SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wy7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 GLN A  27
GLY A  57
GLY A  59
GLU A  79
ASP A 105
 SAH  A1001 (-3.8A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
 0.92A 1jg2A-1wy7A:
10.9		 1jg2A-1wy7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 11 GLN A  27
GLY A  57
GLY A  59
GLU A  79
ASP A 105
 SAH  A1001 (-3.8A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
 0.95A 1jg3A-1wy7A:
11.0		 1jg3A-1wy7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 11 GLN A  27
GLY A  57
GLY A  59
GLU A  79
ASP A 105
 SAH  A1001 (-3.8A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
 0.95A 1jg3B-1wy7A:
4.1		 1jg3B-1wy7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 GLY A  57
GLY A  59
VAL A  80
ASN A 119
PRO A 121
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-4.0A)
SAH  A1001 (-4.6A)
None
 0.66A 1nv8A-1wy7A:
15.1		 1nv8A-1wy7A:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 GLY A  57
GLY A  59
ASP A  81
ASP A 105
ASN A 119
PRO A 121
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
None
SAH  A1001 (-3.2A)
SAH  A1001 (-4.6A)
None
 0.59A 1qaoA-1wy7A:
15.2		 1qaoA-1wy7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		3 / 3 GLY A  57
GLU A  79
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-2.8A)
SAH  A1001 (-4.6A)
 0.69A 1zq9A-1wy7A:
15.3		 1zq9A-1wy7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 GLY A  57
GLY A  59
ASP A 105
VAL A 106
ASN A 119
PRO A 121
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.2A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.6A)
None
 1.06A 1zq9B-1wy7A:
14.8		 1zq9B-1wy7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 11 GLU A  79
ASP A  81
ALA A  84
ASP A 105
PRO A 121
PHE A 133
 SAH  A1001 (-2.8A)
None
SAH  A1001 ( 4.8A)
SAH  A1001 (-3.2A)
None
SAH  A1001 (-4.7A)
 0.73A 2admA-1wy7A:
6.8		 2admA-1wy7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 11 GLU A  79
ALA A  84
ASP A 105
PRO A 121
PHE A 133
 SAH  A1001 (-2.8A)
SAH  A1001 ( 4.8A)
SAH  A1001 (-3.2A)
None
SAH  A1001 (-4.7A)
 0.82A 2admB-1wy7A:
6.9		 2admB-1wy7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 THR A  30
GLY A  57
GLY A  59
VAL A  80
ASP A 105
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-4.0A)
SAH  A1001 (-3.2A)
 0.64A 2b25A-1wy7A:
16.5		 2b25A-1wy7A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 GLY A  59
LEU A  63
VAL A  80
ASP A  81
PRO A 121
PHE A 133
 SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-4.0A)
None
None
SAH  A1001 (-4.7A)
 0.91A 2f8lA-1wy7A:
17.2		 2f8lA-1wy7A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 ASP A  55
GLY A  57
GLY A  59
LEU A  63
ASP A  81
ASN A 119
 SAH  A1001 ( 4.5A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
None
SAH  A1001 (-4.6A)
 0.47A 2nxeA-1wy7A:
16.4		 2nxeA-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 ASP A  55
LEU A  56
GLY A  57
GLY A  59
LEU A  63
ASN A 119
 SAH  A1001 ( 4.5A)
None
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-4.6A)
 0.77A 2nxeA-1wy7A:
16.4		 2nxeA-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 ASP A  55
GLY A  57
GLY A  59
LEU A  63
ASP A  81
ASN A 119
 SAH  A1001 ( 4.5A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
None
SAH  A1001 (-4.6A)
 0.48A 2nxeB-1wy7A:
16.6		 2nxeB-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 ASP A  55
LEU A  56
GLY A  57
GLY A  59
LEU A  63
ASN A 119
 SAH  A1001 ( 4.5A)
None
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-4.6A)
 0.74A 2nxeB-1wy7A:
16.6		 2nxeB-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		3 / 3 ASP A 130
