SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 270
ALA A 272
PHE A 267
ILE A 125
LEU A 107
 None
 1.22A 1dhfB-1x0mA:
undetectable		 1dhfB-1x0mA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		3 / 3 ALA A 210
VAL A 361
TRP A 350
 None
 1.02A 1gmkA-1x0mA:
undetectable
1gmkB-1x0mA:
undetectable		 1gmkA-1x0mA:
3.01
1gmkB-1x0mA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 100
ALA A  91
TYR A  87
ILE A  79
 None
 1.22A 1oniH-1x0mA:
undetectable
1oniI-1x0mA:
undetectable		 1oniH-1x0mA:
13.68
1oniI-1x0mA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		4 / 5 ALA A 254
TYR A 115
ILE A 117
ASP A 237
 None
 1.26A 1upfA-1x0mA:
2.9		 1upfA-1x0mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		4 / 8 TYR A 201
VAL A 234
GLY A 278
THR A 266
 None
 0.83A 2a1hA-1x0mA:
undetectable
2a1hB-1x0mA:
undetectable		 2a1hA-1x0mA:
22.35
2a1hB-1x0mA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		5 / 11 ILE A  58
GLU A 374
THR A 421
LEU A 373
GLY A 380
 None
 1.33A 2fn1A-1x0mA:
undetectable		 2fn1A-1x0mA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		4 / 6 ILE A 270
TRP A 279
LEU A 103
ILE A 277
 None
 0.91A 2q83B-1x0mA:
undetectable		 2q83B-1x0mA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		5 / 10 ILE A 270
ALA A 272
PHE A 267
ILE A 125
LEU A 107
 None
 1.14A 2w3aB-1x0mA:
undetectable		 2w3aB-1x0mA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 270
GLY A 356
GLY A 240
ARG A 326
 None
 0.79A 2wd9A-1x0mA:
4.2		 2wd9A-1x0mA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 270
GLY A 356
GLY A 240
ARG A 326
 None
 0.78A 2wd9B-1x0mA:
4.7		 2wd9B-1x0mA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		6 / 12 LEU A 141
ILE A 136
LEU A 264
PRO A 204
PRO A 238
PHE A 161
 None
 1.35A 2ygqA-1x0mA:
undetectable		 2ygqA-1x0mA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 270
ALA A 272
PHE A 267
ILE A 125
LEU A 107
 None
 1.12A 3n0hA-1x0mA:
undetectable		 3n0hA-1x0mA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 281
ILE A 117
ILE A 270
ALA A 309
TYR A 312
 None
 1.18A 3ohtA-1x0mA:
undetectable
3ohtB-1x0mA:
undetectable		 3ohtA-1x0mA:
20.55
3ohtB-1x0mA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 270
ALA A 272
PHE A 267
ILE A 125
LEU A 107
 None
 1.14A 3s3vA-1x0mA:
undetectable		 3s3vA-1x0mA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 236
ASN A 208
PHE A 267
 None
 0.81A 5jglB-1x0mA:
undetectable		 5jglB-1x0mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 401
ILE A 422
LEU A 340
ALA A 376
MET A 372
 None
 1.00A 5og9B-1x0mA:
undetectable		 5og9B-1x0mA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		4 / 9 LYS A 410
ILE A 411
ILE A 415
LEU A 418
 None
 0.63A 5vkqB-1x0mA:
undetectable
5vkqC-1x0mA:
undetectable		 5vkqB-1x0mA:
12.87
5vkqC-1x0mA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		3 / 3 ALA A 160
VAL A 234
TYR A 201
 None
 0.62A 5zmqH-1x0mA:
undetectable		 5zmqH-1x0mA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1x0m AMINOTRANSFERASE II
HOMOLOGUE
(Pyrococcus
horikoshii) 		5 / 10 ILE A 359
VAL A 381
ALA A 376
LEU A  61
LEU A 340
 None
 0.96A 6f6nA-1x0mA:
undetectable
6f6nB-1x0mA:
undetectable		 6f6nA-1x0mA:
11.68
6f6nB-1x0mA:
11.56