SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 144
VAL A  23
ILE A  27
ILE A  33
PHE A 112
 None
 1.38A 1fkfA-1wznA:
undetectable		 1fkfA-1wznA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 144
VAL A  23
ILE A  27
ILE A  33
PHE A 112
 None
 1.40A 1fkjA-1wznA:
undetectable		 1fkjA-1wznA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 144
VAL A  23
ILE A  27
ILE A  33
PHE A 112
 None
 1.40A 1q6iB-1wznA:
undetectable		 1q6iB-1wznA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 234
TYR A 229
LYS A 227
 None
 0.97A 1uujB-1wznA:
undetectable		 1uujB-1wznA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 144
VAL A  23
ILE A  27
ILE A  33
PHE A 112
 None
 1.38A 2fkeA-1wznA:
undetectable		 2fkeA-1wznA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 TYR A  16
TYR A  12
TYR A   5
ASP A 172
 None
SAH  A1001 (-4.9A)
SAH  A1001 (-3.5A)
None
 1.16A 2g72A-1wznA:
14.6		 2g72A-1wznA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 TYR A  12
GLY A  51
ASP A  70
ASP A  96
 SAH  A1001 (-4.9A)
SAH  A1001 (-3.1A)
SAH  A1001 (-2.7A)
SAH  A1001 (-3.3A)
 0.61A 2g72B-1wznA:
14.6		 2g72B-1wznA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 ALA A  25
ASP A  28
GLU A  26
ARG A 242
 None
 1.36A 2ouzA-1wznA:
undetectable		 2ouzA-1wznA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 ALA A  49
GLY A  51
ASP A  70
ASP A  96
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
SAH  A1001 (-2.7A)
SAH  A1001 (-3.3A)
 0.62A 2uyqA-1wznA:
11.7		 2uyqA-1wznA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  51
PRO A  55
ASP A  96
VAL A  97
PHE A 119
 SAH  A1001 (-3.1A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.5A)
SAH  A1001 (-4.8A)
 1.29A 2zznA-1wznA:
15.1		 2zznA-1wznA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		6 / 12 ALA A  49
GLY A  51
LEU A  71
MET A  75
PHE A 113
TYR A 118
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.4A)
None
SAH  A1001 ( 4.6A)
 0.46A 3bxoA-1wznA:
25.1		 3bxoA-1wznA:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  49
GLY A  51
MET A  75
PHE A 113
LEU A 127
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
SAH  A1001 (-4.4A)
None
None
 1.29A 3bxoA-1wznA:
25.1		 3bxoA-1wznA:
30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		6 / 12 ALA A  49
GLY A  51
LEU A  71
MET A  75
PHE A 113
TYR A 118
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.4A)
None
SAH  A1001 ( 4.6A)
 0.53A 3bxoB-1wznA:
25.0		 3bxoB-1wznA:
30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 228
PHE A 141
PHE A 223
LYS A 225
 None
 1.09A 3em0B-1wznA:
3.5		 3em0B-1wznA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  49
GLY A  51
LEU A  69
LEU A  71
ASP A  96
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
None
SAH  A1001 (-3.9A)
SAH  A1001 (-3.3A)
 0.35A 3g2oB-1wznA:
19.0		 3g2oB-1wznA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 144
VAL A  23
ILE A  27
ILE A  33
PHE A 112
 None
 1.43A 3ihzA-1wznA:
undetectable		 3ihzA-1wznA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  48
CYH A  50
THR A  56
ILE A  90
PHE A  92
 None
 1.27A 3mnoA-1wznA:
undetectable		 3mnoA-1wznA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A   5
ALA A  49
GLY A  51
MET A  75
ASP A  96
 SAH  A1001 (-3.5A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.3A)
 0.96A 3ou6A-1wznA:
19.0		 3ou6A-1wznA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A  12
ASP A  70
ASP A  96
 SAH  A1001 (-4.9A)
SAH  A1001 (-2.7A)
SAH  A1001 (-3.3A)
 0.41A 3ou6B-1wznA:
17.7		 3ou6B-1wznA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A  12
GLY A  51
ASP A  70
 SAH  A1001 (-4.9A)
SAH  A1001 (-3.1A)
SAH  A1001 (-2.7A)
 0.19A 3ou6C-1wznA:
19.1		 3ou6C-1wznA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A   5
TYR A  12
ALA A  49
MET A  75
ASP A  96
 SAH  A1001 (-3.5A)
SAH  A1001 (-4.9A)
SAH  A1001 (-3.4A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.3A)
 1.04A 3ou6D-1wznA:
18.9		 3ou6D-1wznA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		6 / 12 TYR A   5
TYR A  12
ALA A  49
GLY A  51
MET A  75
ASP A  96
 SAH  A1001 (-3.5A)
SAH  A1001 (-4.9A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.3A)
 0.93A 3ou7A-1wznA:
18.9		 3ou7A-1wznA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A   5
ASP A  70
ASP A  96
 SAH  A1001 (-3.5A)
SAH  A1001 (-2.7A)
SAH  A1001 (-3.3A)
 0.64A 3ou7B-1wznA:
19.1		 3ou7B-1wznA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A  51
ASP A  70
ASP A  96
 SAH  A1001 (-3.1A)
SAH  A1001 (-2.7A)
SAH  A1001 (-3.3A)
 0.35A 3ou7C-1wznA:
19.0		 3ou7C-1wznA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		6 / 12 TYR A   5
TYR A  12
ALA A  49
GLY A  51
MET A  75
ASP A  96
 SAH  A1001 (-3.5A)
SAH  A1001 (-4.9A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.3A)
 0.97A 3ou7D-1wznA:
19.0		 3ou7D-1wznA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		7 / 12 TYR A   5
ALA A  49
GLY A  51
LEU A  71
MET A  75
ASP A  96
PHE A 113
 SAH  A1001 (-3.5A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.3A)
None
 0.28A 3pfgA-1wznA:
26.5		 3pfgA-1wznA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A  13
GLY A  53
TYR A  12
 None
None
SAH  A1001 (-4.9A)
 0.64A 3w9tC-1wznA:
undetectable		 3w9tC-1wznA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A  13
GLY A  53
TYR A  12
 None
None
SAH  A1001 (-4.9A)
 0.64A 3w9tG-1wznA:
undetectable		 3w9tG-1wznA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 4 ASP A  47
GLY A  51
ASP A  70
ASP A  96
 SAH  A1001 ( 4.8A)
SAH  A1001 (-3.1A)
SAH  A1001 (-2.7A)
SAH  A1001 (-3.3A)
 0.60A 5e72A-1wznA:
15.8		 5e72A-1wznA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1wzn SAM-DEPENDENT
METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  49
GLY A  51
LEU A  71
MET A  75
LEU A  98
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.4A)
None
 0.76A 5jglB-1wznA:
14.8		 5jglB-1wznA:
22.22