SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wy2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A  80
GLU A  86
LEU A  46
 None
 0.58A 1v8bA-1wy2A:
undetectable		 1v8bA-1wy2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A  80
GLU A  86
LEU A  46
 None
 0.59A 1v8bB-1wy2A:
undetectable		 1v8bB-1wy2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 11 VAL A 167
ILE A 151
THR A 346
ILE A 224
LEU A 213
 None
 1.05A 1z11A-1wy2A:
undetectable		 1z11A-1wy2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 10 VAL A 167
ILE A 151
THR A 346
ILE A 224
LEU A 213
 None
 1.04A 1z11C-1wy2A:
undetectable		 1z11C-1wy2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 10 VAL A 167
ILE A 151
THR A 346
ILE A 224
LEU A 213
 None
 1.05A 1z11D-1wy2A:
undetectable		 1z11D-1wy2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 350
ASP A 207
VAL A 209
ILE A 203
ILE A 228
 None
 0.98A 2idwA-1wy2A:
undetectable		 2idwA-1wy2A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A  82
PHE A 101
LEU A  46
LEU A  24
 None
 0.88A 2w98B-1wy2A:
undetectable		 2w98B-1wy2A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 8 MET A  15
LEU A  85
ILE A 111
THR A  48
LEU A  46
 None
 1.47A 2xfhA-1wy2A:
undetectable		 2xfhA-1wy2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 213
ALA A 180
ILE A 142
ALA A 146
ASP A 212
 None
None
None
None
ZN  A 405 ( 2.0A)
 1.20A 3axtA-1wy2A:
undetectable		 3axtA-1wy2A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 4 ILE A 224
GLN A 248
ILE A 211
LEU A 285
 None
 1.14A 3dzyD-1wy2A:
0.0		 3dzyD-1wy2A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A 231
ASP A 207
VAL A 209
ILE A 203
ILE A 228
 None
 0.86A 3ekpD-1wy2A:
undetectable		 3ekpD-1wy2A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 185
ALA A 150
ILE A 228
VAL A 209
VAL A 230
 None
 0.93A 3kw4A-1wy2A:
undetectable		 3kw4A-1wy2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 350
ASP A 207
VAL A 209
ILE A 203
ILE A 228
 None
 1.10A 3mwsB-1wy2A:
undetectable		 3mwsB-1wy2A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A 326
ILE A 243
VAL A 244
 None
 0.44A 3nv6A-1wy2A:
undetectable		 3nv6A-1wy2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 350
ASP A 207
VAL A 209
ILE A 203
ILE A 228
 None
 1.05A 3oxwB-1wy2A:
undetectable		 3oxwB-1wy2A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A 285
GLY A 286
PHE A 281
ARG A 269
 None
 1.21A 3smtA-1wy2A:
undetectable		 3smtA-1wy2A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 8 ALA A 180
PHE A 181
ALA A 143
THR A 344
 None
CAC  A 403 (-3.7A)
None
None
 0.91A 3t3sD-1wy2A:
undetectable		 3t3sD-1wy2A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 297
ILE A 315
LEU A 285
ALA A 268
ILE A 335
 None
 0.98A 3vrmA-1wy2A:
undetectable		 3vrmA-1wy2A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 11 THR A  48
ALA A  22
LEU A  91
SER A  51
ILE A  70
 None
 1.42A 4claA-1wy2A:
undetectable		 4claA-1wy2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 4 VAL A 117
VAL A 120
ASN A  30
ILE A  25
 None
None
GOL  A1401 (-3.2A)
None
 1.37A 4cutA-1wy2A:
undetectable		 4cutA-1wy2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A 101
ALA A 109
LEU A  46
LEU A  24
 None
 0.88A 4ejgB-1wy2A:
undetectable		 4ejgB-1wy2A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 7 PHE A 101
ALA A 109
LEU A  46
LEU A  24
 None
 0.86A 4ejgC-1wy2A:
undetectable		 4ejgC-1wy2A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 203
ILE A 185
ALA A 150
GLU A 152
 None
 0.77A 4jltA-1wy2A:
undetectable		 4jltA-1wy2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 265
VAL A 252
ASN A 270
 None
 0.79A 4lmnA-1wy2A:
undetectable		 4lmnA-1wy2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 313
VAL A 299
GLN A 248
GLU A 330
 None
None
None
ZN  A 405 (-2.3A)
 1.11A 5dqyA-1wy2A:
undetectable		 5dqyA-1wy2A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 265
ARG A 269
ILE A 313
ILE A 259
ILE A 272
 None
 1.15A 5hw8A-1wy2A:
undetectable
5hw8D-1wy2A:
undetectable		 5hw8A-1wy2A:
18.91
5hw8D-1wy2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		3 / 3 ILE A 321
PRO A 322
ILE A 324
 None
 0.35A 5hw8F-1wy2A:
undetectable		 5hw8F-1wy2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 286
HIS A 287
ASP A 223
HIS A 195
 None
ZN  A 406 (-3.3A)
ZN  A 405 (-2.3A)
CAC  A 403 ( 4.4A)
 0.70A 5nnwD-1wy2A:
undetectable		 5nnwD-1wy2A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 286
HIS A 287
ASP A 223
HIS A 195
 None
ZN  A 406 (-3.3A)
ZN  A 405 (-2.3A)
CAC  A 403 ( 4.4A)
 0.73A 5no9D-1wy2A:
undetectable		 5no9D-1wy2A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 327
TYR A 241
GLN A 237
 None
 0.62A 5qgkA-1wy2A:
undetectable		 5qgkA-1wy2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 327
TYR A 241
GLN A 237
 None
 0.61A 5qgrA-1wy2A:
undetectable		 5qgrA-1wy2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 327
TYR A 241
GLN A 237
 None
 0.56A 5qgtA-1wy2A:
undetectable		 5qgtA-1wy2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A  73
VAL A  72
SER A  68
PRO A  39
GLY A  42
 None
 1.27A 5syeB-1wy2A:
undetectable		 5syeB-1wy2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 6 ALA A  26
PRO A  39
VAL A  31
TYR A  44
 None
 1.18A 5umd2-1wy2A:
undetectable
5umdF-1wy2A:
undetectable		 5umd2-1wy2A:
16.23
5umdF-1wy2A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 5 TYR A  44
TYR A  55
GLY A  43
GLY A  42
 None
 1.17A 5x7pA-1wy2A:
undetectable		 5x7pA-1wy2A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 316
LEU A 285
ARG A 269
 ZN  A 406 ( 2.5A)
None
None
 0.69A 6d8fA-1wy2A:
undetectable		 6d8fA-1wy2A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1wy2 XAA-PRO DIPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 9 ILE A 154
ILE A 151
GLU A 204
VAL A 209
ILE A 228
 None
 1.25A 6hloA-1wy2A:
undetectable		 6hloA-1wy2A:
21.62