SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 10 LEU A  55
GLY A 107
PRO A 106
HIS A  17
GLU A 370
 None
 1.12A 1equA-1wxxA:
7.1		 1equA-1wxxA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 10 LEU A  97
LEU A  80
ALA A  79
LEU A 105
HIS A 362
 None
 1.19A 1gwrA-1wxxA:
undetectable		 1gwrA-1wxxA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 8 ALA A 340
LYS A 355
ALA A 377
THR A 323
 None
 0.72A 1ie4B-1wxxA:
undetectable
1ie4D-1wxxA:
undetectable		 1ie4B-1wxxA:
15.77
1ie4D-1wxxA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 11 LEU A 130
ALA A 121
LEU A  76
GLN A 132
HIS A 124
 None
 1.30A 1qabE-1wxxA:
0.0		 1qabE-1wxxA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 GLY A 221
VAL A 259
ALA A 236
ALA A 247
ARG A 246
 None
 1.45A 2avdA-1wxxA:
17.9		 2avdA-1wxxA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 7 ARG A 272
LEU A 273
PRO A 287
VAL A 216
 None
 1.24A 2hrcA-1wxxA:
undetectable		 2hrcA-1wxxA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 PHE A 217
SER A 240
ALA A 243
ALA A 266
PRO A 288
 None
 0.48A 2igtA-1wxxA:
21.2		 2igtA-1wxxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 PHE A 217
SER A 240
ALA A 243
ALA A 266
PRO A 288
 None
 0.43A 2igtB-1wxxA:
21.2		 2igtB-1wxxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 PHE A 217
SER A 240
ALA A 243
ALA A 266
PRO A 288
 None
 0.45A 2igtC-1wxxA:
21.0		 2igtC-1wxxA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 5 LEU A 315
ALA A 311
LEU A 285
MET A 205
 None
 1.22A 2oaxA-1wxxA:
undetectable		 2oaxA-1wxxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 VAL A 184
TYR A 113
VAL A 118
VAL A 162
ASP A 149
 None
 1.26A 2x0yA-1wxxA:
undetectable		 2x0yA-1wxxA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 7 GLY A 115
ASP A 111
TYR A 112
ARG A  96
 None
 1.19A 3arrA-1wxxA:
undetectable		 3arrA-1wxxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 7 GLY A 115
ASP A 111
TYR A 112
ARG A  96
 None
 1.22A 3aruA-1wxxA:
undetectable		 3aruA-1wxxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 ARG A 202
ASP A 238
SER A 240
ALA A 266
ASP A 286
 None
 0.54A 3axtA-1wxxA:
17.7		 3axtA-1wxxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 6 VAL A 234
VAL A 235
PHE A 223
ARG A 260
 None
 1.15A 3bjwF-1wxxA:
undetectable		 3bjwF-1wxxA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		3 / 3 ASP A 197
GLU A 177
SER A 327
 None
 0.78A 3p2kA-1wxxA:
9.7		 3p2kA-1wxxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 6 VAL A 184
ASN A 250
TYR A 182
TYR A 113
 None
 1.16A 3q5sA-1wxxA:
undetectable		 3q5sA-1wxxA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB802_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 ARG A 202
PHE A 217
SER A 240
ASP A 286
PRO A 288
 None
 0.65A 3v8vB-1wxxA:
24.8		 3v8vB-1wxxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 8 PHE A 335
TYR A 304
VAL A 339
ILE A 312
ASN A 308
 None
 1.30A 4a97D-1wxxA:
undetectable		 4a97D-1wxxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 7 PHE A 335
TYR A 304
VAL A 339
ILE A 312
ASN A 308
 None
 1.39A 4a97H-1wxxA:
undetectable		 4a97H-1wxxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 8 PHE A 335
TYR A 304
VAL A 339
ILE A 312
ASN A 308
 None
 1.35A 4a97I-1wxxA:
undetectable		 4a97I-1wxxA:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 ARG A 202
ASP A 238
ALA A 266
ASP A 286
PRO A 288
 None
 0.41A 4dmgA-1wxxA:
41.8		 4dmgA-1wxxA:
39.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 TYR A 195
ARG A 202
ASP A 238
ALA A 266
ASP A 286
 None
 0.95A 4dmgA-1wxxA:
41.8		 4dmgA-1wxxA:
39.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DMG_B_SAMB401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		6 / 11 TYR A 195
ARG A 202
ASP A 238
ALA A 266
ASP A 286
PRO A 288
 None
 0.97A 4dmgB-1wxxA:
41.2		 4dmgB-1wxxA:
39.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 GLY A 221
GLY A 222
SER A 240
ASP A 286
PRO A 288
 None
 0.57A 4fp9A-1wxxA:
13.9		 4fp9A-1wxxA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 GLY A 221
GLY A 222
SER A 240
ASP A 286
PRO A 288
 None
 0.56A 4fp9C-1wxxA:
13.1		 4fp9C-1wxxA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 GLY A 221
GLY A 222
SER A 240
ASP A 286
PRO A 288
 None
 0.56A 4fp9F-1wxxA:
13.9		 4fp9F-1wxxA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 5 PHE A 208
TYR A 204
THR A 323
ILE A 320
 None
 0.89A 4jx1E-1wxxA:
undetectable		 4jx1E-1wxxA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 8 ALA A 125
GLY A 128
LEU A 129
LEU A  72
 PO4  A1506 ( 4.5A)
PO4  A1506 ( 4.4A)
None
None
 0.89A 4po0A-1wxxA:
undetectable		 4po0A-1wxxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 6 ALA A  77
GLN A  78
LEU A  80
LEU A 105
 None
 1.07A 4xoyA-1wxxA:
undetectable		 4xoyA-1wxxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 PHE A 217
GLY A 222
ALA A 266
ASP A 286
PRO A 288
 None
 0.69A 5e72A-1wxxA:
17.4		 5e72A-1wxxA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 7 ASN A 258
VAL A 234
ALA A 236
GLY A 221
 None
 0.83A 5fpdA-1wxxA:
undetectable		 5fpdA-1wxxA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		4 / 7 ASN A 258
VAL A 234
ALA A 236
GLY A 221
 None
 0.85A 5fpdB-1wxxA:
undetectable		 5fpdB-1wxxA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 ALA A 266
ASP A 286
PRO A 288
PHE A 217
SER A 239
 None
 0.82A 5hfjF-1wxxA:
4.8		 5hfjF-1wxxA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1wxx HYPOTHETICAL PROTEIN
TTHA1280
(Thermus
thermophilus) 		5 / 12 HIS A  52
THR A  53
GLU A 156
GLY A 157
HIS A 124
 PO4  A1500 (-3.9A)
None
None
None
None
 1.36A 5utuH-1wxxA:
2.8		 5utuH-1wxxA:
21.02