SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 10 LEU A 120
VAL A 111
VAL A 114
TRP A 156
LEU A 124
 None
 1.35A 1fkoA-1wz8A:
undetectable		 1fkoA-1wz8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 VAL A 153
GLY A 149
GLY A  70
ALA A 121
VAL A  97
 None
 1.01A 1jg4A-1wz8A:
undetectable		 1jg4A-1wz8A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 VAL A 153
GLY A 149
GLY A  71
ALA A 121
VAL A  97
 None
None
MPD  A3003 ( 4.1A)
None
None
 1.00A 1jg4A-1wz8A:
undetectable		 1jg4A-1wz8A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 5 LEU A  60
LEU A  12
LEU A   5
LEU A  42
 None
 0.98A 1yajD-1wz8A:
undetectable		 1yajD-1wz8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A  75
GLU A  78
ARG A  88
GLY A 242
LEU A 248
 MPD  A3003 (-4.7A)
None
None
None
None
 1.29A 2j7xA-1wz8A:
undetectable		 2j7xA-1wz8A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 8 ASP A 139
LEU A 169
HIS A 151
LEU A 185
 None
 1.05A 2q0iA-1wz8A:
undetectable		 2q0iA-1wz8A:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 6 LEU A  75
ALA A 118
LEU A  42
ALA A  43
 MPD  A3003 (-4.7A)
MPD  A3003 ( 3.8A)
None
None
 0.97A 2vcvB-1wz8A:
undetectable		 2vcvB-1wz8A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 6 PHE A  67
LEU A  96
PRO A 100
ALA A 109
 None
 0.91A 2vcvB-1wz8A:
undetectable		 2vcvB-1wz8A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 6 LEU A  75
ALA A 118
LEU A  42
ALA A  43
 MPD  A3003 (-4.7A)
MPD  A3003 ( 3.8A)
None
None
 0.97A 2vcvK-1wz8A:
undetectable		 2vcvK-1wz8A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 4 LEU A  12
ARG A  47
LEU A  49
ALA A  43
 None
 1.19A 3b9mA-1wz8A:
undetectable		 3b9mA-1wz8A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 6 GLY A  62
TYR A 196
GLU A 112
GLY A  64
 None
 1.00A 3e9rA-1wz8A:
undetectable		 3e9rA-1wz8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 6 GLY A  62
TYR A 196
GLU A 112
GLY A  64
 None
 0.98A 3e9rC-1wz8A:
undetectable		 3e9rC-1wz8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 10 ALA A 126
LEU A 122
VAL A  58
ALA A  43
LEU A  49
 None
 1.14A 3fl9A-1wz8A:
undetectable		 3fl9A-1wz8A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 11 LEU A  75
GLU A  78
ARG A  88
GLY A 242
LEU A 248
 MPD  A3003 (-4.7A)
None
None
None
None
 1.20A 3hm1B-1wz8A:
undetectable		 3hm1B-1wz8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 ILE A  24
ALA A 199
ALA A  57
VAL A  58
PRO A 100
 None
 1.10A 3jb3A-1wz8A:
undetectable		 3jb3A-1wz8A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 HIS A 141
GLY A 140
VAL A  97
GLY A 119
ALA A  93
 MPD  A3003 (-3.9A)
None
None
None
MPD  A3003 ( 4.4A)
 1.04A 3keeB-1wz8A:
undetectable		 3keeB-1wz8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 HIS A 141
GLY A 140
VAL A  97
GLY A 119
ALA A  93
 MPD  A3003 (-3.9A)
None
None
None
MPD  A3003 ( 4.4A)
 1.06A 3keeC-1wz8A:
undetectable		 3keeC-1wz8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 GLY A  28
LEU A 120
GLY A  70
SER A  68
ALA A 123
 None
 1.02A 3sufA-1wz8A:
undetectable		 3sufA-1wz8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 10 ASP A 139
HIS A 151
GLY A 251
GLY A 117
MET A  79
 None
None
None
None
MPD  A3003 ( 4.0A)
 1.39A 3v3oD-1wz8A:
0.0		 3v3oD-1wz8A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 LEU A   2
GLU A   6
SER A   4
 None
 0.78A 4ccqA-1wz8A:
undetectable		 4ccqA-1wz8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A 236
VAL A 153
GLY A 149
ALA A 148
LEU A 142
 None
 1.14A 4coxA-1wz8A:
undetectable		 4coxA-1wz8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A 236
