SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wz9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		3 / 3 THR A  37
LEU A  41
VAL A  44
 None
 0.48A 1mz9E-1wz9A:
undetectable		 1mz9E-1wz9A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		4 / 6 VAL A  77
THR A  74
GLU A 115
LEU A  88
 None
 1.03A 1s8fB-1wz9A:
undetectable		 1s8fB-1wz9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		5 / 12 PHE A 175
ILE A 217
LEU A 219
PRO A 220
ILE A 273
 None
CME  A 205 ( 4.4A)
None
None
None
 0.85A 2d0kA-1wz9A:
undetectable		 2d0kA-1wz9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		5 / 11 ALA A  51
ILE A  54
PHE A 104
LEU A 116
ILE A 159
 None
 1.12A 2h42A-1wz9A:
undetectable		 2h42A-1wz9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		5 / 12 ILE A 159
ALA A 314
LEU A 315
PHE A  60
VAL A  44
 None
 1.29A 2yvlC-1wz9A:
undetectable		 2yvlC-1wz9A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		5 / 12 PHE A 372
VAL A 195
THR A 180
PHE A 175
GLU A 328
 CME  A 373 ( 4.7A)
CME  A 183 ( 4.0A)
None
None
None
 1.41A 3apxA-1wz9A:
undetectable		 3apxA-1wz9A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		5 / 12 THR A 108
LEU A  92
ALA A  46
VAL A  66
ILE A 159
 None
 1.03A 3czhB-1wz9A:
undetectable		 3czhB-1wz9A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		4 / 8 GLY A 292
PHE A  70
GLY A  55
PHE A  60
 None
 0.83A 3ko0O-1wz9A:
undetectable
3ko0Q-1wz9A:
0.0		 3ko0O-1wz9A:
14.44
3ko0Q-1wz9A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		5 / 9 GLY A 370
LEU A  19
LEU A  29
ASN A  27
ILE A 282
 None
CME  A  20 ( 4.2A)
None
CME  A 373 (-3.7A)
None
 1.33A 3wdmA-1wz9A:
undetectable		 3wdmA-1wz9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		5 / 9 ARG A  91
LEU A 116
SER A  38
THR A  37
LEU A  41
 None
 1.31A 4ubsA-1wz9A:
undetectable		 4ubsA-1wz9A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		5 / 12 SER A  36
LEU A  35
PRO A  32
PHE A  30
LEU A  15
 None
 1.38A 5jo9A-1wz9A:
undetectable		 5jo9A-1wz9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		3 / 3 ASP A 235
ASN A 213
ASP A 210
 None
CME  A 214 ( 4.8A)
None
 0.84A 5vopA-1wz9A:
undetectable		 5vopA-1wz9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		3 / 3 LYS A 371
ASN A  27
SER A 374
 CME  A  20 ( 3.8A)
CME  A 373 (-3.7A)
CME  A 373 ( 3.5A)
 1.15A 5yw0A-1wz9A:
undetectable		 5yw0A-1wz9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1wz9 MASPIN PRECURSOR
(Homo
sapiens) 		4 / 7 VAL A  57
LEU A  29
PHE A 369
LEU A  19
 None
None
None
CME  A  20 ( 4.2A)
 1.04A 6aycA-1wz9A:
undetectable		 6aycA-1wz9A:
13.42