THR A  30
PRO A  31
 None
SAH  A1001 (-4.0A)
None
 0.59A 2pynB-1wy7A:
undetectable		 2pynB-1wy7A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		3 / 3 ASP A 130
THR A  30
PRO A  31
 None
SAH  A1001 (-4.0A)
None
 0.58A 2q64B-1wy7A:
undetectable		 2q64B-1wy7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		3 / 3 ASP A 130
THR A  30
PRO A  31
 None
SAH  A1001 (-4.0A)
None
 0.61A 2qakB-1wy7A:
undetectable		 2qakB-1wy7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 THR A  30
GLY A  59
THR A  60
GLY A  61
ASN A 119
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.1A)
SAH  A1001 (-4.6A)
SAH  A1001 (-4.7A)
 1.03A 2y7hB-1wy7A:
11.8		 2y7hB-1wy7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 THR A  30
THR A  60
GLY A  61
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.1A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 1.12A 2y7hB-1wy7A:
11.8		 2y7hB-1wy7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 THR A  30
GLY A  59
THR A  60
GLY A  61
ASN A 119
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.1A)
SAH  A1001 (-4.6A)
SAH  A1001 (-4.7A)
 1.03A 2y7hC-1wy7A:
13.0		 2y7hC-1wy7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 THR A  30
THR A  60
GLY A  61
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.1A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 1.13A 2y7hC-1wy7A:
13.0		 2y7hC-1wy7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 GLY A  57
GLY A  59
LEU A  63
ASP A  81
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
None
SAH  A1001 (-4.6A)
 0.49A 2zbpA-1wy7A:
16.5		 2zbpA-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 LEU A  56
GLY A  57
GLY A  59
LEU A  63
ASN A 119
 None
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-4.6A)
 0.86A 2zbpA-1wy7A:
16.5		 2zbpA-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		7 / 12 GLY A  57
GLY A  59
LEU A  63
VAL A 106
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 0.61A 2zulA-1wy7A:
14.0		 2zulA-1wy7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 ASP A  55
GLY A  57
VAL A  62
LEU A  63
ASP A  81
 SAH  A1001 ( 4.5A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.4A)
SAH  A1001 ( 4.3A)
None
 0.47A 3cjtC-1wy7A:
16.6		 3cjtC-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 ASP A  55
LEU A  56
GLY A  57
VAL A  62
LEU A  63
 SAH  A1001 ( 4.5A)
None
SAH  A1001 (-3.4A)
SAH  A1001 (-3.4A)
SAH  A1001 ( 4.3A)
 0.75A 3cjtC-1wy7A:
16.6		 3cjtC-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 GLY A  57
GLY A  59
VAL A  62
LEU A  63
ASP A  81
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.4A)
SAH  A1001 ( 4.3A)
None
SAH  A1001 (-4.6A)
 0.52A 3cjtG-1wy7A:
16.5		 3cjtG-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 LEU A  56
GLY A  57
GLY A  59
VAL A  62
LEU A  63
ASN A 119
 None
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.4A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-4.6A)
 0.74A 3cjtG-1wy7A:
16.5		 3cjtG-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 GLY A  57
GLY A  59
VAL A  62
LEU A  63
ASP A  81
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.4A)
SAH  A1001 ( 4.3A)
None
SAH  A1001 (-4.6A)
 0.54A 3cjtO-1wy7A:
16.6		 3cjtO-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 LEU A  56
GLY A  57
GLY A  59
VAL A  62
LEU A  63
ASN A 119
 None
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.4A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-4.6A)
 0.74A 3cjtO-1wy7A:
16.6		 3cjtO-1wy7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		7 / 12 GLY A  57
GLY A  59
ASP A 105
VAL A 106
