SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 5 THR B 403
GLU B 417
THR B 419
HIS B 272
 None
 1.32A 1d4fA-1wytB:
undetectable		 1d4fA-1wytB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 5 THR B 403
GLU B 417
THR B 419
HIS B 272
 None
 1.37A 1d4fB-1wytB:
1.6		 1d4fB-1wytB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 5 GLU B 420
THR A   4
HIS A   6
LEU B 427
 None
 1.36A 1d4fC-1wytB:
2.4		 1d4fC-1wytB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 5 THR B 403
GLU B 417
THR B 419
HIS B 272
 None
 1.28A 1d4fD-1wytB:
3.2		 1d4fD-1wytB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 12 ARG B 456
LEU B 414
LEU B 437
LEU B 445
ASP B 389
 None
 1.44A 1e7wA-1wytB:
2.1		 1e7wA-1wytB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 11 LEU A 235
PHE A 228
ALA A 248
ALA A 251
LEU A 120
 None
 1.36A 1hbpA-1wytA:
undetectable		 1hbpA-1wytA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 VAL A 153
LEU A 178
THR A 180
LEU A 181
 None
 0.93A 1jgsA-1wytA:
undetectable		 1jgsA-1wytA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 12 LEU A 235
PHE A 228
ALA A 248
ALA A 251
LEU A 120
 None
 1.17A 1kt5A-1wytA:
undetectable		 1kt5A-1wytA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 10 PHE A 415
LEU A 393
VAL A 389
VAL A 363
VAL A 366
 None
 1.33A 1o76A-1wytA:
undetectable		 1o76A-1wytA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 8 VAL B 191
GLU B 190
SER B 164
ILE B 183
 None
 0.80A 1pk7B-1wytB:
undetectable		 1pk7B-1wytB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 6 TYR A   3
HIS B  83
PRO A  42
VAL A  50
 None
 1.43A 1q13A-1wytA:
undetectable		 1q13A-1wytA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 8 TYR A  95
GLY B 278
GLY B 276
GLY B 275
 None
 0.62A 1qzzA-1wytA:
undetectable		 1qzzA-1wytA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 8 PHE A 415
LEU A 393
VAL A 389
VAL A 363
VAL A 366
 None
 1.33A 1t86A-1wytA:
undetectable		 1t86A-1wytA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 9 PHE A 415
LEU A 393
VAL A 389
VAL A 363
VAL A 366
 None
 1.31A 1t86B-1wytA:
0.0		 1t86B-1wytA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 5 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.09A 1t88B-1wytA:
0.0		 1t88B-1wytA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 5 PHE A 415
LEU A 393
VAL A 389
VAL A 366
 None
 1.22A 1t88B-1wytA:
0.0		 1t88B-1wytA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 11 GLY B  16
ALA A 336
ALA A 335
VAL A  81
VAL A  82
 None
 1.14A 1ukbA-1wytB:
undetectable		 1ukbA-1wytB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		3 / 3 LEU B 325
PHE B 324
ARG B 335
 None
 0.85A 1xdkB-1wytB:
undetectable		 1xdkB-1wytB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		3 / 3 LEU B 325
PHE B 324
ARG B 335
 None
 0.85A 1xdkF-1wytB:
undetectable		 1xdkF-1wytB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 5 ILE B 222
SER B 164
LEU B 209
ASN B 211
 None
 1.15A 1y0xX-1wytB:
undetectable		 1y0xX-1wytB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 5 LEU B 445
GLY B 398
PRO B 449
ALA B 448
 None
 0.85A 2aohA-1wytB:
undetectable		 2aohA-1wytB:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 8 ARG A 164
LEU A 167
VAL A 252
VAL A 159
 None
 0.97A 2bdmA-1wytA:
undetectable		 2bdmA-1wytA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.08A 2cppA-1wytA:
undetectable		 2cppA-1wytA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 378
VAL A 366
LEU A 382
ALA A 379
 None
 0.99A 2e1qA-1wytA:
undetectable		 2e1qA-1wytA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 378
VAL A 366
LEU A 382
ALA A 379
 None
 0.98A 2e1qC-1wytA:
undetectable		 2e1qC-1wytA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.02A 2feuA-1wytA:
0.0		 2feuA-1wytA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 PHE A 369
LEU A 208
PRO A 386
GLU A 410
 None
 1.04A 2jn3A-1wytA:
undetectable		 2jn3A-1wytA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 5 ALA A 432
ALA A 401
ALA A 413
VAL A 366
 None
 0.91A 2nyrB-1wytA:
