SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		6 / 12 HIS A  91
TYR A  93
GLU A 260
HIS A 329
ASP A 330
ARG A 379
 None
 0.94A 1dedA-1wzaA:
33.4		 1dedA-1wzaA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		7 / 12 HIS A  91
TYR A  93
ARG A 222
GLU A 260
HIS A 329
ASP A 330
ARG A 379
 None
 0.89A 1dedB-1wzaA:
32.2		 1dedB-1wzaA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 6 TYR A  43
GLY A  55
ASP A  52
GLY A  47
 None
None
CA  A 601 (-3.5A)
None
 0.77A 1eswA-1wzaA:
16.0		 1eswA-1wzaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 11 PRO A 356
ASN A 319
VAL A 315
TYR A 311
GLY A 316
 None
 1.06A 1fkpA-1wzaA:
undetectable		 1fkpA-1wzaA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 11 PRO A 356
VAL A 315
TYR A 308
TYR A 311
GLY A 316
 None
 0.97A 1fkpA-1wzaA:
undetectable		 1fkpA-1wzaA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 LEU A 284
HIS A  31
TYR A 308
ILE A 307
PHE A 317
 None
 1.18A 1fmlA-1wzaA:
undetectable		 1fmlA-1wzaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 LEU A 284
HIS A  31
TYR A 308
ILE A 307
PHE A 317
 None
 1.18A 1fmlB-1wzaA:
undetectable		 1fmlB-1wzaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 11 PRO A 356
VAL A 315
TYR A 308
TYR A 311
GLY A 316
 None
 0.97A 1lwcA-1wzaA:
undetectable		 1lwcA-1wzaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 7 VAL A 315
TYR A 308
TYR A 311
GLY A 316
 None
 0.85A 1lweA-1wzaA:
undetectable		 1lweA-1wzaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		8 / 12 TYR A  93
HIS A 133
PHE A 188
ARG A 222
GLU A 260
TRP A 262
HIS A 329
ASP A 330
 None
 1.14A 1mxdA-1wzaA:
27.9		 1mxdA-1wzaA:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 TYR A  62
LEU A  63
GLY A  51
ILE A  37
LEU A 418
 None
None
CA  A 601 ( 4.9A)
None
None
 1.09A 1p91B-1wzaA:
undetectable		 1p91B-1wzaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 8 VAL A 315
TYR A 308
TYR A 311
GLY A 316
 None
 0.86A 1s1xA-1wzaA:
undetectable		 1s1xA-1wzaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 5 VAL A 218
GLY A 220
VAL A 125
TRP A  80
 None
 1.33A 1tkqB-1wzaA:
undetectable		 1tkqB-1wzaA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 8 MET A  82
TYR A  90
TYR A  93
HIS A 329
 None
 1.15A 2bteA-1wzaA:
undetectable		 2bteA-1wzaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 8 MET A  82
TYR A  90
TYR A  93
HIS A 329
 None
 1.17A 2bteD-1wzaA:
undetectable		 2bteD-1wzaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 7 MET A  82
TYR A  90
TYR A  93
HIS A 329
 None
 1.17A 2bytA-1wzaA:
undetectable		 2bytA-1wzaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 7 MET A  82
TYR A  90
TYR A  93
HIS A 329
 None
 1.17A 2bytD-1wzaA:
undetectable		 2bytD-1wzaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 11 TYR A  35
GLY A 364
GLY A 368
ILE A  37
PHE A  42
 None
 1.50A 2dr2A-1wzaA:
undetectable		 2dr2A-1wzaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 8 MET A  82
TYR A  90
TYR A  93
HIS A 329
 None
 1.21A 2v0gA-1wzaA:
undetectable		 2v0gA-1wzaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 PRO A 324
ALA A 323
ALA A 292
THR A 509
LEU A 424
 None
 1.24A 2x2nB-1wzaA:
undetectable		 2x2nB-1wzaA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 6 GLY A  32
TYR A 256
GLY A  78
ASN A 358
 None
 1.04A 3e9rA-1wzaA:
undetectable		 3e9rA-1wzaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 9 ASP A 110
ILE A  56
GLY A  51
ILE A  50
ILE A  84
 None
None
CA  A 601 ( 4.9A)
CA  A 601 (-4.8A)
None
 1.11A 3ekyB-1wzaA:
undetectable		 3ekyB-1wzaA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 10 ASN A 319
VAL A 315
TYR A 308
TYR A 311
GLY A 316
 None
 0.98A 3lp1A-1wzaA:
undetectable		 3lp1A-1wzaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 PRO A 356
ASN A 319
VAL A 315
TYR A 308
TYR A 311
 None
 1.12A 3megA-1wzaA:
0.4		 3megA-1wzaA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 5 ARG A  40
ASP A  44
ASP A  48
ASP A  46
 None
CA  A 601 (-3.3A)
CA  A 601 (-2.8A)
CA  A 601 (-3.1A)
 1.44A 3naiC-1wzaA:
0.0		 3naiC-1wzaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 8 TYR A  98
TYR A 197
LEU A 223
TRP A 242
 None
 0.88A 3uzzB-1wzaA:
8.4		 3uzzB-1wzaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 7 ALA A  72
ILE A  71
HIS A 426
GLY A  75
 None
 0.94A 3v4tH-1wzaA:
undetectable		 3v4tH-1wzaA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 5 GLU A 392
GLY A 391
TYR A 394
ASP A  48
 None
None
None
CA  A 601 (-2.8A)
 1.18A 3w9tD-1wzaA:
undetectable		 3w9tD-1wzaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 6 TYR A 352
ARG A 428
ASP A 322
TYR A 435
 None
 1.32A 3wfaA-1wzaA:
14.5
3wfaB-1wzaA:
10.5		 3wfaA-1wzaA:
20.92
3wfaB-1wzaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 8 ASP A  52
ASP A  44
ASP A 110
GLU A 109
 CA  A 601 (-3.5A)
CA  A 601 (-3.3A)
None
None
 1.05A 4feuD-1wzaA:
4.0		 4feuD-1wzaA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 7 ILE A  56
LEU A  81
PHE A 111
GLY A 217
 None
 0.96A 4hajA-1wzaA:
undetectable		 4hajA-1wzaA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 TYR A  34
GLY A  32
ASN A  77
ILE A 321
PHE A  28
 None
 1.19A 4kosA-1wzaA:
undetectable		 4kosA-1wzaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 TYR A  34
GLY A  32
ASN A  77
ILE A 321
PHE A  28
 None
 1.24A 4kotA-1wzaA:
undetectable		 4kotA-1wzaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 TYR A  34
GLY A  32
ASN A  77
ILE A 321
PHE A  28
 None
 1.26A 4kovA-1wzaA:
undetectable		 4kovA-1wzaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 6 ASN A 419
GLU A 411
GLU A 366
TYR A 421
 None
 1.36A 4mi4A-1wzaA:
0.9		 4mi4A-1wzaA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 8 PRO A 356
VAL A 315
TYR A 308
TYR A 311
 None
 0.83A 4pwdA-1wzaA:
undetectable		 4pwdA-1wzaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 GLY A  55
TYR A 362
ILE A 334
GLY A 368
THR A 405
 None
 1.19A 4zdyA-1wzaA:
undetectable		 4zdyA-1wzaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 GLY A  55
TYR A 362
ILE A 334
GLY A 368
THR A 405
 None
 1.21A 5eslA-1wzaA:
undetectable		 5eslA-1wzaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 11 PRO A 356
VAL A 315
TYR A 308
TYR A 311
GLY A 316
 None
 0.96A 5hbmA-1wzaA:
0.0		 5hbmA-1wzaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 5 ILE A  56
ILE A 123
HIS A 119
VAL A 125
 None
 0.73A 5jmnA-1wzaA:
undetectable		 5jmnA-1wzaA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 7 HIS A 420
LEU A 417
VAL A 347
SER A 350
 None
 0.99A 5m8rA-1wzaA:
undetectable		 5m8rA-1wzaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 8 HIS A 420
LEU A 417
VAL A 347
SER A 350
 None
 0.98A 5m8rB-1wzaA:
undetectable		 5m8rB-1wzaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 8 HIS A 420
LEU A 417
VAL A 347
SER A 350
 None
 0.97A 5m8rD-1wzaA:
undetectable		 5m8rD-1wzaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 GLY A  78
ILE A  79
TYR A 256
VAL A 258
LEU A 114
 None
 1.42A 5nz0A-1wzaA:
0.0		 5nz0A-1wzaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 ASP A 277
LEU A 114
PHE A  28
PHE A 111
ALA A 210
 None
 1.06A 5vc0A-1wzaA:
undetectable		 5vc0A-1wzaA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 5 ASN A 328
GLN A 331
ASP A 330
ARG A 379
 None
 1.49A 5w4zA-1wzaA:
11.1		 5w4zA-1wzaA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 ALA A 304
PHE A 451
ASN A 281
GLY A 357
THR A  33
 None
 1.03A 5x24A-1wzaA:
undetectable		 5x24A-1wzaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 VAL A 449
PHE A 451
PHE A 300
GLN A 331
PRO A 356
 None
 1.08A 6becA-1wzaA:
undetectable
6becB-1wzaA:
undetectable
6becC-1wzaA:
undetectable		 6becA-1wzaA:
21.61
6becB-1wzaA:
21.61
6becC-1wzaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 8 VAL A 448
ILE A 504
THR A 508
TYR A 507
 None
 1.02A 6cduG-1wzaA:
undetectable
6cduH-1wzaA:
undetectable		 6cduG-1wzaA:
21.44
6cduH-1wzaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		4 / 5 TYR A 256
LYS A 124
GLY A 318
ILE A 321
 None
 1.46A 6debB-1wzaA:
undetectable		 6debB-1wzaA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 ILE A 351
GLY A 295
ALA A 294
ILE A 289
LEU A 338
 None
 1.02A 6dwnD-1wzaA:
undetectable		 6dwnD-1wzaA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1wza ALPHA-AMYLASE A
(Halothermothrix
orenii) 		5 / 12 GLY A  55
TYR A 362
ILE A 334
GLY A 368
THR A 405
 None
 1.18A 6e8qA-1wzaA:
undetectable		 6e8qA-1wzaA:
9.22