SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x03'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1x03 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Homo
sapiens) 		4 / 7 TYR A 225
HIS A 226
LEU A  68
GLN A  59
 None
 0.78A 3jwqC-1x03A:
undetectable		 3jwqC-1x03A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1x03 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 GLU A 162
LEU A 166
LEU A 187
 None
 0.55A 3ohtA-1x03A:
2.1		 3ohtA-1x03A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1x03 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 GLU A 162
LEU A 166
LEU A 187
 None
 0.54A 3ohtB-1x03A:
2.0		 3ohtB-1x03A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 1x03 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 ARG A 165
LYS A  28
LYS A  26
 None
 1.08A 4k50A-1x03A:
undetectable		 4k50A-1x03A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 1x03 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 ARG A 165
LYS A  28
LYS A  26
 None
 1.01A 4k50I-1x03A:
undetectable		 4k50I-1x03A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1x03 SH3-CONTAINING
GRB2-LIKE PROTEIN 2
(Homo
sapiens) 		4 / 6 SER A  44
ASP A 148
GLN A 155
THR A  52
 None
 1.32A 6djzA-1x03A:
undetectable		 6djzA-1x03A:
22.63