SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ARG A 129
ALA A 124
ALA A 154
GLU A 158
 None
 1.25A 1e7bA-1wxdA:
undetectable		 1e7bA-1wxdA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ARG A 129
ALA A 124
ALA A 156
GLU A 158
 None
 1.09A 1e7bA-1wxdA:
undetectable		 1e7bA-1wxdA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ARG A 129
ALA A 124
ALA A 154
GLU A 158
 None
 1.26A 1e7bB-1wxdA:
undetectable		 1e7bB-1wxdA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 242
LEU A 246
MET A 253
LEU A  24
THR A  99
 None
 1.20A 2oaxA-1wxdA:
0.0		 2oaxA-1wxdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 PHE A 196
LEU A 122
LEU A 215
ALA A 218
 None
 0.92A 2vcvB-1wxdA:
undetectable		 2vcvB-1wxdA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 GLY A 126
GLY A 128
VAL A 176
GLU A  65
ILE A  81
 ACT  A1301 ( 4.3A)
None
None
ACT  A1301 (-3.6A)
None
 1.13A 3owxA-1wxdA:
5.0		 3owxA-1wxdA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 ALA A 202
VAL A 203
ASP A 204
LEU A 205
LEU A 122
 None
 1.28A 3roxA-1wxdA:
5.8		 3roxA-1wxdA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ALA A 138
LEU A 140
LEU A 175
PHE A 196
LEU A 105
 None
 1.14A 3zosA-1wxdA:
undetectable
3zosB-1wxdA:
undetectable		 3zosA-1wxdA:
23.78
3zosB-1wxdA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 103
SER A  14
VAL A  11
ASN A  58
VAL A   6
 None
 1.47A 4ffwA-1wxdA:
undetectable		 4ffwA-1wxdA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A  67
LEU A  94
ASP A 100
ASN A  98
TYR A  33
 None
 0.93A 4pclA-1wxdA:
4.9		 4pclA-1wxdA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 SER A  32
ALA A   5
VAL A   6
 None
 0.57A 4x20C-1wxdA:
2.4		 4x20C-1wxdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 PRO A 250
PRO A 248
GLY A 228
THR A 227
ALA A 257
 None
 1.28A 5vyhA-1wxdA:
undetectable		 5vyhA-1wxdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ILE A  81
ARG A 151
ALA A 124
LEU A 155
ALA A 154
 None
SO4  A1403 (-3.8A)
None
None
None
 1.07A 5zgbB-1wxdA:
0.0		 5zgbB-1wxdA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGH_B_PQNB843_1
(PSAB)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ILE A  81
ARG A 151
ALA A 124
LEU A 155
ALA A 154
 None
SO4  A1403 (-3.8A)
None
None
None
 1.06A 5zghB-1wxdA:
undetectable		 5zghB-1wxdA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 VAL A 203
ASN A 177
GLY A 123
LEU A 122
VAL A 131
 None
 1.23A 6czmA-1wxdA:
undetectable
6czmB-1wxdA:
undetectable		 6czmA-1wxdA:
23.37
6czmB-1wxdA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 VAL A 203
ASN A 177
GLY A 123
LEU A 122
VAL A 131
 None
 1.25A 6czmE-1wxdA:
undetectable
6czmF-1wxdA:
undetectable		 6czmE-1wxdA:
23.37
6czmF-1wxdA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1wxd SHIKIMATE
5-DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ARG A 151
ALA A 124
LEU A 155
ALA A 154
 SO4  A1403 (-3.8A)
None
None
None
 1.23A 6fosB-1wxdA:
undetectable		 6fosB-1wxdA:
15.73