SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wzo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 1wzo HPCE
(Thermus
thermophilus) 		5 / 12 THR A 124
ARG A   5
LEU A  39
LEU A 212
ILE A  46
 None
 1.30A 1kqwA-1wzoA:
undetectable		 1kqwA-1wzoA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1wzo HPCE
(Thermus
thermophilus) 		4 / 5 ARG A 110
MET A 203
THR A 204
LEU A 205
 None
 1.41A 2eimW-1wzoA:
undetectable		 2eimW-1wzoA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1wzo HPCE
(Thermus
thermophilus) 		5 / 10 MET A 108
ALA A 113
ALA A 193
LEU A 211
VAL A 102
 None
 1.44A 2wuzB-1wzoA:
undetectable		 2wuzB-1wzoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1wzo HPCE
(Thermus
thermophilus) 		3 / 3 ASP A  24
HIS A  30
HIS A  13
 None
 0.71A 2xxgC-1wzoA:
undetectable		 2xxgC-1wzoA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 1wzo HPCE
(Thermus
thermophilus) 		4 / 8 ASP A 128
LYS A 146
GLY A 214
GLU A  99
 NA  A1007 (-3.1A)
NA  A1007 (-3.4A)
NA  A1007 ( 4.5A)
NA  A1007 (-2.6A)
 0.90A 2ys6A-1wzoA:
undetectable		 2ys6A-1wzoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1wzo HPCE
(Thermus
thermophilus) 		4 / 5 ARG A 110
MET A 203
THR A 204
LEU A 205
 None
 1.43A 3ag2J-1wzoA:
undetectable		 3ag2J-1wzoA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 1wzo HPCE
(Thermus
thermophilus) 		4 / 8 ASN A 240
LYS A  82
PRO A  40
PHE A  41
 None
 1.48A 3bjwD-1wzoA:
undetectable		 3bjwD-1wzoA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1wzo HPCE
(Thermus
thermophilus) 		4 / 7 ALA A 116
VAL A 102
VAL A 120
LEU A 117
 None
 0.82A 3o14A-1wzoA:
undetectable		 3o14A-1wzoA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1wzo HPCE
(Thermus
thermophilus) 		4 / 5 ASP A 168
THR A 185
LEU A 169
GLU A 233
 None
 1.46A 4a3pA-1wzoA:
undetectable		 4a3pA-1wzoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 1wzo HPCE
(Thermus
thermophilus) 		3 / 3 GLN A 221
HIS A  95
ARG A 132
 None
 0.86A 4qyqA-1wzoA:
undetectable		 4qyqA-1wzoA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 1wzo HPCE
(Thermus
thermophilus) 		3 / 3 GLN A 221
HIS A  95
ARG A 132
 None
 0.80A 4qyqB-1wzoA:
undetectable		 4qyqB-1wzoA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_ACTA502_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1wzo HPCE
(Thermus
thermophilus) 		4 / 4 LYS A 146
ARG A 148
GLY A 147
ASP A 128
 NA  A1007 (-3.4A)
None
None
NA  A1007 (-3.1A)
 1.33A 4ryaA-1wzoA:
0.0		 4ryaA-1wzoA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1wzo HPCE
(Thermus
thermophilus) 		4 / 6 PRO A  65
LEU A 195
GLU A 194
TYR A 190
 None
 1.35A 4z4cA-1wzoA:
undetectable		 4z4cA-1wzoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1wzo HPCE
(Thermus
thermophilus) 		4 / 4 GLN A 167
THR A 185
THR A 124
LEU A 212
 None
 1.27A 5m66B-1wzoA:
undetectable		 5m66B-1wzoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1wzo HPCE
(Thermus
thermophilus) 		3 / 3 GLY A  44
THR A  42
ASN A  75
 None
 0.68A 5odiG-1wzoA:
undetectable		 5odiG-1wzoA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 1wzo HPCE
(Thermus
thermophilus) 		4 / 4 GLN A 167
THR A 185
THR A 124
LEU A 212
 None
 1.34A 6f3mB-1wzoA:
undetectable		 6f3mB-1wzoA:
21.29