SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		4 / 8 ASN A 111
LEU A 107
LEU A  52
SER A  17
 None
 1.05A 1hk2A-1wyrA:
undetectable		 1hk2A-1wyrA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		5 / 12 PHE A 100
PHE A  89
SER A  38
LEU A  15
VAL A  44
 None
 1.32A 1q23C-1wyrA:
undetectable		 1q23C-1wyrA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		4 / 7 LEU A  39
PHE A  34
PHE A 100
LEU A 107
 None
 0.95A 1wrlE-1wyrA:
undetectable
1wrlF-1wyrA:
undetectable		 1wrlE-1wyrA:
19.66
1wrlF-1wyrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		5 / 10 PHE A 100
PHE A  89
SER A  38
LEU A  15
VAL A  44
 None
 1.29A 3u9fE-1wyrA:
undetectable		 3u9fE-1wyrA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		5 / 10 PHE A 100
PHE A  89
SER A  38
LEU A  15
VAL A  44
 None
 1.33A 3u9fR-1wyrA:
undetectable		 3u9fR-1wyrA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		4 / 8 LEU A  45
LEU A  48
LEU A  52
VAL A  86
 None
 0.87A 4klaA-1wyrA:
undetectable		 4klaA-1wyrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		4 / 5 THR A 114
THR A 106
LEU A  45
LEU A  48
 None
 1.04A 4lvcB-1wyrA:
undetectable		 4lvcB-1wyrA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		4 / 8 ILE A  28
LEU A 108
LEU A  15
PHE A  34
 None
 0.96A 4r38B-1wyrA:
undetectable		 4r38B-1wyrA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6
(Homo
sapiens) 		3 / 3 LEU A  52
GLY A  80
PHE A  89
 None
 0.66A 6exiC-1wyrA:
undetectable		 6exiC-1wyrA:
18.85