SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wy1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 1wy1 HYPOTHETICAL PROTEIN
PH0671
(Pyrococcus
horikoshii) 		5 / 11 LEU A  56
GLY A  89
ILE A  91
ILE A  59
ILE A  55
 None
 1.08A 3ebzA-1wy1A:
undetectable		 3ebzA-1wy1A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1wy1 HYPOTHETICAL PROTEIN
PH0671
(Pyrococcus
horikoshii) 		4 / 7 LEU A 146
ALA A 130
GLY A 137
ILE A 138
 None
 0.86A 3spkB-1wy1A:
undetectable		 3spkB-1wy1A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1wy1 HYPOTHETICAL PROTEIN
PH0671
(Pyrococcus
horikoshii) 		5 / 12 ILE A  41
LEU A  87
ARG A 123
ILE A  66
LEU A  34
 None
 1.08A 4m6kA-1wy1A:
undetectable		 4m6kA-1wy1A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 1wy1 HYPOTHETICAL PROTEIN
PH0671
(Pyrococcus
horikoshii) 		4 / 5 LEU A 146
ALA A  30
ASN A  31
ILE A  70
 None
 0.90A 4y03B-1wy1A:
undetectable		 4y03B-1wy1A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 1wy1 HYPOTHETICAL PROTEIN
PH0671
(Pyrococcus
horikoshii) 		4 / 7 ARG A 134
GLY A 137
GLY A 139
GLU A 141
 None
 0.91A 4z53A-1wy1A:
undetectable
4z53B-1wy1A:
undetectable		 4z53A-1wy1A:
13.80
4z53B-1wy1A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1wy1 HYPOTHETICAL PROTEIN
PH0671
(Pyrococcus
horikoshii) 		4 / 7 ASN A  31
ILE A  27
PHE A 136
ILE A  76
 None
 0.70A 5bmvC-1wy1A:
undetectable		 5bmvC-1wy1A:
17.77