SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 GLU A 147
HIS A 150
ASP A 175
 SAH  A4261 (-2.7A)
SAH  A4261 (-3.6A)
None
 0.85A 1i9gA-1x1bA:
12.9		 1i9gA-1x1bA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 TYR A 246
GLY A 177
TYR A 310
LEU A 245
TYR A 233
 None
SAH  A4261 (-3.8A)
None
None
None
 1.22A 1pj7A-1x1bA:
3.0		 1pj7A-1x1bA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 GLY A 177
GLY A 178
GLY A 179
LEU A 201
ASP A 227
 SAH  A4261 (-3.8A)
SAH  A4261 ( 4.2A)
SAH  A4261 (-3.3A)
SAH  A4261 (-4.0A)
SAH  A4261 (-2.9A)
 0.43A 1qzzA-1x1bA:
13.1		 1qzzA-1x1bA:
26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		6 / 12 ALA A 157
GLY A 177
ILE A 183
ASP A 227
ILE A 228
TYR A 229
 None
SAH  A4261 (-3.8A)
SAH  A4261 ( 4.8A)
SAH  A4261 (-2.9A)
SAH  A4261 (-3.9A)
SAH  A4261 (-4.8A)
 1.37A 1x1aA-1x1bA:
48.6		 1x1aA-1x1bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		7 / 12 TYR A 135
ALA A 154
GLY A 178
ILE A 183
LEU A 201
ASP A 227
TYR A 229
 None
SAH  A4261 ( 4.0A)
SAH  A4261 ( 4.2A)
SAH  A4261 ( 4.8A)
SAH  A4261 (-4.0A)
SAH  A4261 (-2.9A)
SAH  A4261 (-4.8A)
 1.25A 1x1aA-1x1bA:
48.6		 1x1aA-1x1bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		12 / 12 TYR A 135
GLU A 147
HIS A 150
ALA A 154
GLY A 177
GLY A 179
ILE A 183
LEU A 201
ASP A 227
ILE A 228
TYR A 229
CYH A 242
 None
SAH  A4261 (-2.7A)
SAH  A4261 (-3.6A)
SAH  A4261 ( 4.0A)
SAH  A4261 (-3.8A)
SAH  A4261 (-3.3A)
SAH  A4261 ( 4.8A)
SAH  A4261 (-4.0A)
SAH  A4261 (-2.9A)
SAH  A4261 (-3.9A)
SAH  A4261 (-4.8A)
SAH  A4261 (-3.0A)
 0.28A 1x1aA-1x1bA:
48.6		 1x1aA-1x1bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		6 / 12 TYR A 135
GLU A 147
HIS A 150
GLY A 178
LEU A 201
CYH A 242
 None
SAH  A4261 (-2.7A)
SAH  A4261 (-3.6A)
SAH  A4261 ( 4.2A)
SAH  A4261 (-4.0A)
SAH  A4261 (-3.0A)
 1.11A 1x1aA-1x1bA:
48.6		 1x1aA-1x1bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 GLY A 177
GLY A 178
GLY A 179
LEU A 201
ASP A 227
 SAH  A4261 (-3.8A)
SAH  A4261 ( 4.2A)
SAH  A4261 (-3.3A)
SAH  A4261 (-4.0A)
SAH  A4261 (-2.9A)
 0.46A 1xdsA-1x1bA:
5.4		 1xdsA-1x1bA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 GLY A 177
GLY A 178
GLY A 179
LEU A 201
ASP A 227
 SAH  A4261 (-3.8A)
SAH  A4261 ( 4.2A)
SAH  A4261 (-3.3A)
SAH  A4261 (-4.0A)
SAH  A4261 (-2.9A)
 0.50A 1xdsB-1x1bA:
14.6		 1xdsB-1x1bA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		4 / 4 LEU A 167
SER A 196
LEU A 161
LEU A 271
 None
 1.02A 1yajA-1x1bA:
2.6		 1yajA-1x1bA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 LEU A 167
SER A 196
LEU A 161
LEU A 271
 None
 1.05A 1yajD-1x1bA:
2.7		 1yajD-1x1bA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 GLU A 147
ASN A  98
ILE A 158
GLY A 181
ASN A 211
 SAH  A4261 (-2.7A)
None
None
None
None
 1.27A 2e7fB-1x1bA:
undetectable		 2e7fB-1x1bA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		4 / 5 LEU A 201
