SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wy0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 322
ILE A 191
GLY A 190
ASN A 196
ALA A 202
 None
 1.04A 1nv8A-1wy0A:
undetectable		 1nv8A-1wy0A:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 11 SER A  82
LEU A  83
ASP A  90
ARG A  95
LYS A 177
THR A 178
 None
 0.79A 1rqjA-1wy0A:
34.6		 1rqjA-1wy0A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 11 SER A  82
LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.72A 1rqjA-1wy0A:
34.6		 1rqjA-1wy0A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 11 SER A  82
LEU A  83
ASP A  90
ARG A  95
LYS A 177
THR A 178
 None
 0.79A 1rqjB-1wy0A:
34.4		 1rqjB-1wy0A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 11 SER A  82
LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.69A 1rqjB-1wy0A:
34.4		 1rqjB-1wy0A:
31.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 318
LYS A 335
LEU A 332
GLU A 339
ALA A 334
 None
 1.45A 1sn0A-1wy0A:
undetectable
1sn0C-1wy0A:
undetectable		 1sn0A-1wy0A:
17.87
1sn0C-1wy0A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.62A 1yhlA-1wy0A:
29.1		 1yhlA-1wy0A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A  83
ASP A  90
ARG A  95
GLN A 153
THR A 178
 None
 0.80A 1yq7A-1wy0A:
28.3		 1yq7A-1wy0A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.67A 1yq7A-1wy0A:
28.3		 1yq7A-1wy0A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
LYS A 177
THR A 178
 None
 0.87A 1yv5A-1wy0A:
28.5		 1yv5A-1wy0A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.65A 1yv5A-1wy0A:
28.5		 1yv5A-1wy0A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 GLU A 331
ASP A 329
PHE A  52
ARG A  10
 None
 1.33A 2a3bB-1wy0A:
undetectable		 2a3bB-1wy0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 SER A  82
LEU A 181
GLY A 179
ILE A 337
 None
 0.93A 2bdmA-1wy0A:
undetectable		 2bdmA-1wy0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.68A 2f8cF-1wy0A:
29.1		 2f8cF-1wy0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
GLN A 153
THR A 178
 None
 0.83A 2f8zF-1wy0A:
29.4		 2f8zF-1wy0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.71A 2f8zF-1wy0A:
29.4		 2f8zF-1wy0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 LEU A  83
ASP A  90
ARG A  95
GLN A 153
THR A 178
GLN A 215
 None
 0.64A 2f94F-1wy0A:
28.8		 2f94F-1wy0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.71A 2f9kF-1wy0A:
28.9		 2f9kF-1wy0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 174
ILE A 216
ALA A 307
ALA A 314
GLU A 183
 None
 1.19A 2j0dA-1wy0A:
undetectable		 2j0dA-1wy0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 ALA A 184
GLY A 189
ILE A 191
PRO A  71
ALA A  74
ILE A  75
 None
 1.46A 2nmzB-1wy0A:
undetectable		 2nmzB-1wy0A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.59A 2o1oA-1wy0A:
27.3		 2o1oA-1wy0A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.69A 2o1oB-1wy0A:
28.3		 2o1oB-1wy0A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A  90
ARG A  95
THR A 178
GLN A 215
ASP A 219
 None
 0.92A 2q58A-1wy0A:
27.7		 2q58A-1wy0A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.78A 2q58A-1wy0A:
27.7		 2q58A-1wy0A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
LYS A 177
THR A 178
 None
 0.87A 3ez3D-1wy0A:
28.4		 3ez3D-1wy0A:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.72A 3ez3D-1wy0A:
28.4		 3ez3D-1wy0A:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.68A 3n45F-1wy0A:
29.0		 3n45F-1wy0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.72A 3n46F-1wy0A:
28.8		 3n46F-1wy0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 221
ASP A 218
ILE A 174
GLY A 211
VAL A 210
 None
 1.05A 3oxwB-1wy0A:
undetectable		 3oxwB-1wy0A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 246
THR A 244
PHE A 266
ASP A 255
 None
 1.09A 4iarA-1wy0A:
4.0		 4iarA-1wy0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 142
ALA A  74
VAL A 188
VAL A  53
 None
 0.62A 4jltA-1wy0A:
1.5		 4jltA-1wy0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.67A 4kpdA-1wy0A:
29.3		 4kpdA-1wy0A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.65A 4kpjA-1wy0A:
29.0		 4kpjA-1wy0A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.69A 4kq5A-1wy0A:
29.0		 4kq5A-1wy0A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.63A 4kqsA-1wy0A:
29.6		 4kqsA-1wy0A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.64A 4n9uA-1wy0A:
28.8		 4n9uA-1wy0A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 LEU A  83
ASP A  90
ARG A  95
GLN A 153
THR A 178
GLN A 215
 None
 0.69A 4ng6A-1wy0A:
29.1		 4ng6A-1wy0A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.64A 4nkeA-1wy0A:
29.0		 4nkeA-1wy0A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.55A 4nkfA-1wy0A:
28.8		 4nkfA-1wy0A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.63A 4nuaA-1wy0A:
29.0		 4nuaA-1wy0A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.66A 4oguA-1wy0A:
28.4		 4oguA-1wy0A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.70A 4p0wA-1wy0A:
29.1		 4p0wA-1wy0A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
LYS A 177
