SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1x2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 12 LEU A 135
ILE A  43
ALA A 119
ALA A 123
PRO A 127
 None
 0.98A 1cbsA-1x2bA:
undetectable		 1cbsA-1x2bA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		3 / 3 TRP A 200
VAL A 202
TRP A 203
 None
 1.31A 1gmkC-1x2bA:
undetectable
1gmkD-1x2bA:
undetectable		 1gmkC-1x2bA:
5.47
1gmkD-1x2bA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 9 ALA A  13
LEU A  31
TRP A  29
GLY A  17
TYR A  28
 None
 1.31A 1ncwH-1x2bA:
0.0
1ncwL-1x2bA:
undetectable		 1ncwH-1x2bA:
19.75
1ncwL-1x2bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 10 ALA A  13
LEU A  31
TRP A  29
GLY A  17
TYR A  28
 None
 1.39A 1ruaH-1x2bA:
0.0
1ruaL-1x2bA:
0.0		 1ruaH-1x2bA:
19.75
1ruaL-1x2bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 9 ALA A  13
LEU A  31
TRP A  29
GLY A  17
TYR A  28
 None
 1.39A 1rulH-1x2bA:
undetectable
1rulL-1x2bA:
undetectable		 1rulH-1x2bA:
19.75
1rulL-1x2bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 9 ALA A  13
LEU A  31
TRP A  29
GLY A  17
TYR A  28
 None
 1.30A 1rumH-1x2bA:
0.0
1rumL-1x2bA:
undetectable		 1rumH-1x2bA:
19.75
1rumL-1x2bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 9 ALA A  13
LEU A  31
TRP A  29
GLY A  17
TYR A  28
 None
 1.32A 1rupH-1x2bA:
0.0
1rupL-1x2bA:
undetectable		 1rupH-1x2bA:
19.75
1rupL-1x2bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 11 GLY A  45
GLY A  46
SER A 113
PHE A 228
HIS A 296
 STX  A 401 (-3.6A)
STX  A 401 (-3.6A)
STX  A 401 (-2.8A)
None
STX  A 401 (-4.5A)
 1.12A 1w76A-1x2bA:
12.3		 1w76A-1x2bA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 12 LEU A 288
ILE A 290
HIS A 296
GLY A 265
GLY A 112
 None
None
STX  A 401 (-4.5A)
None
STX  A 401 (-4.8A)
 1.14A 1zz1C-1x2bA:
undetectable		 1zz1C-1x2bA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 8 PHE A 228
PHE A 219
TYR A 149
TYR A 150
 None
 1.03A 2aoxA-1x2bA:
2.7		 2aoxA-1x2bA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 12 LEU A 135
ILE A  43
ALA A 119
ALA A 123
PRO A 127
 None
 0.96A 2fr3A-1x2bA:
undetectable		 2fr3A-1x2bA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 12 GLY A 295
GLY A 265
ASP A 268
ALA A 270
THR A 207
 None
None
None
STX  A 401 ( 4.7A)
None
 1.07A 2gluA-1x2bA:
2.4		 2gluA-1x2bA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 6 ASN A  86
HIS A 234
ILE A  43
GLN A  71
 None
 1.25A 2hkkA-1x2bA:
undetectable		 2hkkA-1x2bA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 6 HIS A  44
TYR A 235
ARG A  72
GLY A  73
 None
 1.28A 2i30A-1x2bA:
0.0		 2i30A-1x2bA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 6 GLY A 115
HIS A 296
HIS A 264
CYH A 271
 None
STX  A 401 (-4.5A)
None
STX  A 401 ( 4.9A)
 1.43A 3ai8B-1x2bA:
undetectable		 3ai8B-1x2bA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 10 GLY A  33
TRP A 107
GLN A 106
ASN A  34
GLY A  37
 None
 1.31A 3km6A-1x2bA:
