SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1x1s RAS-RELATED PROTEIN
M-RAS
(Mus
musculus) 		3 / 3 PHE A  38
LEU A  29
SER A 156
 GNP  A 179 (-4.2A)
None
GNP  A 179 (-3.6A)
 0.72A 1e7aA-1x1sA:
1.0		 1e7aA-1x1sA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1x1s RAS-RELATED PROTEIN
M-RAS
(Mus
musculus) 		3 / 3 THR A 167
LEU A 171
VAL A 174
 None
 0.36A 1mz9E-1x1sA:
undetectable		 1mz9E-1x1sA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 1x1s RAS-RELATED PROTEIN
M-RAS
(Mus
musculus) 		5 / 12 ILE A 150
TYR A  92
VAL A  94
LEU A 123
LEU A  29
 None
 0.92A 2rctA-1x1sA:
undetectable		 2rctA-1x1sA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1x1s RAS-RELATED PROTEIN
M-RAS
(Mus
musculus) 		4 / 8 ASN A 163
LEU A 162
TYR A 152
ARG A 138
 None
 1.14A 4ijiF-1x1sA:
undetectable		 4ijiF-1x1sA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1x1s RAS-RELATED PROTEIN
M-RAS
(Mus
musculus) 		5 / 12 ILE A 150
TYR A  92
VAL A  94
LEU A 123
LEU A  29
 None
 0.91A 4qynA-1x1sA:
undetectable		 4qynA-1x1sA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1x1s RAS-RELATED PROTEIN
M-RAS
(Mus
musculus) 		3 / 3 LEU A  16
VAL A 164
ASP A 165
 None
 0.71A 4y8wC-1x1sA:
undetectable		 4y8wC-1x1sA:
16.99