SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 THR A 191
ASP A 197
HIS A 196
ILE A 512
 None
 0.79A 1ei6D-1wz2A:
0.0		 1ei6D-1wz2A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  53
SER A 532
GLY A 610
ASP A 612
MET A 651
 None
 1.07A 1ffyA-1wz2A:
25.9		 1ffyA-1wz2A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 THR A 319
TYR A 401
GLU A 233
ILE A 427
ALA A 428
 None
 1.30A 1jtxA-1wz2A:
2.2		 1jtxA-1wz2A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 631
ILE A 622
ALA A 627
ARG A 484
GLU A 483
 None
 1.35A 1ki7A-1wz2A:
undetectable		 1ki7A-1wz2A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 TRP A 634
ILE A 622
ALA A 627
ARG A 484
GLU A 483
 None
 1.36A 1ki7B-1wz2A:
undetectable		 1ki7B-1wz2A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 760
LEU A 764
LYS A 808
PHE A 711
 None
 1.02A 1os6A-1wz2A:
undetectable		 1os6A-1wz2A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 11 ALA A  41
HIS A  50
GLY A  52
HIS A  53
GLY A 610
ASP A 612
 None
 0.74A 1pg2A-1wz2A:
28.2		 1pg2A-1wz2A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  53
SER A 532
GLY A 610
ASP A 612
MET A 651
 None
 1.07A 1qu2A-1wz2A:
25.9		 1qu2A-1wz2A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 PHE A 159
SER A 160
THR A  83
THR A 152
 None
 0.98A 1sbrB-1wz2A:
undetectable		 1sbrB-1wz2A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 LYS A 931
GLU A 935
ALA A 926
VAL A 842
 None
 1.12A 1sn5A-1wz2A:
undetectable		 1sn5A-1wz2A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 555
GLU A 164
TYR A 538
 None
 0.76A 1wsvA-1wz2A:
undetectable		 1wsvA-1wz2A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 PHE A 162
PHE A 621
PHE A 629
ILE A  38
 None
 1.29A 2v0mD-1wz2A:
undetectable		 2v0mD-1wz2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 ALA A  41
HIS A  50
HIS A  53
GLY A 610
ASP A 612
 None
 0.88A 2x1lA-1wz2A:
3.7		 2x1lA-1wz2A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A  50
GLY A  52
HIS A  53
GLY A 610
ASP A 612
 None
 0.74A 2x1lA-1wz2A:
3.7		 2x1lA-1wz2A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  41
HIS A  50
HIS A  53
GLY A 610
ASP A 612
 None
 0.87A 2x1lB-1wz2A:
30.1		 2x1lB-1wz2A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  50
GLY A  52
HIS A  53
GLY A 610
ASP A 612
 None
 0.67A 2x1lB-1wz2A:
30.1		 2x1lB-1wz2A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 ALA A  41
HIS A  50
HIS A  53
GLY A 610
ASP A 612
 None
 0.89A 2x1lC-1wz2A:
30.0		 2x1lC-1wz2A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A  50
GLY A  52
HIS A  53
GLY A 610
ASP A 612
 None
 0.74A 2x1lC-1wz2A:
30.0		 2x1lC-1wz2A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A 439
GLU A 438
ILE A 211
ASP A 277
 None
 0.93A 3a7eA-1wz2A:
undetectable		 3a7eA-1wz2A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A 256
PRO A 299
GLY A 435
MET A 431
 None
 1.45A 3aqiA-1wz2A:
0.1		 3aqiA-1wz2A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A 256
PRO A 299
GLY A 435
MET A 431
 None
 1.29A 3aqiB-1wz2A:
0.0		 3aqiB-1wz2A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  81
ASP A 531
GLU A  92
PRO A 122
ILE A  87
 A  C 988 ( 4.1A)
None
None
None
None
 1.46A 3b7pB-1wz2A:
undetectable		 3b7pB-1wz2A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 442
SER A 266
VAL A 265
 None
 0.82A 3eeoA-1wz2A:
undetectable		 3eeoA-1wz2A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A  84
ILE A 125
VAL A 126
 A  C 988 ( 4.7A)
None
None
 0.45A 3nv6A-1wz2A:
1.5		 3nv6A-1wz2A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 760
LEU A 764
LYS A 808
PHE A 711
 None
 0.96A 3selX-1wz2A:
undetectable		 3selX-1wz2A:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 SER A 147
ARG A 148
PRO A  77
VAL A 144
 None
 1.34A 3sufC-1wz2A:
undetectable		 3sufC-1wz2A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 TRP A 465
VAL A 525
TRP A 520
 None
 1.28A 3zq8A-1wz2A:
undetectable
3zq8B-1wz2A:
undetectable		 3zq8A-1wz2A:
1.85
3zq8B-1wz2A:
1.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 849
ASP A 845
ILE A 964
GLN A 956
 A  C 953 ( 4.0A)
G  C 954 ( 3.3A)
G  C 954 ( 4.5A)
None
 0.84A 4ac9C-1wz2A:
undetectable		 4ac9C-1wz2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A 590
HIS A 592
MET A 594
ARG A  28
 None
 1.13A 4ac9B-1wz2A:
undetectable
4ac9C-1wz2A:
undetectable		 4ac9B-1wz2A:
20.50
4ac9C-1wz2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 849
ASP A 845
ILE A 964
GLN A 956