2.2		 2nyrB-1wytA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 GLY A 298
GLY A 295
LEU A 107
GLU A 289
ASP B 458
 None
 0.84A 2oxtC-1wytA:
undetectable		 2oxtC-1wytA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 6 LEU B 112
LEU B 327
TRP B 331
ILE B 334
 None
 1.10A 2rlfB-1wytB:
undetectable
2rlfC-1wytB:
undetectable		 2rlfB-1wytB:
7.19
2rlfC-1wytB:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 6 LEU B 112
LEU B 327
TRP B 331
ILE B 334
 None
 1.00A 2rlfC-1wytB:
undetectable
2rlfD-1wytB:
undetectable		 2rlfC-1wytB:
7.19
2rlfD-1wytB:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 8 PRO B 449
THR B 452
PRO B 453
VAL B 454
 None
 0.83A 2v41C-1wytB:
undetectable
2v41D-1wytB:
undetectable		 2v41C-1wytB:
19.75
2v41D-1wytB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 7 TYR B 238
PHE B 257
PRO A  31
LEU B 223
 None
 1.17A 2vcvA-1wytB:
undetectable		 2vcvA-1wytB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 12 VAL B 270
ILE B 334
LEU B 116
LEU B 108
THR B 267
 None
 1.13A 2w3vA-1wytB:
undetectable		 2w3vA-1wytB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 12 HIS B  94
LEU A 414
VAL A 404
PHE B 320
PHE A 207
 None
 1.21A 2weyA-1wytB:
undetectable		 2weyA-1wytB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 7 PHE A 269
ALA A 327
ALA A 331
LEU B  42
 None
 0.79A 2wx2A-1wytA:
undetectable		 2wx2A-1wytA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 4 ARG A 343
GLY A 341
GLU A 340
SER A 257
 None
 1.36A 2xctS-1wytA:
undetectable
2xctU-1wytA:
undetectable		 2xctS-1wytA:
22.71
2xctU-1wytA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 8 LEU B 351
ILE A  11
LEU A  15
LEU A  26
 None
 0.68A 2xfhA-1wytB:
undetectable		 2xfhA-1wytB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 TYR B 321
GLU A 162
THR A 402
 None
 0.90A 2y7hB-1wytB:
undetectable		 2y7hB-1wytB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 12 ILE A 310
GLY A 284
SER A 129
ASN A 127
ILE A 319
 None
 1.27A 2ycjA-1wytA:
undetectable		 2ycjA-1wytA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.06A 2zaxA-1wytA:
undetectable		 2zaxA-1wytA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.07A 2zuiA-1wytA:
0.0		 2zuiA-1wytA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 12 PHE A 269
ARG B 329
ASN B 323
ARG B 318
LEU B 325
 None
 1.37A 3aobC-1wytA:
0.0		 3aobC-1wytA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		3 / 3 THR B 210
SER B  73
LYS B 266
 None
 1.17A 3aocC-1wytB:
2.1		 3aocC-1wytB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 8 PHE A 378
VAL A 366
LEU A 382
ALA A 379
 None
 1.01A 3ax7A-1wytA:
undetectable		 3ax7A-1wytA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 LYS A 348
LYS B  21
VAL B  20
 None
 0.84A 3brfA-1wytA:
undetectable		 3brfA-1wytA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 7 THR B 126
VAL B 282
ILE B 142
ILE B 314
SER B 313
 None
 1.29A 3deuA-1wytB:
undetectable		 3deuA-1wytB:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 12 LEU A 414
GLY A  70
PHE A 415
ALA A 417
LEU A 235
 None
 1.09A 3dh0B-1wytA:
2.5		 3dh0B-1wytA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 8 PRO B 381
PRO B  70
HIS B 400
GLY B 393
 None
 0.93A 3em0B-1wytB:
undetectable		 3em0B-1wytB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 6 SER B  58
TYR B  54
LEU B  57
ARG B  59
LEU A  85
 None
 1.40A 3f33A-1wytB:
undetectable		 3f33A-1wytB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 12 SER B 319
HIS A 268
VAL A 252
GLY A 253
VAL A 166
 None
 1.32A 3f8wB-1wytB:
undetectable		 3f8wB-1wytB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.04A 3fwfA-1wytA:
0.0		 3fwfA-1wytA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.03A 3fwfB-1wytA:
0.0		 3fwfB-1wytA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.06A 3fwgA-1wytA:
0.0		 3fwgA-1wytA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.03A 3fwjA-1wytA:
0.0		 3fwjA-1wytA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 10 PRO B  95
SER B 319
TYR A 163
GLY A  72
GLY A  71
 None
 1.27A 3ixlA-1wytB:
undetectable		 3ixlA-1wytB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 12 GLY A 253
ALA A 273
ALA A 230
VAL A 231
ASN A 204
 None
 1.04A 3jb3A-1wytA:
undetectable		 3jb3A-1wytA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 HIS A 160
VAL A 159
VAL A 166
ALA A 138
 None
 1.02A 3kp6B-1wytA:
undetectable		 3kp6B-1wytA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		6 / 12 GLY B 283
PRO B 252
GLY B 139
ALA B 124
LEU B 288
ILE B 142
 None
 1.43A 3ku1A-1wytB:
undetectable		 3ku1A-1wytB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 LEU B  50
GLY A 330
ALA A 335
LEU A 120
ILE A 117
 None
 0.99A 3ku1H-1wytB:
undetectable		 3ku1H-1wytB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 11 ALA A 346
GLY A 341
SER A 236
LEU A 235
LEU A 258
 None
 1.22A 3kw2A-1wytA:
undetectable		 3kw2A-1wytA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 11 ALA A 346
GLY A 341
SER A 236
LEU A 235
LEU A 258
 None
 1.21A 3kw2B-1wytA:
undetectable		 3kw2B-1wytA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 8 PHE A 269
ALA A 327
ALA A 331
LEU B  42
 None
 0.96A 3l4dA-1wytA:
undetectable		 3l4dA-1wytA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.02A 3l63A-1wytA:
0.0		 3l63A-1wytA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 11 LEU A 258
PHE A 269
TYR A 113
LEU A 120
ILE A 117
 None
 1.38A 3o94A-1wytA:
undetectable		 3o94A-1wytA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 11 LEU A 258
PHE A 269
TYR A 113
LEU A 120
ILE A 117
 None
 1.41A 3o94B-1wytA:
undetectable		 3o94B-1wytA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 11 LEU A 258
PHE A 269
TYR A 113
LEU A 120
ILE A 117
 None
 1.41A 3o94C-1wytA:
undetectable		 3o94C-1wytA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 11 LEU A 258
PHE A 269
TYR A 113
LEU A 120
ILE A 117
 None
 1.39A 3o94D-1wytA:
undetectable		 3o94D-1wytA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 12 ALA A 138
GLU A 139
LEU B 137
ILE B 314
GLY B 315
 None
 1.10A 3q95A-1wytA:
undetectable		 3q95A-1wytA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 LEU A 137
VAL A 252
VAL A 159
LEU A 123
 None
 0.84A 3rgfA-1wytA:
undetectable		 3rgfA-1wytA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 7 LEU B 207
LEU B 160
PRO B 184
ILE B 183
 None
 0.90A 3s56B-1wytB:
undetectable		 3s56B-1wytB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 5 PHE A  27
ALA B 345
THR A   4
LEU A  23
 None
 1.20A 3t3zC-1wytA:
undetectable		 3t3zC-1wytA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 5 THR B 214
GLY B 216
PRO B 212
ASN B 213
 None
 1.25A 3u8qA-1wytB:
undetectable		 3u8qA-1wytB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 PHE A 378
VAL A 366
LEU A 382
ALA A 379
 None
 1.00A 3uniA-1wytA:
undetectable		 3uniA-1wytA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 7 PRO A 267
GLY A 265
ALA A  64
ASP B  92
 None
 0.88A 3ur0B-1wytA:
undetectable		 3ur0B-1wytA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 8 GLY B 135
GLY B 283
ILE B 142
LEU B 292
VAL B 259
 None
 1.26A 3v1nA-1wytB:
undetectable		 3v1nA-1wytB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 11 ASN B 323
HIS B 134
GLY B 280
PRO B 277
GLY B 275
 None
 1.31A 3v3oC-1wytB:
undetectable		 3v3oC-1wytB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 11 GLY A 253
ASP A 233
VAL A 202
PRO A 243
LEU A 214
 None
 1.25A 3v8vB-1wytA:
2.0		 3v8vB-1wytA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.06A 3wrhE-1wytA:
undetectable		 3wrhE-1wytA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.06A 3wrjE-1wytA:
0.0		 3wrjE-1wytA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.03A 3wrlE-1wytA:
undetectable		 3wrlE-1wytA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.04A 3wrmA-1wytA:
0.0		 3wrmA-1wytA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 11 ARG A 285
GLY A 270
ALA B 133
GLY B 132
GLU B 136
 None
 1.08A 4a6nA-1wytA:
undetectable		 4a6nA-1wytA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 HIS B 166
GLU B 136
ASN A 318
 None
 0.78A 4bupB-1wytB:
undetectable		 4bupB-1wytB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 4 SER B 319
TYR A 163
GLY A 265
PRO B  95
 None
 1.31A 4e3aA-1wytB:
1.2		 4e3aA-1wytB:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 0.98A 4ek1A-1wytA:
0.0		 4ek1A-1wytA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 9 PHE A 415
LEU A 393
VAL A 389
VAL A 363
VAL A 366
 None
 1.34A 4ek1B-1wytA:
0.0		 4ek1B-1wytA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 10 PHE A 217
ALA A 230
LEU A 214
GLY A 215
ALA A 379
 None
 1.27A 4fe1A-1wytA:
undetectable
4fe1J-1wytA:
undetectable		 4fe1A-1wytA:
20.95
4fe1J-1wytA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		3 / 3 PRO B  95
TYR B 321
GLY A 266
 None
 0.56A 4g2zA-1wytB:
undetectable		 4g2zA-1wytB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.08A 4g3rA-1wytA:
0.0		 4g3rA-1wytA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 11 ALA A 224
ALA A 226
ALA A 221
VAL A 202
LEU A 181
 None
 1.15A 4j6cA-1wytA:
undetectable		 4j6cA-1wytA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 10 ALA A 224
ALA A 226
ALA A 221
VAL A 202
LEU A 181
 None
 1.15A 4j6cB-1wytA:
undetectable		 4j6cB-1wytA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		3 / 3 LEU A 334
MET A 116
ASP A 132
 None
 0.80A 4j7xB-1wytA:
undetectable		 4j7xB-1wytA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.09A 4kkyX-1wytA:
0.0		 4kkyX-1wytA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 5 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.06A 4l49A-1wytA:
0.0		 4l49A-1wytA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 5 PHE A 415
LEU A 393
VAL A 389
VAL A 366
 None
 1.22A 4l49A-1wytA:
0.0		 4l49A-1wytA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.06A 4l4cA-1wytA:
0.0		 4l4cA-1wytA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 PHE A 415
LEU A 393
VAL A 389
VAL A 366
 None
 1.13A 4l4cA-1wytA:
0.0		 4l4cA-1wytA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 8 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.00A 4l4cB-1wytA:
undetectable		 4l4cB-1wytA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 7 TYR B 146
VAL B 259
ILE B 140
ARG B 144
ALA B 205
 None
 1.36A 4lv9A-1wytB:
undetectable		 4lv9A-1wytB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		3 / 3 LEU B  35
ARG B  36
MET A 116
 None
 0.93A 4m11C-1wytB:
undetectable		 4m11C-1wytB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 PHE A 375
ALA A 346
ARG A 343
LEU B  35
LEU A 211
 None
 1.47A 4qztC-1wytA:
undetectable		 4qztC-1wytA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 ALA B 205
GLY B 153
ALA A 173
GLY B 177
TYR B 178
 None
 1.12A 4r29A-1wytB:
undetectable		 4r29A-1wytB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 ALA B 205
GLY B 153
ALA A 173
GLY B 177
TYR B 178
 None
 1.17A 4r29B-1wytB:
undetectable		 4r29B-1wytB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 ALA B 205
GLY B 153
ALA A 173
GLY B 177
TYR B 178
 None
 1.14A 4r29C-1wytB:
undetectable		 4r29C-1wytB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		3 / 3 VAL A 389
LEU A 393
VAL A 436
 None
 0.54A 4wq4A-1wytA:
undetectable		 4wq4A-1wytA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 12 THR A 135
LEU A 137
ALA A 138
LEU A 142
GLY B 315
 None
 0.83A 4xi3C-1wytA:
undetectable		 4xi3C-1wytA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 6 LEU B 196
GLU B 194
ILE B 222
PRO B 187
 None
 0.93A 4xi3C-1wytB:
undetectable		 4xi3C-1wytB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 7 ASN B 263
TYR B 333
LEU B 327
PHE B 324
 None
 1.24A 4yv5B-1wytB:
undetectable		 4yv5B-1wytB:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 11 TYR A 170
THR B 138
ALA B 326
ASP A 132
THR A 135
 None
 1.46A 4zjoD-1wytA:
undetectable		 4zjoD-1wytA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 9 PHE A 415
LEU A 393
VAL A 389
VAL A 363
VAL A 366
 None
 1.34A 5cp4A-1wytA:
undetectable		 5cp4A-1wytA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 12 GLY B 216
ILE B 125
GLY B 280
HIS B 375
THR B 214