undetectable		 3km6A-1x2bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 9 GLY A  33
TRP A 107
GLN A 106
ASN A  34
GLY A  37
 None
 1.38A 3kmoA-1x2bA:
undetectable		 3kmoA-1x2bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 7 PHE A 224
GLY A 220
GLY A 205
CYH A  74
 None
 0.97A 3ko0M-1x2bA:
undetectable
3ko0P-1x2bA:
undetectable		 3ko0M-1x2bA:
15.41
3ko0P-1x2bA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 7 GLU A  62
TYR A  64
GLY A 316
ARG A  63
 None
 0.96A 4fgzA-1x2bA:
2.2		 4fgzA-1x2bA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 12 CYH A 271
ASN A 275
LEU A 249
GLY A 137
GLY A 111
 STX  A 401 ( 4.9A)
None
None
None
None
 1.20A 4n09A-1x2bA:
undetectable		 4n09A-1x2bA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 7 THR A  88
LEU A  91
THR A 117
LEU A 118
 None
 0.93A 4z90A-1x2bA:
undetectable
4z90B-1x2bA:
undetectable
4z90C-1x2bA:
undetectable
4z90D-1x2bA:
undetectable
4z90E-1x2bA:
undetectable		 4z90A-1x2bA:
22.16
4z90B-1x2bA:
22.16
4z90C-1x2bA:
22.16
4z90D-1x2bA:
22.16
4z90E-1x2bA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		3 / 3 ARG A  56
TYR A  28
GLU A  30
 None
 0.69A 4zzbE-1x2bA:
undetectable		 4zzbE-1x2bA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 7 HIS A 296
CYH A 271
GLY A 295
HIS A 264
 STX  A 401 (-4.5A)
STX  A 401 ( 4.9A)
None
None
 1.38A 5a5zC-1x2bA:
undetectable		 5a5zC-1x2bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 12 GLY A 240
THR A  88
ASN A 275
LEU A 141
CYH A 271
 None
None
None
None
STX  A 401 ( 4.9A)
 1.44A 5fhzA-1x2bA:
undetectable		 5fhzA-1x2bA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 5 GLY A  46
SER A 113
ARG A 136
GLY A 112
 STX  A 401 (-3.6A)
STX  A 401 (-2.8A)
STX  A 401 (-2.8A)
STX  A 401 (-4.8A)
 1.05A 5kprA-1x2bA:
undetectable		 5kprA-1x2bA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 12 VAL A 130
GLU A 128
LEU A 279
LEU A 120
ALA A 123
 None
 1.08A 5nd7B-1x2bA:
3.3		 5nd7B-1x2bA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 5 LEU A 242
PHE A 241
LEU A 141
PHE A 139
 None
None
None
STX  A 401 ( 4.7A)
 1.24A 5xdxP-1x2bA:
undetectable
5xdxW-1x2bA:
undetectable		 5xdxP-1x2bA:
20.40
5xdxW-1x2bA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 11 ALA A  13
ASP A  70
VAL A 109
ILE A  43
ILE A  95
 None
 1.05A 5y80A-1x2bA:
0.0		 5y80A-1x2bA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		5 / 7 GLY A 112
GLY A  46
PRO A  47
GLY A  48
GLY A  49
 STX  A 401 (-4.8A)
STX  A 401 (-3.6A)
None
None
None
 0.86A 6ag0A-1x2bA:
undetectable		 6ag0A-1x2bA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		4 / 8 THR A 207
VAL A 208
GLU A 204
SER A 201
 None
None
STX  A 401 (-3.1A)
None
 1.09A 6fbvC-1x2bA:
undetectable		 6fbvC-1x2bA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 1x2b PROLINE
IMINOPEPTIDASE
(Serratia
marcescens) 		3 / 3 ARG A 156
PHE A 157
GLY A 153
 None
 0.78A 6fgdA-1x2bA:
2.7		 6fgdA-1x2bA:
19.53