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.2A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 0.69A 3dmfA-1wy7A:
13.9		 3dmfA-1wy7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		7 / 12 GLY A  57
GLY A  59
LEU A  63
VAL A 106
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 0.61A 3dmhA-1wy7A:
14.0		 3dmhA-1wy7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 11 GLY A  57
GLY A  59
GLU A  79
VAL A  80
ASP A 105
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-2.8A)
SAH  A1001 (-4.0A)
SAH  A1001 (-3.2A)
 0.58A 3dxyA-1wy7A:
11.0		 3dxyA-1wy7A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 GLN A  27
GLY A  57
GLY A  59
GLU A  79
ASP A  81
ASP A 105
 SAH  A1001 (-3.8A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-2.8A)
None
SAH  A1001 (-3.2A)
 0.48A 3fuuA-1wy7A:
16.8		 3fuuA-1wy7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 GLN A  27
GLY A  59
ASP A  81
ASP A 105
PRO A 121
 SAH  A1001 (-3.8A)
SAH  A1001 (-3.3A)
None
SAH  A1001 (-3.2A)
None
 0.86A 3fuuA-1wy7A:
16.8		 3fuuA-1wy7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 11 GLY A  57
GLU A  79
ASP A  81
ASP A 105
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-2.8A)
None
SAH  A1001 (-3.2A)
SAH  A1001 (-4.6A)
 0.58A 3grvA-1wy7A:
16.9		 3grvA-1wy7A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 11 GLY A  57
GLY A  59
ASP A  81
ASP A 105
ASN A 119
PRO A 121
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
None
SAH  A1001 (-3.2A)
SAH  A1001 (-4.6A)
None
 1.07A 3grvA-1wy7A:
16.9		 3grvA-1wy7A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 GLY A  57
GLU A  79
ASP A  81
ASP A 105
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-2.8A)
None
SAH  A1001 (-3.2A)
SAH  A1001 (-4.6A)
 0.50A 3gryA-1wy7A:
16.8		 3gryA-1wy7A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 12 GLY A  57
GLY A  59
ASP A  81
ASP A 105
ASN A 119
PRO A 121
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
None
SAH  A1001 (-3.2A)
SAH  A1001 (-4.6A)
None
 1.07A 3gryA-1wy7A:
16.8		 3gryA-1wy7A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		4 / 6 GLY A  59
THR A  60
GLU A  79
ASP A  55
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
SAH  A1001 (-2.8A)
SAH  A1001 ( 4.5A)
 0.89A 3ps9A-1wy7A:
10.4		 3ps9A-1wy7A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		3 / 3 THR A  30
ASP A  55
GLU A  79
 SAH  A1001 (-4.0A)
SAH  A1001 ( 4.5A)
SAH  A1001 (-2.8A)
 0.81A 3qowA-1wy7A:
9.0		 3qowA-1wy7A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 GLY A  57
GLY A  59
THR A  60
ASP A 105
VAL A 106
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
SAH  A1001 (-3.2A)
SAH  A1001 (-3.9A)
 0.44A 3sglA-1wy7A:
3.2		 3sglA-1wy7A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		3 / 3 ASP A 130
THR A  30
PRO A  31
 None
SAH  A1001 (-4.0A)
None
 0.53A 3tkgD-1wy7A:
undetectable		 3tkgD-1wy7A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 GLY A  59
ASP A  81
VAL A 106
ASN A 119
PRO A 121
 SAH  A1001 (-3.3A)
None
SAH  A1001 (-3.9A)
SAH  A1001 (-4.6A)
None
 0.44A 3v8vA-1wy7A:
15.6		 3v8vA-1wy7A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		6 / 11 GLY A  59
ASP A  81
ASP A 105
VAL A 106
ASN A 119
PRO A 121
 SAH  A1001 (-3.3A)
None
SAH  A1001 (-3.2A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.6A)
None
 0.73A 3v8vB-1wy7A:
10.9		 3v8vB-1wy7A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		4 / 6 GLY A  59
GLU A  79
ASP A 105
ASP A  55
 SAH  A1001 (-3.3A)
SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
SAH  A1001 ( 4.5A)
 0.95A 3vywC-1wy7A:
10.6		 3vywC-1wy7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 11 ASP A  55
GLY A  57
