SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		5 / 12 ALA A 145
GLY A 155
GLY A 151
ILE A 149
ILE A  40
 None
 1.03A 1x1aA-1wxfA:
3.5		 1x1aA-1wxfA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 6 ASN A 188
ILE A  17
GLU A 239
LYS A  14
 None
 1.48A 3kp6A-1wxfA:
0.0
3kp6B-1wxfA:
0.0		 3kp6A-1wxfA:
22.94
3kp6B-1wxfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 7 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.10A 4feuB-1wxfA:
undetectable		 4feuB-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.08A 4feuD-1wxfA:
undetectable		 4feuD-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.07A 4feuF-1wxfA:
undetectable		 4feuF-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 7 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.12A 4fevB-1wxfA:
undetectable		 4fevB-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 7 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.12A 4fevD-1wxfA:
undetectable		 4fevD-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 7 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.11A 4fevF-1wxfA:
undetectable		 4fevF-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 7 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.11A 4fewB-1wxfA:
undetectable		 4fewB-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.14A 4fewD-1wxfA:
undetectable		 4fewD-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.13A 4fewF-1wxfA:
undetectable		 4fewF-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 7 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.15A 4fexB-1wxfA:
undetectable		 4fexB-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.14A 4gkhB-1wxfA:
undetectable		 4gkhB-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.11A 4gkhD-1wxfA:
undetectable		 4gkhD-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.15A 4gkhF-1wxfA:
undetectable		 4gkhF-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 7 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.14A 4gkhG-1wxfA:
undetectable		 4gkhG-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 6 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.12A 4gkhJ-1wxfA:
undetectable		 4gkhJ-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.11A 4gkhC-1wxfA:
undetectable
4gkhK-1wxfA:
undetectable		 4gkhC-1wxfA:
21.62
4gkhK-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.14A 4gkiA-1wxfA:
undetectable		 4gkiA-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.13A 4gkiC-1wxfA:
undetectable		 4gkiC-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		4 / 8 ASP A  52
ASP A 161
ASP A 235
GLU A 165
 None
 1.13A 4gkiE-1wxfA:
undetectable
4gkiG-1wxfA:
undetectable		 4gkiE-1wxfA:
21.62
4gkiG-1wxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 1wxf NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Escherichia
coli) 		5 / 10 ILE A 181
LEU A  59
LEU A 187
PHE A  29
GLU A  22
 None
 1.32A 5tixB-1wxfA:
undetectable		 5tixB-1wxfA:
24.07