SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 11 ALA A  89
TRP A 134
ASP A 172
GLY A 120
ALA A 174
 None
None
NA  A 403 (-4.6A)
None
FMT  A 401 (-3.7A)
 1.06A 1b02A-1x0aA:
undetectable		 1b02A-1x0aA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 7 GLY A 181
ASP A 172
SER A  43
ALA A 119
 None
NA  A 403 (-4.6A)
None
None
 0.73A 1gxsA-1x0aA:
undetectable
1gxsB-1x0aA:
undetectable		 1gxsA-1x0aA:
23.25
1gxsB-1x0aA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A 302
PRO A 303
LEU A 169
 None
 0.48A 1hrkA-1x0aA:
undetectable		 1hrkA-1x0aA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A 277
LEU A 264
GLY A 104
ALA A 100
GLY A 130
 None
 1.11A 1igxA-1x0aA:
undetectable		 1igxA-1x0aA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 HIS A  44
GLY A 181
PHE A 184
HIS A 115
TYR A 250
 None
 1.50A 1t69A-1x0aA:
undetectable		 1t69A-1x0aA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A 228
TYR A 224
GLY A 220
 None
 0.64A 2ocuA-1x0aA:
undetectable		 2ocuA-1x0aA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A 302
PRO A 303
LEU A 169
 None
 0.63A 2po5B-1x0aA:
undetectable		 2po5B-1x0aA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 8 LEU A  46
LEU A  33
ALA A  36
HIS A 115
 None
 0.95A 2wekA-1x0aA:
undetectable		 2wekA-1x0aA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 4 TYR A  52
LEU A  49
LEU A  33
HIS A 115
 None
 1.28A 2x7hB-1x0aA:
undetectable		 2x7hB-1x0aA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A 110
THR A 137
LEU A  33
ALA A  28
TYR A 122
 None
 1.49A 3apxA-1x0aA:
undetectable		 3apxA-1x0aA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 215
GLY A 198
SER A 204
ILE A 193
ASP A 207
 None
 1.19A 3cjtG-1x0aA:
undetectable		 3cjtG-1x0aA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 215
GLY A 198
SER A 204
ILE A 193
ASP A 207
 None
 1.19A 3cjtK-1x0aA:
0.0		 3cjtK-1x0aA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 GLY A  45
PRO A 322
LEU A 185
 None
 0.61A 3hcpB-1x0aA:
undetectable		 3hcpB-1x0aA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 8 GLY A  40
GLY A  45
TYR A  52
LEU A  33
 None
 0.80A 4fgzA-1x0aA:
undetectable		 4fgzA-1x0aA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 8 GLY A  40
GLY A  45
TYR A  52
LEU A  33
 None
 0.79A 4fgzB-1x0aA:
undetectable		 4fgzB-1x0aA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 GLN A 257
LEU A  60
PHE A  84
GLY A  85
ALA A  89
 None
 1.25A 4retA-1x0aA:
undetectable		 4retA-1x0aA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 GLU A  81
ALA A  92
ALA A  89
LEU A 263
GLY A 109
 None
 1.30A 5igpA-1x0aA:
undetectable		 5igpA-1x0aA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 THR A 137
PRO A 157
ASP A 172
 None
None
NA  A 403 (-4.6A)
 0.94A 5l8dB-1x0aA:
undetectable		 5l8dB-1x0aA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 THR A 137
PRO A 157
ASP A 172
 None
None
NA  A 403 (-4.6A)
 0.94A 5mwuB-1x0aA:
undetectable		 5mwuB-1x0aA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  38
ALA A  36
VAL A  41
ILE A 168
ALA A 308
 None
 0.90A 5n5dB-1x0aA:
undetectable		 5n5dB-1x0aA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  83
VAL A 259
SER A  64
GLN A 257
VAL A  61
 None
 1.01A 5ubbA-1x0aA:
undetectable		 5ubbA-1x0aA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  15
ALA A  14
LEU A  49
 None
 0.55A 5uunB-1x0aA:
undetectable		 5uunB-1x0aA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 SER A 113
ALA A  92
GLY A 117
SER A  25
THR A 137
 None
 0.99A 5w4zB-1x0aA:
0.0		 5w4zB-1x0aA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 111
PHE A 262
LEU A  77
 None
 0.95A 5x1bC-1x0aA:
undetectable		 5x1bC-1x0aA:
21.26