GLY A  59
ASN A 119
PRO A 121
 SAH  A1001 ( 4.5A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-4.6A)
None
 0.48A 4dcmA-1wy7A:
16.9		 4dcmA-1wy7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 GLY A  57
GLY A  59
VAL A 106
ASN A 119
PRO A 121
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.6A)
None
 0.78A 4gc9A-1wy7A:
13.1		 4gc9A-1wy7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		3 / 3 GLU A  79
ASP A  81
ASP A 105
 SAH  A1001 (-2.8A)
None
SAH  A1001 (-3.2A)
 0.39A 4gc9A-1wy7A:
13.1		 4gc9A-1wy7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		4 / 7 ASN A  33
ALA A  34
SER A  36
VAL A  62
 None
None
None
SAH  A1001 (-3.4A)
 1.12A 4ijiH-1wy7A:
undetectable		 4ijiH-1wy7A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 10 ILE A 117
ALA A  54
ASP A  55
VAL A 101
LEU A  92
 None
None
SAH  A1001 ( 4.5A)
None
None
 1.36A 4kq8A-1wy7A:
0.0		 4kq8A-1wy7A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		4 / 7 ALA A  84
PHE A  18
LYS A  22
TYR A  28
 SAH  A1001 ( 4.8A)
SAH  A1001 (-4.3A)
None
None
 0.94A 4lb2A-1wy7A:
undetectable		 4lb2A-1wy7A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 8 ALA A  84
PHE A  18
GLY A  59
ALA A  58
GLY A  61
 SAH  A1001 ( 4.8A)
SAH  A1001 (-4.3A)
SAH  A1001 (-3.3A)
None
SAH  A1001 (-4.1A)
 1.31A 4zjzB-1wy7A:
2.5		 4zjzB-1wy7A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		4 / 7 GLY A  57
GLY A  59
GLU A  79
ASP A 105
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
 0.56A 5ergB-1wy7A:
14.5		 5ergB-1wy7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		3 / 3 THR A  30
ASP A  55
GLU A  79
 SAH  A1001 (-4.0A)
SAH  A1001 ( 4.5A)
SAH  A1001 (-2.8A)
 0.65A 5fa8A-1wy7A:
16.4		 5fa8A-1wy7A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 11 GLY A  59
GLU A  79
ASP A 105
VAL A 106
PRO A 121
 SAH  A1001 (-3.3A)
SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
SAH  A1001 (-3.9A)
None
 0.61A 5hjiA-1wy7A:
16.2		 5hjiA-1wy7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		4 / 7 GLY A  57
GLU A  79
ASP A 105
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
SAH  A1001 (-4.6A)
 0.39A 5mvsA-1wy7A:
8.1		 5mvsA-1wy7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		4 / 8 GLY A  57
GLU A  79
ASP A 105
ASN A 119
 SAH  A1001 (-3.4A)
SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
SAH  A1001 (-4.6A)
 0.35A 5mvsB-1wy7A:
11.9		 5mvsB-1wy7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 GLY A  59
THR A  60
GLY A  61
ASN A 119
PHE A 133
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.1A)
SAH  A1001 (-4.6A)
SAH  A1001 (-4.7A)
 0.95A 5ybbA-1wy7A:
13.8		 5ybbA-1wy7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 THR A  30
ASP A  55
THR A  60
ASN A 119
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 ( 4.5A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.6A)
SAH  A1001 (-4.7A)
 0.77A 5ybbB-1wy7A:
13.8		 5ybbB-1wy7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 12 THR A  30
THR A  60
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 0.71A 5ybbB-1wy7A:
13.8		 5ybbB-1wy7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		4 / 5 GLN A  27
GLU A  79
ASP A 105
ASN A 119
 SAH  A1001 (-3.8A)
SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
SAH  A1001 (-4.6A)
 0.45A 6iftA-1wy7A:
15.7		 6iftA-1wy7A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1wy7 HYPOTHETICAL PROTEIN
PH1948
(Pyrococcus
horikoshii) 		5 / 10 THR A  30
ASP A  55
GLY A  57
GLY A  59
ASN A 119
 SAH  A1001 (-4.0A)
SAH  A1001 ( 4.5A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-4.6A)
 0.71A 6nqaK-1wy7A:
10.8		 6nqaK-1wy7A:
21.57