SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 1wzx COG3291: FOG: PKD
REPEAT
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 123
PHE A 172
ILE A 175
PHE A 160
 None
 1.06A 2q6hA-1wzxA:
undetectable		 2q6hA-1wzxA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1wzx COG3291: FOG: PKD
REPEAT
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 123
PHE A 172
ILE A 175
PHE A 160
 None
 1.06A 2qb4A-1wzxA:
undetectable		 2qb4A-1wzxA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1wzx COG3291: FOG: PKD
REPEAT
(Ruminiclostridiu
m
thermocellum) 		3 / 3 PHE A  89
TYR A  86
LEU A  48
 None
 0.79A 3sueB-1wzxA:
undetectable		 3sueB-1wzxA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1wzx COG3291: FOG: PKD
REPEAT
(Ruminiclostridiu
m
thermocellum) 		4 / 8 VAL A  11
ILE A 177
ILE A 138
PHE A 104
 None
 0.91A 3uqbA-1wzxA:
undetectable		 3uqbA-1wzxA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1wzx COG3291: FOG: PKD
REPEAT
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A  96
GLY A  97
PHE A 100
GLY A  93
VAL A 170
 None
 0.89A 4o33A-1wzxA:
undetectable		 4o33A-1wzxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1wzx COG3291: FOG: PKD
REPEAT
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A  52
ASP A  40
TRP A 171
 None
 1.22A 4xdqA-1wzxA:
undetectable		 4xdqA-1wzxA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1wzx COG3291: FOG: PKD
REPEAT
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 138
LEU A 143
VAL A 155
ILE A  13
LEU A  70
 None
 1.10A 5ienA-1wzxA:
undetectable		 5ienA-1wzxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 1wzx COG3291: FOG: PKD
REPEAT
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ILE A 138
LEU A 143
VAL A 155
ILE A  13
LEU A  70
 None
 1.09A 5ienB-1wzxA:
undetectable		 5ienB-1wzxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 1wzx COG3291: FOG: PKD
REPEAT
(Ruminiclostridiu
m
thermocellum) 		3 / 3 PHE A  89
ASP A 174
LYS A 176
 None
 0.83A 6awtD-1wzxA:
undetectable		 6awtD-1wzxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 1wzx COG3291: FOG: PKD
REPEAT
(Ruminiclostridiu
m
thermocellum) 		4 / 4 PHE A  89
ASP A 174
LEU A  87
LYS A 176
 None
 1.08A 6awvA-1wzxA:
0.0		 6awvA-1wzxA:
20.10