SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wxq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 THR A 303
GLU A 307
THR A 249
VAL A   5
 None
 0.94A 2fb2A-1wxqA:
2.4		 2fb2A-1wxqA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ILE A 157
GLU A 165
PHE A 206
VAL A 182
ALA A 169
 None
 1.44A 2jj8D-1wxqA:
0.4		 2jj8D-1wxqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 HIS A 107
ILE A 138
LEU A  96
 None
 0.72A 2kceA-1wxqA:
undetectable		 2kceA-1wxqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LYS A 114
SER A 228
GLN A 231
 None
 0.64A 3si7A-1wxqA:
undetectable		 3si7A-1wxqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 SER A 228
ASP A 110
ASP A 116
 None
 0.91A 3uj7A-1wxqA:
undetectable		 3uj7A-1wxqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 GLU A  63
PRO A  72
ILE A  71
LEU A  70
 None
 1.13A 5m45A-1wxqA:
2.3		 5m45A-1wxqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 GLU A  63
PRO A  72
ILE A  71
LEU A  70
 None
 1.17A 5m45D-1wxqA:
2.4		 5m45D-1wxqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 GLU A  63
PRO A  72
ILE A  71
LEU A  70
 None
 1.12A 5m45G-1wxqA:
2.4		 5m45G-1wxqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 GLU A  63
PRO A  72
ILE A  71
LEU A  70
 None
 1.22A 5m45J-1wxqA:
undetectable		 5m45J-1wxqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 312
ASP A 315
LEU A 134
LEU A 105
ALA A 104
 None
 1.16A 5nd7B-1wxqA:
2.1		 5nd7B-1wxqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 GLY A  40
VAL A   5
ASP A  77
THR A  42
ILE A 309
 None
 1.19A 6exiA-1wxqA:
2.7		 6exiA-1wxqA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1wxq GTP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 GLY A  40
VAL A   5
ASP A  77
THR A  42
ILE A 309
 None
 1.21A 6exiB-1wxqA:
undetectable		 6exiB-1wxqA:
13.50