SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1wzz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 11 LEU A 300
ALA A 301
GLU A 304
LEU A 314
ILE A  33
 None
 0.92A 1g50A-1wzzA:
undetectable		 1g50A-1wzzA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 10 LEU A 300
ALA A 301
GLU A 304
LEU A 314
LEU A 317
 None
 1.19A 1gwrA-1wzzA:
undetectable		 1gwrA-1wzzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 6 ASN A 110
HIS A  88
ALA A 164
GLY A 163
 None
 1.14A 1l7xB-1wzzA:
undetectable		 1l7xB-1wzzA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 12 LEU A 328
LEU A 331
ALA A 335
ARG A 125
ILE A 247
 None
 1.06A 1s9pA-1wzzA:
undetectable		 1s9pA-1wzzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 12 LEU A 328
LEU A 331
ALA A 335
GLU A 338
ILE A 247
 None
 1.04A 1s9pD-1wzzA:
undetectable		 1s9pD-1wzzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 4 LEU A 218
PRO A 219
LEU A 285
ARG A 241
 None
 1.37A 2hrcA-1wzzA:
undetectable		 2hrcA-1wzzA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 7 ASN A 110
GLY A 163
THR A 113
SER A  56
 None
 1.25A 2o5yH-1wzzA:
undetectable
2o5yL-1wzzA:
undetectable		 2o5yH-1wzzA:
19.64
2o5yL-1wzzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 8 MET A  78
LEU A  39
LEU A 330
GLY A  70
 None
 0.93A 2po5A-1wzzA:
undetectable		 2po5A-1wzzA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 8 MET A  78
LEU A  39
LEU A 330
GLY A  70
 None
 0.97A 2po5B-1wzzA:
undetectable		 2po5B-1wzzA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 8 GLY A 124
ALA A 139
ASP A 138
LEU A 118
VAL A 146
 None
 1.41A 3em6A-1wzzA:
undetectable		 3em6A-1wzzA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 12 LEU A 300
ALA A 301
GLU A 304
LEU A 314
ILE A  33
 None
 0.92A 3q95B-1wzzA:
undetectable		 3q95B-1wzzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 6 LEU A 251
ALA A 337
THR A 340
LEU A 314
 None
 0.90A 3t3zA-1wzzA:
undetectable		 3t3zA-1wzzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 6 LEU A 251
ALA A 337
THR A 340
LEU A 314
 None
 0.90A 3t3zB-1wzzA:
undetectable		 3t3zB-1wzzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 6 LEU A 251
ALA A 337
THR A 340
LEU A 314
 None
 0.90A 3t3zD-1wzzA:
undetectable		 3t3zD-1wzzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 9 ALA A 126
ALA A  69
ASP A  71
ARG A 129
LEU A  72
 None
 1.38A 3ur0C-1wzzA:
0.0		 3ur0C-1wzzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 12 PHE A  65
GLY A  60
GLY A  58
VAL A  45
ARG A 248
 None
 0.98A 4a6dA-1wzzA:
undetectable		 4a6dA-1wzzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 12 PHE A  65
GLY A  60
GLY A  58
VAL A  45
ARG A 248
 None
 1.00A 4a6eA-1wzzA:
undetectable		 4a6eA-1wzzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		3 / 3 MET A 150
MET A 201
TYR A 179
 None
 1.33A 4p6xI-1wzzA:
undetectable		 4p6xI-1wzzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 12 LEU A 300
ALA A 301
GLU A 304
LEU A 314
LEU A 317
 None
 1.09A 4pxmA-1wzzA:
undetectable		 4pxmA-1wzzA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 11 LEU A 300
ALA A 301
GLU A 304
LEU A 314
ILE A  33
 None
 0.97A 4pxmB-1wzzA:
undetectable		 4pxmB-1wzzA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 7 THR A 329
LEU A 330
THR A 316
LEU A 317
 None
 0.94A 4z90A-1wzzA:
undetectable
4z90B-1wzzA:
undetectable
4z90C-1wzzA:
undetectable
4z90D-1wzzA:
undetectable
4z90E-1wzzA:
undetectable		 4z90A-1wzzA:
22.43
4z90B-1wzzA:
22.43
4z90C-1wzzA:
22.43
4z90D-1wzzA:
22.43
4z90E-1wzzA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 11 LEU A 300
ALA A 301
GLU A 304
LEU A 314
LEU A 317
 None
 1.11A 5dxgB-1wzzA:
undetectable		 5dxgB-1wzzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 10 LEU A 331
ALA A 335
GLU A 338
LEU A 121
ARG A 125
 None
 1.41A 5hyrA-1wzzA:
undetectable		 5hyrA-1wzzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 11 LEU A 300
ALA A 301
GLU A 304
LEU A 314
LEU A 317
 None
 1.11A 5hyrB-1wzzA:
0.0		 5hyrB-1wzzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 11 SER A  95
PHE A  94
ASP A  91
VAL A 146
LEU A 117
 None
 1.46A 5jdcA-1wzzA:
undetectable
5jdcD-1wzzA:
undetectable		 5jdcA-1wzzA:
23.60
5jdcD-1wzzA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 12 LEU A 300
ALA A 301
GLU A 304
LEU A 314
LEU A 317
 None
 0.95A 5toaA-1wzzA:
undetectable		 5toaA-1wzzA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 8 GLY A  62
GLN A 187
TYR A 143
ASP A  71
 None
 1.03A 5vlmB-1wzzA:
undetectable		 5vlmB-1wzzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 7 GLN A  59
GLY A  62
GLN A 187
TYR A 143
ASP A  71
 None
 1.14A 5vlmE-1wzzA:
undetectable		 5vlmE-1wzzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 5 SER A 291
TYR A 293
GLY A 281
TYR A 244
 None
 1.49A 5yodH-1wzzA:
undetectable		 5yodH-1wzzA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		5 / 10 LEU A 300
ALA A 301
GLU A 304
LEU A 314
ILE A  33
 None
 0.97A 6cbzB-1wzzA:
undetectable		 6cbzB-1wzzA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 6 ASP A 114
TYR A  61
ASP A  47
GLU A  53
 None
 1.48A 6mn5A-1wzzA:
undetectable		 6mn5A-1wzzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1wzz PROBABLE
ENDOGLUCANASE
(Komagataeibacter
xylinus) 		4 / 6 ASP A 114
TYR A  61
ASP A  47
GLU A  53
 None
 1.30A 6mn5C-1wzzA:
undetectable		 6mn5C-1wzzA:
16.55