SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 PHE A  34
GLU A  36
ILE A   5
LEU A  25
 None
 0.95A 1hmyA-1x0lA:
2.2		 1hmyA-1x0lA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 GLU A 215
LEU A 237
ALA A 234
LEU A 233
 None
 0.91A 1hwiD-1x0lA:
undetectable		 1hwiD-1x0lA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 LEU A  25
ILE A 278
VAL A 297
ALA A 281
 None
 0.91A 2j5mA-1x0lA:
undetectable		 2j5mA-1x0lA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 SER A 231
HIS A 260
ASP A 313
 None
 0.78A 2wa2B-1x0lA:
undetectable		 2wa2B-1x0lA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 285
VAL A 327
LEU A 331
VAL A 301
 None
 0.87A 2zujA-1x0lA:
undetectable		 2zujA-1x0lA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 VAL A  24
VAL A 328
THR A 275
THR A  28
 None
 1.28A 3bjwD-1x0lA:
undetectable		 3bjwD-1x0lA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 ALA A 190
ASP A 192
VAL A 196
GLY A 151
ILE A 150
VAL A 198
 None
 1.47A 3el5B-1x0lA:
undetectable		 3el5B-1x0lA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 PHE A 193
VAL A 196
ILE A 168
VAL A 221
 None
 0.70A 3hjoB-1x0lA:
undetectable		 3hjoB-1x0lA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 LEU A 175
GLN A 179
PHE A 182
VAL A 186
 None
 1.14A 3jwqC-1x0lA:
undetectable		 3jwqC-1x0lA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 236
ASP A 232
GLY A 107
ALA A 100
LEU A 243
 None
 1.05A 3ku1H-1x0lA:
undetectable		 3ku1H-1x0lA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ARG A 161
ILE A 157
ILE A  84
ASN A  96
VAL A 117
 None
 1.37A 3ohtA-1x0lA:
undetectable
3ohtB-1x0lA:
undetectable		 3ohtA-1x0lA:
21.43
3ohtB-1x0lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A  14
ARG A 103
GLY A 261
ALA A 276
ALA A 244
 None
 0.91A 3sudA-1x0lA:
undetectable		 3sudA-1x0lA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A  14
ARG A 103
LEU A 241
GLY A 261
ALA A 244
 None
 0.96A 3sufA-1x0lA:
undetectable		 3sufA-1x0lA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ILE A 116
ARG A  98
VAL A 238
GLY A 236
 None
 0.89A 3w1wA-1x0lA:
4.9		 3w1wA-1x0lA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 LEU A 183
ASP A 200
VAL A 196
ILE A 168
 None
 0.89A 3wsjB-1x0lA:
undetectable		 3wsjB-1x0lA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ILE A  18
VAL A  17
ALA A  20
THR A 324
VAL A 301
 None
 1.29A 4oqrA-1x0lA:
undetectable		 4oqrA-1x0lA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 183
GLY A 180
GLU A 119
ALA A 140
 None
 0.86A 4rjdA-1x0lA:
0.6
4rjdB-1x0lA:
undetectable		 4rjdA-1x0lA:
12.26
4rjdB-1x0lA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 6 ILE A 150
ALA A 169
THR A 222
VAL A 186
HIS A 170
 None
 1.42A 5eclD-1x0lA:
undetectable		 5eclD-1x0lA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A  70
GLY A 261
ALA A  83
LEU A  87
GLY A  10
 None
 0.97A 5jglB-1x0lA:
undetectable		 5jglB-1x0lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A 244
THR A  28
LEU A 285
MET A 283
THR A 275
 None
 1.18A 5tl8A-1x0lA:
undetectable		 5tl8A-1x0lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 GLU A 298
ARG A 103
VAL A 115
PRO A  99
 None
 1.04A 6fgdA-1x0lA:
5.8		 6fgdA-1x0lA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ASP A  92
GLY A 227
SER A 231
ALA A 234
ASN A 248
 None
 1.24A 6hu9A-1x0lA:
undetectable
6hu9E-1x0lA:
0.0
6hu9I-1x0lA:
undetectable		 6hu9A-1x0lA:
21.92
6hu9E-1x0lA:
22.62
6hu9I-1x0lA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1x0l HOMOISOCITRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ASP A  92
GLY A 227
SER A 231
ALA A 234
ASN A 248
 None
 1.19A 6hu9L-1x0lA:
undetectable
6hu9P-1x0lA:
undetectable
6hu9T-1x0lA:
undetectable		 6hu9L-1x0lA:
21.92
6hu9P-1x0lA:
22.62
6hu9T-1x0lA:
10.00