SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wzc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 5 LYS A 185
ALA A 184
ASP A 179
GLY A  65
 None
 1.12A 1e7cA-1wzcA:
undetectable		 1e7cA-1wzcA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 203
ASP A 208
GLY A 168
TYR A 206
 None
MG  A 300 ( 4.4A)
None
None
 0.95A 1eswA-1wzcA:
undetectable		 1eswA-1wzcA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 8 ARG A  44
ASN A  64
SER A  66
ARG A  95
 None
 0.75A 1u1jA-1wzcA:
undetectable		 1u1jA-1wzcA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A  51
GLU A  53
PRO A  19
ALA A  22
 None
 1.47A 2ejfB-1wzcA:
undetectable		 2ejfB-1wzcA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 VAL A 215
LEU A  92
ALA A 184
LEU A 188
 None
 0.88A 3kk6B-1wzcA:
undetectable		 3kk6B-1wzcA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 235
THR A  12
THR A  58
VAL A  56
ILE A  26
 None
MG  A 300 ( 4.9A)
None
None
None
 1.39A 4i41A-1wzcA:
undetectable		 4i41A-1wzcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 141
GLY A  65
ALA A 183
PHE A  60
ILE A  90
 None
 1.19A 4xe5A-1wzcA:
5.4		 4xe5A-1wzcA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 8 ASP A   8
ASP A 208
ASP A 204
TYR A 172
 MG  A 300 ( 2.5A)
MG  A 300 ( 4.4A)
MG  A 300 (-2.7A)
None
 0.97A 4xjeA-1wzcA:
undetectable		 4xjeA-1wzcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 LYS A  42
ARG A 170
ASP A  10
TYR A  50
 PO4  A 401 ( 4.9A)
None
PO4  A 401 ( 4.6A)
None
 1.46A 5a06A-1wzcA:
4.8		 5a06A-1wzcA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 LYS A  42
ARG A 170
ASP A  10
TYR A  50
 PO4  A 401 ( 4.9A)
None
PO4  A 401 ( 4.6A)
None
 1.47A 5a06C-1wzcA:
4.9		 5a06C-1wzcA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 LYS A  42
ARG A 170
ASP A  10
TYR A  50
 PO4  A 401 ( 4.9A)
None
PO4  A 401 ( 4.6A)
None
 1.45A 5a06D-1wzcA:
5.1		 5a06D-1wzcA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 LYS A  42
ARG A 170
ASP A  10
TYR A  50
 PO4  A 401 ( 4.9A)
None
PO4  A 401 ( 4.6A)
None
 1.47A 5a06E-1wzcA:
4.8		 5a06E-1wzcA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 7 LYS A  42
ARG A 170
ASP A  10
TYR A  50
 PO4  A 401 ( 4.9A)
None
PO4  A 401 ( 4.6A)
None
 1.45A 5a06F-1wzcA:
4.9		 5a06F-1wzcA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 8 ASP A   8
ASP A 208
ASP A 204
TYR A 172
 MG  A 300 ( 2.5A)
MG  A 300 ( 4.4A)
MG  A 300 (-2.7A)
None
 1.00A 5cfsA-1wzcA:
undetectable		 5cfsA-1wzcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		5 / 10 VAL A 218
HIS A 226
LEU A 224
THR A 166
GLY A 181
 None
 1.26A 5m5cE-1wzcA:
undetectable		 5m5cE-1wzcA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A  37
ALA A 184
LEU A 187
ILE A  68
 None
 0.87A 5mvmB-1wzcA:
undetectable
5mvmC-1wzcA:
undetectable		 5mvmB-1wzcA:
14.06
5mvmC-1wzcA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 224
SER A 205
PHE A 209
ASP A 208
 None
None
None
MG  A 300 ( 4.4A)
 1.23A 5om3A-1wzcA:
undetectable
5om3B-1wzcA:
0.0		 5om3A-1wzcA:
13.25
5om3B-1wzcA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 SER A 118
ARG A 140
GLU A 144
TYR A 115
 None
 1.16A 5x7qB-1wzcA:
undetectable		 5x7qB-1wzcA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Pyrococcus
horikoshii) 		4 / 6 SER A 118
ARG A 140
GLU A 144
TYR A 115
 None
 1.17A 5x7rB-1wzcA:
undetectable		 5x7rB-1wzcA:
11.61