 None
 1.11A 5eqbA-1wytB:
2.1		 5eqbA-1wytB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 6 PHE A  91
PHE B  68
SER B  58
ASP B  65
 None
 1.07A 5hesA-1wytA:
undetectable		 5hesA-1wytA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 11 MET B 374
LEU B 348
ALA B 347
LEU A  15
HIS A  29
 None
 1.47A 5hyrB-1wytB:
0.0		 5hyrB-1wytB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 MET A 332
VAL A  82
PRO B 277
LEU A 328
GLN A  83
 None
 1.23A 5im2A-1wytA:
undetectable		 5im2A-1wytA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		3 / 3 VAL B 350
ARG B 221
PRO A  31
 None
 0.67A 5koxA-1wytB:
0.0		 5koxA-1wytB:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 12 ASP A 233
LEU A 183
ARG A  74
GLY A  70
LEU A 414
 None
 1.34A 5m50E-1wytA:
undetectable		 5m50E-1wytA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 12 VAL A  50
HIS B  83
THR B 267
GLY B 341
LEU B 342
 None
 1.11A 5m54E-1wytA:
undetectable		 5m54E-1wytA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 12 VAL A  50
HIS B  83
THR B 267
GLY B 341
LEU B 342
 None
 1.09A 5m5cB-1wytA:
2.3		 5m5cB-1wytA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 10 VAL A  50
HIS B  83
THR B 267
GLY B 341
LEU B 342
 None
 1.08A 5m5cE-1wytA:
undetectable		 5m5cE-1wytA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 12 ASP A 385
LEU A 380
ALA A 413
PHE A 415
LEU A 393
 None
 1.24A 5nd4B-1wytA:
2.1		 5nd4B-1wytA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 9 HIS B 134
PRO B 129
GLY B 132
VAL B 282
LEU B 262
 None
 1.22A 5o96E-1wytB:
0.0
5o96F-1wytB:
0.0		 5o96E-1wytB:
21.65
5o96F-1wytB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 9 HIS B 134
PRO B 129
SER B 279
VAL B 282
LEU B 262
 None
 1.38A 5o96E-1wytB:
0.0
5o96F-1wytB:
0.0		 5o96E-1wytB:
21.65
5o96F-1wytB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 12 LEU A 181
PHE A 228
GLY A 223
GLU A 196
GLY A 225
 None
 1.03A 5veuH-1wytA:
undetectable		 5veuH-1wytA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 8 GLY A 244
GLY A 122
GLU A 124
ALA A 118
 None
 0.75A 5vw5A-1wytA:
undetectable		 5vw5A-1wytA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 HIS B 166
GLU B 136
ASN A 318
 None
 0.78A 5wbvA-1wytB:
undetectable		 5wbvA-1wytB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 HIS B 166
GLU B 136
ASN A 318
 None
 0.78A 5wbvB-1wytB:
undetectable		 5wbvB-1wytB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 7 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 0.99A 5wk9A-1wytA:
0.0		 5wk9A-1wytA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 VAL B 317
PRO B 129
ARG B 318
HIS B 265
THR A 326
 None
 1.49A 5xioA-1wytB:
undetectable		 5xioA-1wytB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 VAL B 317
PRO B 129
ARG B 318
HIS B 265
THR A 326
 None
 1.49A 5xioB-1wytB:
undetectable		 5xioB-1wytB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 7 VAL B 260
PRO B 295
MET B 109
LEU B 296
 None
 1.21A 6aycA-1wytB:
undetectable		 6aycA-1wytB:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 5 VAL A 193
LEU A 181
VAL A 159
LEU A 178
 None
 1.02A 6bqgA-1wytA:
undetectable		 6bqgA-1wytA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 LEU A 214
TYR A 163
ASP A 233
GLN A 256
 None
 1.49A 6djzC-1wytA:
undetectable		 6djzC-1wytA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		4 / 6 LEU B  71
THR B  67
ARG B  60
PRO B 453
 None
 1.03A 6ew0G-1wytB:
2.6		 6ew0G-1wytB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		5 / 10 VAL A 389
LEU A 433
LEU A 429
LEU A 380
LEU A 382
 None
 1.02A 6f6nA-1wytA:
undetectable
6f6nB-1wytA:
0.0		 6f6nA-1wytA:
15.88
6f6nB-1wytA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
(Thermus
thermophilus) 		4 / 6 VAL A 389
LEU A 433
LEU A 429
LEU A 380
 None
 0.97A 6f6sA-1wytA:
undetectable
6f6sB-1wytA:
0.0		 6f6sA-1wytA:
15.88
6f6sB-1wytA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)
(Thermus
thermophilus) 		5 / 12 GLY A  71
GLY A  70
LEU A  69
GLY B 322
GLN A 256
 None
 1.04A 6gngB-1wytA:
2.2		 6gngB-1wytA:
21.63