VAL A 153
GLY A 149
ALA A 148
LEU A 142
 None
 1.14A 4coxB-1wz8A:
undetectable		 4coxB-1wz8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A 236
VAL A 153
GLY A 149
ALA A 148
LEU A 142
 None
 1.15A 4coxD-1wz8A:
undetectable		 4coxD-1wz8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 7 LEU A 124
ALA A 115
VAL A 114
ALA A 180
 None
 0.82A 4g77A-1wz8A:
undetectable		 4g77A-1wz8A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A  75
GLU A  78
ARG A  88
GLY A 242
LEU A 248
 MPD  A3003 (-4.7A)
None
None
None
None
 1.26A 4j26A-1wz8A:
undetectable		 4j26A-1wz8A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A 120
GLY A 119
LEU A  96
MET A  34
VAL A  89
 None
 1.16A 4ok1A-1wz8A:
0.0		 4ok1A-1wz8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A 120
GLY A 119
LEU A  96
MET A  34
VAL A  89
 None
 1.18A 4okxA-1wz8A:
undetectable		 4okxA-1wz8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A 236
VAL A 153
GLY A 149
ALA A 148
LEU A 142
 None
 1.08A 4rrwC-1wz8A:
undetectable		 4rrwC-1wz8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A 236
VAL A 153
GLY A 149
ALA A 148
LEU A 142
 None
 1.02A 4rrwD-1wz8A:
undetectable		 4rrwD-1wz8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A 236
VAL A 153
GLY A 149
ALA A 148
LEU A 142
 None
 1.08A 4rrzC-1wz8A:
undetectable		 4rrzC-1wz8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A 236
VAL A 153
GLY A 149
ALA A 148
LEU A 142
 None
 1.02A 4rrzD-1wz8A:
undetectable		 4rrzD-1wz8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 ILE A  76
SER A  72
GLY A  71
ARG A  88
GLU A  78
 MPD  A3003 ( 4.9A)
None
MPD  A3003 ( 4.1A)
None
None
 1.08A 4xt8A-1wz8A:
undetectable		 4xt8A-1wz8A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 6 GLU A 249
GLY A 117
ASP A 150
GLY A 140
 None
None
MPD  A3003 (-4.3A)
None
 0.93A 5cdnC-1wz8A:
undetectable
5cdnD-1wz8A:
undetectable		 5cdnC-1wz8A:
22.66
5cdnD-1wz8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 6 GLU A 249
GLY A 117
ASP A 150
GLY A 140
 None
None
MPD  A3003 (-4.3A)
None
 0.94A 5cdnT-1wz8A:
undetectable
5cdnU-1wz8A:
undetectable		 5cdnT-1wz8A:
22.66
5cdnU-1wz8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 10 LEU A  75
GLU A  78
ARG A  88
GLY A 242
LEU A 248
 MPD  A3003 (-4.7A)
None
None
None
None
 1.26A 5dx3A-1wz8A:
undetectable		 5dx3A-1wz8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 11 LEU A  75
GLU A  78
ARG A  88
GLY A 242
LEU A 248
 MPD  A3003 (-4.7A)
None
None
None
None
 1.26A 5dxgB-1wz8A:
undetectable		 5dxgB-1wz8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 4 VAL A 146
GLU A 239
GLY A 242
LEU A 248
 None
MPD  A3003 (-3.2A)
None
None
 1.30A 5g5gC-1wz8A:
undetectable		 5g5gC-1wz8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 LEU A  42
LEU A  12
ARG A 105
 None
 0.66A 5hnzB-1wz8A:
undetectable		 5hnzB-1wz8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 HIS A 151
ASP A 150
HIS A 141
 None
MPD  A3003 (-4.3A)
MPD  A3003 (-3.9A)
 0.76A 5oexA-1wz8A:
undetectable		 5oexA-1wz8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 HIS A 151
ASP A 150
HIS A 141
 None
MPD  A3003 (-4.3A)
MPD  A3003 (-3.9A)
 0.69A 5oexB-1wz8A:
undetectable		 5oexB-1wz8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 HIS A 151
ASP A 150
HIS A 141
 None
MPD  A3003 (-4.3A)
MPD  A3003 (-3.9A)
 0.71A 5oexC-1wz8A:
0.0		 5oexC-1wz8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 1wz8 ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 HIS A 151
ASP A 150
HIS A 141
 None
MPD  A3003 (-4.3A)
MPD  A3003 (-3.9A)
 0.74A 5oexD-1wz8A:
undetectable		 5oexD-1wz8A:
19.87