SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  60
LEU A  54
GLY A  30
VAL A 120
ALA A  74
 None
 1.07A 1axwA-1x25A:
undetectable		 1axwA-1x25A:
16.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A  16
ILE A  32
PRO A 111
GLU A 117
 None
 0.47A 1oniA-1x25A:
24.1
1oniB-1x25A:
24.1		 1oniA-1x25A:
43.61
1oniB-1x25A:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		4 / 6 TYR A  16
ILE A  32
PRO A 111
GLU A 117
 None
 0.43A 1oniB-1x25A:
24.1
1oniC-1x25A:
24.1		 1oniB-1x25A:
43.61
1oniC-1x25A:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		4 / 6 TYR A  16
ILE A  32
PRO A 111
GLU A 117
 None
 0.28A 1oniA-1x25A:
24.1
1oniC-1x25A:
24.1		 1oniA-1x25A:
43.61
1oniC-1x25A:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A  16
ILE A  32
PRO A 111
GLU A 117
 None
 0.38A 1oniD-1x25A:
24.2
1oniE-1x25A:
24.3		 1oniD-1x25A:
43.61
1oniE-1x25A:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A  16
ILE A  32
PRO A 111
GLU A 117
 None
 0.49A 1oniG-1x25A:
24.0
1oniI-1x25A:
24.0		 1oniG-1x25A:
43.61
1oniI-1x25A:
43.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  60
LEU A  54
GLY A  30
VAL A 120
ALA A  74
 None
 1.02A 1tlsA-1x25A:
0.1		 1tlsA-1x25A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  60
LEU A  54
GLY A  30
VAL A 120
ALA A  74
 None
 1.08A 1tsnA-1x25A:
undetectable		 1tsnA-1x25A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 12 SER A  67
ARG A 102
PRO A 100
VAL A  71
ILE A  57
 None
 1.37A 2fj1A-1x25A:
undetectable		 2fj1A-1x25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 12 SER A  67
ARG A 102
PRO A 100
VAL A  71
ILE A  57
 None
 1.27A 2o7oA-1x25A:
undetectable		 2o7oA-1x25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 12 SER A  67
ARG A 102
PRO A 100
VAL A  71
ILE A  57
 None
 1.46A 2tctA-1x25A:
undetectable		 2tctA-1x25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 11 SER A  67
ARG A 102
PRO A 100
VAL A  71
ILE A  57
 None
 1.36A 2trtA-1x25A:
undetectable		 2trtA-1x25A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VKE_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 11 SER A  67
ARG A 102
PRO A 100
VAL A  71
ILE A  57
 None
 1.32A 2vkeA-1x25A:
undetectable		 2vkeA-1x25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 12 SER A  67
ARG A 102
PRO A 100
VAL A  71
ILE A  57
 None
 1.32A 2xpvA-1x25A:
undetectable		 2xpvA-1x25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 12 SER A  67
ARG A 102
PRO A 100
VAL A  71
ILE A  57
 None
 1.35A 2xpwA-1x25A:
undetectable		 2xpwA-1x25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 8 LEU A  54
VAL A  28
ILE A  60
VAL A  61
LEU A  68
 None
 1.38A 3kp6A-1x25A:
undetectable
3kp6B-1x25A:
undetectable		 3kp6A-1x25A:
22.42
3kp6B-1x25A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A  54
VAL A 120
VAL A  76
LEU A  68
 None
 1.03A 3v81C-1x25A:
undetectable		 3v81C-1x25A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 12 SER A  67
ARG A 102
PRO A 100
VAL A  71
ILE A  57
 None
 1.40A 4b3aA-1x25A:
undetectable		 4b3aA-1x25A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		3 / 3 ASP A  35
ARG A  37
ASP A  55
 None
 0.74A 4fp9A-1x25A:
undetectable		 4fp9A-1x25A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A  54
VAL A 120
VAL A  76
LEU A  68
 None
 1.04A 4puoC-1x25A:
undetectable		 4puoC-1x25A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A  54
VAL A 120
VAL A  76
LEU A  68
 None
 1.17A 4q0bA-1x25A:
undetectable		 4q0bA-1x25A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		5 / 12 SER A  67
ARG A 102
PRO A 100
VAL A  71
ILE A  57
 None
 1.41A 4v2gB-1x25A:
undetectable		 4v2gB-1x25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A  57
VAL A  22
LYS A  -1
SER A 123
 None
 1.08A 6fbvC-1x25A:
undetectable		 6fbvC-1x25A:
8.33