SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IV6_C_SAMC301_0 (PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE)	1wyo	MICROTUBULE-ASSOCIAT ED PROTEIN RP/EB FAMILY MEMBER 3 (Homo sapiens)	5 / 12	PHE A 70 GLY A 48 PHE A 118 ILE A 98 LEU A 85	None	1.25A	3iv6C-1wyoA: undetectable	3iv6C-1wyoA: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y4D_A_CFFA411_1 (ENDOTHIAPEPSIN)	1wyo	MICROTUBULE-ASSOCIAT ED PROTEIN RP/EB FAMILY MEMBER 3 (Homo sapiens)	4 / 6	LEU A 58 PHE A 122 ILE A 115 PHE A 118	None	1.13A	4y4dA-1wyoA: undetectable	4y4dA-1wyoA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIE_C_P06C801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1wyo	MICROTUBULE-ASSOCIAT ED PROTEIN RP/EB FAMILY MEMBER 3 (Homo sapiens)	4 / 7	ILE A 42 VAL A 68 ASN A 32 PHE A 70	None	0.71A	5hieC-1wyoA: undetectable	5hieC-1wyoA: 18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XXI_A_LSNA501_1 (CYTOCHROME P450 2C9)	1wyo	MICROTUBULE-ASSOCIAT ED PROTEIN RP/EB FAMILY MEMBER 3 (Homo sapiens)	5 / 12	VAL A 68 VAL A 100 GLY A 48 ALA A 49 LEU A 65	None	1.09A	5xxiA-1wyoA: undetectable	5xxiA-1wyoA: 15.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3IV6_C_SAMC301_0","PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE","1wyo","MICROTUBULE-ASSOCIATED PROTEIN RP\/EB FAMILY MEMBER 3","Homo sapiens",5,"PHE A  70;GLY A  48;PHE A 118;ILE A  98;LEU A  85","None","1.25A","3iv6C-1wyoA:undetectable","3iv6C-1wyoA:21.29"],["4Y4D_A_CFFA411_1","ENDOTHIAPEPSIN","1wyo","MICROTUBULE-ASSOCIATED PROTEIN RP\/EB FAMILY MEMBER 3","Homo sapiens",4,"LEU A  58;PHE A 122;ILE A 115;PHE A 118","None","1.13A","4y4dA-1wyoA:undetectable","4y4dA-1wyoA:21.58"],["5HIE_C_P06C801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","1wyo","MICROTUBULE-ASSOCIATED PROTEIN RP\/EB FAMILY MEMBER 3","Homo sapiens",4,"ILE A  42;VAL A  68;ASN A  32;PHE A  70","None","0.71A","5hieC-1wyoA:undetectable","5hieC-1wyoA:18.54"],["5XXI_A_LSNA501_1","CYTOCHROME P450 2C9","1wyo","MICROTUBULE-ASSOCIATED PROTEIN RP\/EB FAMILY MEMBER 3","Homo sapiens",5,"VAL A  68;VAL A 100;GLY A  48;ALA A  49;LEU A  65","None","1.09A","5xxiA-1wyoA:undetectable","5xxiA-1wyoA:15.03"]]