SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_C_377C401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	1wyz	PUTATIVE S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE (Bacteroides thetaiotaomicron)	4 / 6	TYR A 24 GLU A 2 TYR A 6 LEU A 8	None	1.08A	4twdB-1wyzA: undetectable 4twdC-1wyzA: undetectable	4twdB-1wyzA: 20.49 4twdC-1wyzA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_E_377E401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	1wyz	PUTATIVE S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE (Bacteroides thetaiotaomicron)	4 / 6	TYR A 24 GLU A 2 TYR A 6 LEU A 8	None	1.17A	4twdD-1wyzA: undetectable 4twdE-1wyzA: undetectable	4twdD-1wyzA: 20.49 4twdE-1wyzA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_F_377F401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	1wyz	PUTATIVE S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE (Bacteroides thetaiotaomicron)	4 / 7	GLU A 2 TYR A 6 LEU A 8 TYR A 24	None	1.20A	4twdF-1wyzA: 0.0 4twdJ-1wyzA: 0.0	4twdF-1wyzA: 20.49 4twdJ-1wyzA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X3M_B_ADNB301_1 (RNA 2'-O RIBOSE METHYLTRANSFERASE)	1wyz	PUTATIVE S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE (Bacteroides thetaiotaomicron)	5 / 9	LEU A 231 ILE A 201 SER A 122 LEU A 126 VAL A 128	None	0.83A	4x3mB-1wyzA: 2.4	4x3mB-1wyzA: 24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LJE_A_RTLA201_0 (RETINOL-BINDING PROTEIN 1)	1wyz	PUTATIVE S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE (Bacteroides thetaiotaomicron)	5 / 12	LEU A 8 LEU A 47 LEU A 77 PHE A 61 ILE A 32	None	1.08A	5ljeA-1wyzA: undetectable	5ljeA-1wyzA: 20.28

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4TWD_C_377C401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","1wyz","PUTATIVE S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","Bacteroides thetaiotaomicron",4,"TYR A  24;GLU A   2;TYR A   6;LEU A   8","None","1.08A","4twdB-1wyzA:undetectable;4twdC-1wyzA:undetectable","4twdB-1wyzA:20.49;4twdC-1wyzA:20.49"],["4TWD_E_377E401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","1wyz","PUTATIVE S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","Bacteroides thetaiotaomicron",4,"TYR A  24;GLU A   2;TYR A   6;LEU A   8","None","1.17A","4twdD-1wyzA:undetectable;4twdE-1wyzA:undetectable","4twdD-1wyzA:20.49;4twdE-1wyzA:20.49"],["4TWD_F_377F401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","1wyz","PUTATIVE S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","Bacteroides thetaiotaomicron",4,"GLU A   2;TYR A   6;LEU A   8;TYR A  24","None","1.20A","4twdF-1wyzA:0.0;4twdJ-1wyzA:0.0","4twdF-1wyzA:20.49;4twdJ-1wyzA:20.49"],["4X3M_B_ADNB301_1","RNA 2'-O RIBOSE METHYLTRANSFERASE","1wyz","PUTATIVE S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","Bacteroides thetaiotaomicron",5,"LEU A 231;ILE A 201;SER A 122;LEU A 126;VAL A 128","None","0.83A","4x3mB-1wyzA:2.4","4x3mB-1wyzA:24.13"],["5LJE_A_RTLA201_0","RETINOL-BINDING PROTEIN 1","1wyz","PUTATIVE S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","Bacteroides thetaiotaomicron",5,"LEU A   8;LEU A  47;LEU A  77;PHE A  61;ILE A  32","None","1.08A","5ljeA-1wyzA:undetectable","5ljeA-1wyzA:20.28"]]