ILE A 205
GLY A 178
HIS A 150
 SAH  A4261 (-4.0A)
None
SAH  A4261 ( 4.2A)
SAH  A4261 (-3.6A)
 1.02A 2otfA-1x1bA:
undetectable		 2otfA-1x1bA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 GLY A 177
GLY A 179
GLY A 181
LEU A 201
ILE A 228
 SAH  A4261 (-3.8A)
SAH  A4261 (-3.3A)
None
SAH  A4261 (-4.0A)
SAH  A4261 (-3.9A)
 0.78A 2oxtB-1x1bA:
8.2		 2oxtB-1x1bA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 GLY A 179
HIS A 150
ILE A 158
ASN A  98
 SAH  A4261 (-3.3A)
SAH  A4261 (-3.6A)
None
None
 0.94A 2x0pA-1x1bA:
undetectable		 2x0pA-1x1bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 9 LEU A 160
MET A 187
PHE A 191
GLU A 163
LEU A 271
 None
 1.41A 4la0B-1x1bA:
undetectable		 4la0B-1x1bA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 11 GLY A 177
GLY A 178
LEU A 201
ASP A 227
ILE A 244
 SAH  A4261 (-3.8A)
SAH  A4261 ( 4.2A)
SAH  A4261 (-4.0A)
SAH  A4261 (-2.9A)
None
 0.70A 4pghA-1x1bA:
18.2		 4pghA-1x1bA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 ASP A 175
GLY A 177
LEU A 201
ASP A 227
ILE A 244
 None
SAH  A4261 (-3.8A)
SAH  A4261 (-4.0A)
SAH  A4261 (-2.9A)
None
 0.65A 4pghB-1x1bA:
18.1		 4pghB-1x1bA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 GLY A 177
GLY A 178
LEU A 201
ASP A 227
ILE A 244
 SAH  A4261 (-3.8A)
SAH  A4261 ( 4.2A)
SAH  A4261 (-4.0A)
SAH  A4261 (-2.9A)
None
 0.99A 4pghD-1x1bA:
23.6		 4pghD-1x1bA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 ASP A 114
LEU A 111
PHE A 115
 None
 0.63A 4pthA-1x1bA:
undetectable		 4pthA-1x1bA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		4 / 4 GLY A  78
LEU A  35
PHE A  36
ILE A  73
 None
 0.82A 4xv2A-1x1bA:
undetectable		 4xv2A-1x1bA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		4 / 4 LEU A 199
TYR A 135
PRO A 202
ILE A 205
 None
 1.34A 5esgA-1x1bA:
undetectable		 5esgA-1x1bA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		4 / 7 CYH A 257
ILE A 255
LEU A 245
ALA A 248
 None
 0.85A 5hrqE-1x1bA:
undetectable
5hrqF-1x1bA:
undetectable
5hrqJ-1x1bA:
undetectable		 5hrqE-1x1bA:
5.43
5hrqF-1x1bA:
5.85
5hrqJ-1x1bA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 HIS A 150
SER A 247
HIS A 290
LEU A 302
 SAH  A4261 (-3.6A)
None
None
None
 1.03A 5m8rB-1x1bA:
undetectable		 5m8rB-1x1bA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 HIS A 150
SER A 247
HIS A 290
LEU A 302
 SAH  A4261 (-3.6A)
None
None
None
 1.01A 5m8rD-1x1bA:
undetectable		 5m8rD-1x1bA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 VAL A 208
GLU A 210
LEU A 201
ALA A 204
ARG A 140
 None
None
SAH  A4261 (-4.0A)
None
None
 1.27A 5nd4B-1x1bA:
undetectable		 5nd4B-1x1bA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1x1b CRTF-RELATED PROTEIN
(Chlorobaculum
tepidum) 		5 / 10 LEU A 167
GLY A 169
LEU A 271
VAL A 336
ALA A 238
 None
 1.01A 5o96G-1x1bA:
undetectable
5o96H-1x1bA:
undetectable		 5o96G-1x1bA:
20.11
5o96H-1x1bA:
20.11