SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1x1f SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 1
(Homo
sapiens) 		4 / 7 PHE A 107
GLU A 103
GLN A 126
GLU A 132
 None
 1.11A 2aowA-1x1fA:
undetectable		 2aowA-1x1fA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1x1f SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 1
(Homo
sapiens) 		4 / 6 THR A  70
PHE A  82
LEU A  66
LEU A  84
 None
 1.17A 3bgdA-1x1fA:
undetectable		 3bgdA-1x1fA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1x1f SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A  21
GLU A  40
TRP A 104
 None
 1.29A 3hrdA-1x1fA:
undetectable
3hrdE-1x1fA:
undetectable
3hrdF-1x1fA:
undetectable		 3hrdA-1x1fA:
15.57
3hrdE-1x1fA:
15.57
3hrdF-1x1fA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 1x1f SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 1
(Homo
sapiens) 		4 / 4 PHE A  48
LYS A  60
ILE A  26
THR A  50
 None
 1.35A 3ia4B-1x1fA:
undetectable		 3ia4B-1x1fA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1x1f SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 102
GLY A 101
ARG A 105
TRP A 104
GLU A  40
 None
 1.46A 5fhzD-1x1fA:
undetectable		 5fhzD-1x1fA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1x1f SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 1
(Homo
sapiens) 		4 / 7 TRP A 104
TRP A  38
PHE A  48
GLU A  40
 None
 1.32A 6cifC-1x1fA:
0.0
6cifD-1x1fA:
0.0		 6cifC-1x1fA:
17.45
6cifD-1x1fA:
17.45