SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wyd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  28
LYS A  97
VAL A  71
ALA A  89
ILE A  92
 None
 1.01A 1epbA-1wydA:
undetectable		 1epbA-1wydA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  28
LYS A  97
VAL A  71
ALA A  89
ILE A  92
 None
 0.96A 1epbB-1wydA:
undetectable		 1epbB-1wydA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		5 / 11 SER A  67
ALA A  22
VAL A  48
LEU A  87
ALA A  89
 None
 1.08A 1jinA-1wydA:
undetectable		 1jinA-1wydA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A 294
GLY A 297
ILE A 284
GLU A 285
 None
 0.83A 1mrjA-1wydA:
undetectable		 1mrjA-1wydA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 242
ILE A 245
ILE A 249
LEU A 404
LEU A 401
 None
 0.80A 2bdmA-1wydA:
undetectable		 2bdmA-1wydA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 117
ARG A 127
ARG A 121
 None
 0.93A 2jb7A-1wydA:
undetectable
2jb7B-1wydA:
undetectable
2jb7C-1wydA:
undetectable		 2jb7A-1wydA:
18.74
2jb7B-1wydA:
18.74
2jb7C-1wydA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 121
ARG A 117
ARG A 127
 None
 0.93A 2jb7A-1wydA:
undetectable
2jb7B-1wydA:
undetectable
2jb7C-1wydA:
undetectable		 2jb7A-1wydA:
18.74
2jb7B-1wydA:
18.74
2jb7C-1wydA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 127
ARG A 121
ARG A 117
 None
 0.96A 2jb7A-1wydA:
undetectable
2jb7B-1wydA:
undetectable
2jb7C-1wydA:
undetectable		 2jb7A-1wydA:
18.74
2jb7B-1wydA:
18.74
2jb7C-1wydA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		3 / 3 PHE A 329
PHE A 380
PHE A 382
 None
 0.77A 2od9A-1wydA:
undetectable		 2od9A-1wydA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		3 / 3 ILE A  38
ILE A   7
LEU A 102
 None
 0.51A 2prgA-1wydA:
undetectable		 2prgA-1wydA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		3 / 3 PHE A 329
PHE A 380
PHE A 382
 None
 0.77A 2qqgA-1wydA:
undetectable		 2qqgA-1wydA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		5 / 10 VAL A 250
GLY A 410
ILE A 411
ALA A 140
ILE A 253
 None
 0.97A 3ekpB-1wydA:
undetectable		 3ekpB-1wydA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		5 / 9 VAL A 250
GLY A 410
ILE A 411
ALA A 140
ILE A 253
 None
 1.01A 3ektB-1wydA:
undetectable		 3ektB-1wydA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 261
MET A 407
GLY A 410
PRO A 269
LEU A 316
 None
 0.93A 3tm4A-1wydA:
undetectable		 3tm4A-1wydA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 261
MET A 407
GLY A 410
PRO A 269
LEU A 316
 None
 0.93A 3tm4B-1wydA:
undetectable		 3tm4B-1wydA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A   7
ILE A  85
GLU A  18
VAL A  71
 None
 0.88A 3ua5A-1wydA:
undetectable		 3ua5A-1wydA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		4 / 8 MET A 130
LEU A 261
LEU A 264
ILE A 253
 None
 0.74A 4klaA-1wydA:
undetectable		 4klaA-1wydA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		4 / 6 THR A 147
ALA A 143
LEU A 139
SER A 138
 None
 1.04A 4pwjA-1wydA:
undetectable		 4pwjA-1wydA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		4 / 7 THR A 147
ALA A 143
LEU A 139
SER A 138
 None
 1.01A 4pwjB-1wydA:
undetectable		 4pwjB-1wydA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		4 / 7 GLU A 229
ARG A 327
GLY A 356
GLY A 396
 None
 0.60A 4rdxA-1wydA:
16.4		 4rdxA-1wydA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		4 / 7 THR A 147
ALA A 143
LEU A 139
SER A 138
 None
 1.03A 5bojB-1wydA:
undetectable		 5bojB-1wydA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A 164
ALA A 182
VAL A 175
 None
 0.55A 5xiwC-1wydA:
undetectable		 5xiwC-1wydA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE
(Sulfurisphaera
tokodaii) 		5 / 11 GLY A 398
GLY A 396
LEU A 242
VAL A 238
ASP A 345
 None
 1.21A 6i5zD-1wydA:
undetectable		 6i5zD-1wydA:
21.80