SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		4 / 8 GLU A 232
ARG A 235
ARG A 236
LEU A 206
 None
 0.81A 1cmaA-1x1oA:
undetectable
1cmaB-1x1oA:
undetectable		 1cmaA-1x1oA:
18.68
1cmaB-1x1oA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		4 / 8 ALA A 107
ILE A  47
GLY A  57
PRO A  76
 None
 0.59A 1sh9A-1x1oA:
undetectable		 1sh9A-1x1oA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		4 / 7 GLY A  57
PHE A  74
ILE A  47
PHE A  65
 None
 1.01A 2qmzA-1x1oA:
undetectable
2qmzB-1x1oA:
undetectable		 2qmzA-1x1oA:
21.03
2qmzB-1x1oA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		5 / 11 SER A 246
THR A 138
SER A 266
TYR A 124
GLY A 247
 None
 1.22A 2xf3A-1x1oA:
0.0		 2xf3A-1x1oA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		5 / 11 SER A 246
THR A 138
SER A 266
TYR A 124
GLY A 247
 None
 1.22A 2xf3B-1x1oA:
0.0		 2xf3B-1x1oA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		5 / 11 SER A 246
THR A 138
SER A 266
TYR A 124
GLY A 247
 None
 1.24A 2xh9A-1x1oA:
undetectable		 2xh9A-1x1oA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		5 / 10 SER A 246
THR A 138
SER A 266
TYR A 124
GLY A 247
 None
 1.22A 2xh9B-1x1oA:
0.0		 2xh9B-1x1oA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		3 / 3 LYS A 190
LYS A 198
VAL A 199
 None
 1.04A 3brfA-1x1oA:
undetectable		 3brfA-1x1oA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		5 / 12 LEU A  22
GLY A  99
LEU A 101
PHE A  65
ALA A 107
 None
 1.00A 3tbgB-1x1oA:
0.0		 3tbgB-1x1oA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		5 / 12 LEU A  22
GLY A  99
LEU A 101
PHE A  65
ALA A 107
 None
 1.02A 3tbgD-1x1oA:
0.0		 3tbgD-1x1oA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		5 / 9 ALA A 127
ILE A 135
VAL A 267
ALA A 257
ALA A 258
 None
 1.02A 4lbgB-1x1oA:
undetectable		 4lbgB-1x1oA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		5 / 11 LEU A  22
GLY A  99
LEU A 101
PHE A  65
ALA A 107
 None
 1.09A 4wnuC-1x1oA:
undetectable		 4wnuC-1x1oA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		5 / 8 VAL A  93
PHE A  65
GLY A 103
ALA A 102
GLY A  99
 None
 1.21A 4zjzB-1x1oA:
2.1		 4zjzB-1x1oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		4 / 6 ALA A  68
ARG A  94
GLY A  43
GLU A  44
 None
 0.95A 5btgA-1x1oA:
undetectable
5btgB-1x1oA:
undetectable
5btgC-1x1oA:
undetectable		 5btgA-1x1oA:
23.57
5btgB-1x1oA:
26.27
5btgC-1x1oA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		5 / 9 THR A 121
VAL A 267
GLY A 268
THR A 271
VAL A 153
 None
 1.41A 5cp4A-1x1oA:
undetectable		 5cp4A-1x1oA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		4 / 6 VAL A 262
ALA A 133
VAL A 265
TYR A 264
 None
 1.02A 5i8fA-1x1oA:
undetectable		 5i8fA-1x1oA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 1x1o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Thermus
thermophilus) 		5 / 12 VAL A  90
LEU A  55
GLU A  89
LEU A 111
LEU A  58
 None
 1.18A 6f6iA-1x1oA:
undetectable
6f6iB-1x1oA:
0.0		 6f6iA-1x1oA:
14.62
6f6iB-1x1oA:
12.94