 A  C 953 ( 4.0A)
G  C 954 ( 3.3A)
G  C 954 ( 4.5A)
None
 0.83A 4acaC-1wz2A:
undetectable		 4acaC-1wz2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A 590
HIS A 592
MET A 594
ARG A  28
 None
 1.14A 4acaB-1wz2A:
undetectable
4acaC-1wz2A:
undetectable		 4acaB-1wz2A:
20.50
4acaC-1wz2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 849
ASP A 845
ILE A 964
GLN A 956
 A  C 953 ( 4.0A)
G  C 954 ( 3.3A)
G  C 954 ( 4.5A)
None
 0.79A 4acbC-1wz2A:
undetectable		 4acbC-1wz2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 4 ILE A 590
HIS A 592
MET A 594
ARG A  28
 None
 1.11A 4acbB-1wz2A:
0.0
4acbC-1wz2A:
0.6		 4acbB-1wz2A:
20.50
4acbC-1wz2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 THR A 262
ILE A 223
GLU A 218
PHE A 286
 None
 1.48A 4acbC-1wz2A:
undetectable		 4acbC-1wz2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 GLN A 276
ARG A 256
ASP A 208
GLU A 425
 None
 1.11A 4ax8A-1wz2A:
undetectable		 4ax8A-1wz2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 GLN A 276
ARG A 256
ASP A 208
GLU A 425
 None
 1.13A 4azvA-1wz2A:
undetectable		 4azvA-1wz2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 548
ILE A 545
MET A 594
THR A 584
 None
 0.81A 4do3B-1wz2A:
undetectable		 4do3B-1wz2A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 SER A  46
TYR A 109
PRO A  43
 None
 0.85A 4k8cA-1wz2A:
2.1		 4k8cA-1wz2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 SER A  46
TYR A 109
PRO A  43
 None
 0.84A 4kahA-1wz2A:
2.1		 4kahA-1wz2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 SER A  46
TYR A 109
PRO A  43
 None
 0.84A 4kahB-1wz2A:
undetectable		 4kahB-1wz2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 SER A  46
TYR A 109
PRO A  43
 None
 0.86A 4kanA-1wz2A:
2.3		 4kanA-1wz2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 SER A  46
TYR A 109
PRO A  43
 None
 0.84A 4kanB-1wz2A:
undetectable		 4kanB-1wz2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 SER A  46
TYR A 109
PRO A  43
 None
 0.81A 4kbeA-1wz2A:
undetectable		 4kbeA-1wz2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 SER A  46
TYR A 109
PRO A  43
 None
 0.84A 4kbeB-1wz2A:
2.3		 4kbeB-1wz2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 SER A  46
TYR A 109
PRO A  43
 None
 0.86A 4lbgA-1wz2A:
undetectable		 4lbgA-1wz2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 SER A  46
TYR A 109
PRO A  43
 None
 0.86A 4lbgB-1wz2A:
undetectable		 4lbgB-1wz2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 835
TYR A 864
GLU A 923
 None
 0.84A 4ryaA-1wz2A:
undetectable		 4ryaA-1wz2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A 638
PHE A  66
SER A 609
HIS A 617
 None
 1.30A 4rzvB-1wz2A:
undetectable		 4rzvB-1wz2A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A  75
ASP A 605
ILE A 541
 None
 0.48A 4xi3D-1wz2A:
undetectable		 4xi3D-1wz2A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 822
TRP A 828
ASN A 742
 None
 1.14A 5dv4A-1wz2A:
undetectable		 5dv4A-1wz2A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  50
GLY A  52
HIS A  53
GLY A 610
ASP A 612
 None
 1.05A 5hg0B-1wz2A:
6.5		 5hg0B-1wz2A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 613
ILE A 500
THR A 619
MET A 485
 None
 1.40A 5ljeA-1wz2A:
undetectable		 5ljeA-1wz2A:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 174
TRP A 465
GLN A 464
TYR A 469
 None
 1.22A 5vlmG-1wz2A:
2.3		 5vlmG-1wz2A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A  63
LEU A 744
ILE A 677
ALA A 756
 None
 0.87A 6b5vA-1wz2A:
1.0
6b5vC-1wz2A:
undetectable		 6b5vA-1wz2A:
5.58
6b5vC-1wz2A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A  63
LEU A 744
ILE A 677
ALA A 756
 None
 0.87A 6b5vC-1wz2A:
undetectable
6b5vD-1wz2A:
undetectable		 6b5vC-1wz2A:
5.58
6b5vD-1wz2A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ALA A 756
ILE A  63
LEU A 744
ILE A 677
 None
 0.87A 6b5vB-1wz2A:
undetectable
6b5vD-1wz2A:
undetectable		 6b5vB-1wz2A:
5.58
6b5vD-1wz2A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A 109
HIS A  48
PHE A 129
 None
 1.00A 6esmA-1wz2A:
undetectable		 6esmA-1wz2A:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A 163
THR A 516
THR A 533
LEU A 170
 None
 0.85A 6f3mD-1wz2A:
undetectable		 6f3mD-1wz2A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 1wz2 LEUCYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A  86
ILE A  87
ILE A  90
VAL A 126
ILE A 125
 None
 0.89A 6hlpA-1wz2A:
undetectable		 6hlpA-1wz2A:
20.08