLASE
(Thermus
thermophilus) 		5 / 12 LEU A  22
ALA A 191
GLY A  61
THR A   7
MET A 193
 None
 1.08A 3c6gA-1wx0A:
undetectable		 3c6gA-1wx0A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 1wx0 TRANSALDOLASE
(Thermus
thermophilus) 		5 / 12 GLY A 187
ALA A 188
ASP A 189
ILE A 170
VAL A 135
 None
 0.89A 3ekqA-1wx0A:
undetectable		 3ekqA-1wx0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 1wx0 TRANSALDOLASE
(Thermus
thermophilus) 		5 / 11 ARG A 154
LEU A 186
ALA A 171
GLY A 140
VAL A 142
 None
 1.27A 3oxxB-1wx0A:
undetectable		 3oxxB-1wx0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 1wx0 TRANSALDOLASE
(Thermus
thermophilus) 		5 / 12 THR A  26
THR A 116
ALA A 172
ARG A 141
PHE A 138
 None
 1.17A 4pbhA-1wx0A:
undetectable		 4pbhA-1wx0A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 1wx0 TRANSALDOLASE
(Thermus
thermophilus) 		4 / 6 LEU A   5
LEU A  22
SER A  23
VAL A 180
 None
 1.25A 5a6iA-1wx0A:
undetectable		 5a6iA-1wx0A:
22.32