THR A 178
 None
 0.84A 4rxdA-1wy0A:
28.6		 4rxdA-1wy0A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.65A 4rxdA-1wy0A:
28.6		 4rxdA-1wy0A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
LYS A 177
THR A 178
 None
 0.84A 4rxdB-1wy0A:
28.9		 4rxdB-1wy0A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.64A 4rxdB-1wy0A:
28.9		 4rxdB-1wy0A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
LYS A 177
THR A 178
 None
 0.83A 4rxdC-1wy0A:
29.0		 4rxdC-1wy0A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.66A 4rxdC-1wy0A:
29.0		 4rxdC-1wy0A:
26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 8 SER A  82
LEU A  83
ARG A  95
GLN A 153
LYS A 177
 None
 0.80A 4umjA-1wy0A:
33.4		 4umjA-1wy0A:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 8 SER A  82
LEU A  83
ASP A  86
GLN A 153
LYS A 177
 None
 1.27A 4umjA-1wy0A:
33.4		 4umjA-1wy0A:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 8 SER A  82
LEU A  83
ASP A  90
ARG A  95
GLN A 153
 None
 0.38A 4umjA-1wy0A:
33.4		 4umjA-1wy0A:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 9 SER A  82
LEU A  83
ARG A  95
GLN A 153
LYS A 177
THR A 178
 None
 0.80A 4umjB-1wy0A:
33.6		 4umjB-1wy0A:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 9 SER A  82
LEU A  83
ASP A  86
GLN A 153
LYS A 177
THR A 178
 None
 1.21A 4umjB-1wy0A:
33.6		 4umjB-1wy0A:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 9 SER A  82
LEU A  83
ASP A  90
ARG A  95
GLN A 153
THR A 178
 None
 0.53A 4umjB-1wy0A:
33.6		 4umjB-1wy0A:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 200
LEU A 203
GLY A 189
GLY A 190
 None
 0.67A 5a06A-1wy0A:
undetectable		 5a06A-1wy0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 200
LEU A 203
GLY A 189
GLY A 190
 None
 0.67A 5a06B-1wy0A:
undetectable		 5a06B-1wy0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 200
LEU A 203
GLY A 189
GLY A 190
 None
 0.68A 5a06C-1wy0A:
undetectable		 5a06C-1wy0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 200
LEU A 203
GLY A 189
GLY A 190
 None
 0.68A 5a06E-1wy0A:
undetectable		 5a06E-1wy0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 200
LEU A 203
GLY A 189
GLY A 190
 None
 0.70A 5a06F-1wy0A:
undetectable		 5a06F-1wy0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.64A 5cg5A-1wy0A:
28.1		 5cg5A-1wy0A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.64A 5cg6A-1wy0A:
28.8		 5cg6A-1wy0A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 127
LYS A 120
GLU A 123
 None
 0.69A 5d0yA-1wy0A:
2.7		 5d0yA-1wy0A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 218
LEU A  83
ARG A  95
 None
 0.71A 5e8qA-1wy0A:
undetectable		 5e8qA-1wy0A:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A  87
ASP A  90
ARG A  95
GLN A 215
LYS A 242
 None
 0.90A 5eroC-1wy0A:
26.1		 5eroC-1wy0A:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 192
GLY A 193
THR A 194
ASP A 195
VAL A 141
 None
 1.22A 5hw4A-1wy0A:
undetectable		 5hw4A-1wy0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 192
GLY A 193
THR A 194
ASP A 195
VAL A 141
 None
 1.18A 5hw4C-1wy0A:
undetectable		 5hw4C-1wy0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A 193
GLY A 189
SER A  57
LEU A 321
TYR A 199
 None
 1.11A 5hwkA-1wy0A:
undetectable		 5hwkA-1wy0A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A 193
GLY A 189
SER A  57
LEU A 321
TYR A 199
 None
 1.12A 5hwkB-1wy0A:
undetectable		 5hwkB-1wy0A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 ILE A 192
GLY A 193
GLY A  62
LEU A  55
ALA A  68
 None
 1.00A 5o96A-1wy0A:
undetectable
5o96B-1wy0A:
undetectable		 5o96A-1wy0A:
23.92
5o96B-1wy0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A 192
GLY A 193
GLY A  62
LEU A  55
ALA A  68
 None
 1.03A 5o96C-1wy0A:
undetectable
5o96D-1wy0A:
undetectable		 5o96C-1wy0A:
23.92
5o96D-1wy0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 337
PHE A 182
LEU A 181
LEU A  55
LEU A 333
 None
 1.12A 5xxiA-1wy0A:
undetectable		 5xxiA-1wy0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 ALA A 184
VAL A  53
SER A 185
SER A  57
GLY A 190
 None
 1.13A 6bklA-1wy0A:
undetectable
6bklB-1wy0A:
undetectable
6bklC-1wy0A:
undetectable
6bklD-1wy0A:
undetectable		 6bklA-1wy0A:
6.14
6bklB-1wy0A:
6.14
6bklC-1wy0A:
6.14
6bklD-1wy0A:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 VAL A 101
HIS A 102
ILE A  78
LEU A  77
ASP A 115
 None
 1.15A 6c2mC-1wy0A:
undetectable		 6c2mC-1wy0A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ASP A  90
ARG A  95
GLN A 153
LYS A 242
 None
 0.84A 6g31A-1wy0A:
26.8		 6g31A-1wy0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ASP A  90
ARG A  95
GLN A 215
LYS A 242
 None
 0.84A 6g31A-1wy0A:
26.8		 6g31A-1wy0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A  83
ASP A  90
ARG A  95
GLN A 153
 None
 0.67A 6g31D-1wy0A:
26.7		 6g31D-1wy0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A  83
ASP A  90
ARG A  95
GLN A 215
 None
 0.61A 6g31D-1wy0A:
26.7		 6g31D-1wy0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A  83
ASP A  90
ARG A  95
GLN A 153
 None
 0.81A 6g31J-1wy0A:
26.9		 6g31J-1wy0A:
14.37